Turner, Raymond W. - University of Calgary - Department of Cell Biology and Anatomy

个人简介

Dr. Turner received his PhD in Neurophysiology at the University of British Columbia in 1985, and completed to Postdoctoral training periods at the National Institutes of Health in Bethesda, MD, and the Department of Anatomy at the University of Ottawa. He joined the University Calgary in 1991 and is now a Professor in the Department of Cell Biology and Anatomy and a secondary member of the Department of Physiology and Pharmacology. He also serves in the capacity of Associate Dean Research Grants in the Cumming School of Medicine. Work in Dr. Turner’s lab centers on the nature of interactions between ion channels at the molecular and physiological levels, with an emphasis on channels activated primarily in the subthreshold region. Recent work has focused on the relationship between a low voltage-activated T type calcium channel and Kv4, HCN, BK, and IKCa channels, and their role in controlling the response to synaptic input or the pattern of spike output in cerebellar or hippocampal neurons using a combination of electrophysiology, immunocytochemistry, molecular biology, and optogenetics. With the recognition that IKCa channels are expressed in the CNS, the functional role of this channel type is also being investigated in other central neurons.

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Long-Term Potentiation at the Mossy Fiber-Granule Cell Relay Invokes Postsynaptic Second-Messenger Regulation of Kv4 Channels.Rizwan AP, Zhan X, Zamponi GW, Turner RW.J Neurosci. 2016 Nov 2;36(44):11196-11207. Assessing the role of IKCa channels in generating the sAHP of CA1 hippocampal pyramidal cells.Turner RW, Asmara H, Engbers JD, Miclat J, Rizwan AP, Sahu G, Zamponi GW.Channels (Austin). 2016 Jul 3;10(4):313-9. doi: 10.1080/19336950.2016.1161988. Determinants of rebound burst responses in rat cerebellar nuclear neurons to physiological stimuli.Dykstra S, Engbers JD, Bartoletti TM, Turner RW.J Physiol. 2016 Feb 15;594(4):985-1003. doi: 10.1113/JP271894. The expression pattern of a Cav3-Kv4 complex differentially regulates spike output in cerebellar granule cells.Heath NC, Rizwan AP, Engbers JD, Anderson D, Zamponi GW, Turner RW.J Neurosci. 2014 Jun 25;34(26):8800-12. doi: 10.1523/JNEUROSCI.0981-14.2014. Neuronal expression of the intermediate conductance calcium-activated potassium channel KCa3.1 in the mammalian central nervous system.Turner RW, Kruskic M, Teves M, Scheidl-Yee T, Hameed S, Zamponi GW.Pflugers Arch. 2015 Feb;467(2):311-28. doi: 10.1007/s00424-014-1523-1. T-type channels buddy up.Turner RW, Zamponi GW.Pflugers Arch. 2014 Apr;466(4):661-75. doi: 10.1007/s00424-013-1434-6. Review. Signal processing by T-type calcium channel interactions in the cerebellum.Engbers JD, Anderson D, Zamponi GW, Turner RW.Front Cell Neurosci. 2013 Nov 27;7:230. doi: 10.3389/fncel.2013.00230. Review. Modeling interactions between voltage-gated Ca (2+) channels and KCa1.1 channels.Engbers JD, Zamponi GW, Turner RW.Channels (Austin). 2013 Nov-Dec;7(6):524-9. doi: 10.4161/chan.25867. The Cav3-Kv4 complex acts as a calcium sensor to maintain inhibitory charge transfer during extracellular calcium fluctuations.Anderson D, Engbers JD, Heath NC, Bartoletti TM, Mehaffey WH, Zamponi GW, Turner RW.J Neurosci. 2013 May 1;33(18):7811-24. doi: 10.1523/JNEUROSCI.5384-12.2013. Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes.Rehak R, Bartoletti TM, Engbers JD, Berecki G, Turner RW, Zamponi GW.PLoS One. 2013 Apr 23;8(4):e61844. doi: 10.1371/journal.pone.0061844. Bistability in Purkinje neurons: ups and downs in cerebellar research.Engbers JD, Fernandez FR, Turner RW.Neural Netw. 2013 Nov;47:18-31. doi: 10.1016/j.neunet.2012.09.006. Review. Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells.Engbers JD, Anderson D, Asmara H, Rehak R, Mehaffey WH, Hameed S, McKay BE, Kruskic M, Zamponi GW, Turner RW.Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2601-6. doi: 10.1073/pnas.1115024109. Distinct roles for I(T) and I(H) in controlling the frequency and timing of rebound spike responses.Engbers JD, Anderson D, Tadayonnejad R, Mehaffey WH, Molineux ML, Turner RW.J Physiol. 2011 Nov 15;589(Pt 22):5391-413. doi: 10.1113/jphysiol.2011.215632. Erratum in: J Physiol. 2013 Jul 1;591(Pt 13):3451. Signaling complexes of voltage-gated calcium channels.Turner RW, Anderson D, Zamponi GW.Channels (Austin). 2011 Sep-Oct;5(5):440-8. doi: 10.4161/chan.5.5.16473. Review. Regulation of the KV4.2 complex by CaV3.1 calcium channels.Anderson D, Rehak R, Hameed S, Mehaffey WH, Zamponi GW, Turner RW.Channels (Austin). 2010 May-Jun;4(3):163-7. Rebound discharge in deep cerebellar nuclear neurons in vitro.Tadayonnejad R, Anderson D, Molineux ML, Mehaffey WH, Jayasuriya K, Turner RW.Cerebellum. 2010 Sep;9(3):352-74. doi: 10.1007/s12311-010-0168-7. Review. Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes.Anderson D, Mehaffey WH, Iftinca M, Rehak R, Engbers JD, Hameed S, Zamponi GW, Turner RW.Nat Neurosci. 2010 Mar;13(3):333-7. doi: 10.1038/nn.2493. Reliability of triggering postinhibitory rebound bursts in deep cerebellar neurons.Tadayonnejad R, Mehaffey WH, Anderson D, Turner RW.Channels (Austin). 2009 May-Jun;3(3):149-55. Regulation of somatic firing dynamics by backpropagating dendritic spikes.Mehaffey WH, Fernandez FR, Doiron B, Turner RW.J Physiol Paris. 2008 Jul-Nov;102(4-6):181-94. doi: 10.1016/j.jphysparis.2008.10.011. Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons.Molineux ML, Mehaffey WH, Tadayonnejad R, Anderson D, Tennent AF, Turner RW.J Neurophysiol. 2008 Nov;100(5):2684-701. doi: 10.1152/jn.90427.2008.