Hawkes, Richard - University of Calgary - Department of Cell Biology and Anatomy

个人简介

Dr. Hawkes graduated from University College London and completed a Ph.D at the University of Hull. After postdoctoral fellowships at the Hebrew University of Jerusalem, the Institute of Molecular Biology of the University of Oregon and the Friedrich Miescher Institute in Switzerland, he was recruited to Université Laval, funded by the Medical Research Council of Canada, where he set up a research lab to apply then new molecular biology techniques to the development of the cerebellum. Six years later he accepted the role of Head of Cell Biology & Anatomy at the University of Calgary. After ten years as Department Head he spent four years as Associate Dean, Faculty of Graduate Studies, followed by ten years as Senior Associate Dean Research in Medicine, for four of which he also served as Associate Vice President Research for the University.

研究领域

Dr. Hawkes’s research concerns the structure and development of the mammalian cerebellum. His discovery of key patterning markers in the cerebellum – “zebrins” - is the foundation of the modern "zones-and-stripes" model of cerebellar organization. These studies of adult cerebellar architecture are the basis for understanding pattern formation during cerebellar development, which included the first identification of the canonical Reelin-Disabled signaling pathway. His collaborative studies of cerebellar development have extended to models of human disease including neuronal death in the childhood disorder Niemann-Pick, dysbindin-dystrobrevin interactions in nervous system correlates of muscular dystrophy, and the identification of a mutation in the α1A-voltage-sensitive calcium channel gene that defined both novel in vivo roles for the gene in neuronal function and survival, and identified it as a key mammalian epilepsy locus. Finally, he invented and patented the dot immunobinding assay, an immunological technique that is used in labs worldwide and has become a “citation classic”.

近期论文

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Consensus Paper: Cerebellar Development.Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerková G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawkes R.Cerebellum. 2016 Dec;15(6):789-828. Review. Maternal immune activation produces cerebellar hyperplasia and alterations in motor and social behaviors in male and female mice.Aavani T, Rana SA, Hawkes R, Pittman QJ.Cerebellum. 2015 Oct;14(5):491-505. doi: 10.1007/s12311-015-0669-5. Zebrin II / aldolase C expression in the cerebellum of the western diamondback rattlesnake (Crotalus atrox).Aspden JW, Armstrong CL, Gutierrez-Ibanez CI, Hawkes R, Iwaniuk AN, Kohl T, Graham DJ, Wylie DR.PLoS One. 2015 Feb 18;10(2):e0117539. doi: 10.1371/journal.pone.0117539. Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse.Hawkes R.Front Syst Neurosci. 2014 Mar 28;8:41. doi: 10.3389/fnsys.2014.00041. Review. Antigenic compartmentation of the cerebellar cortex in an Australian marsupial, the tammar wallaby Macropus eugenii.Marzban H, Hoy N, Marotte LR, Hawkes R.Brain Behav Evol. 2012;80(3):196-209. doi: 10.1159/000340069. Pattern formation during development of the embryonic cerebellum.Dastjerdi FV, Consalez GG, Hawkes R.Front Neuroanat. 2012 Apr 4;6:10. doi: 10.3389/fnana.2012.00010. Patterned Purkinje cell loss in the ataxic sticky mouse.Sarna JR, Hawkes R.Eur J Neurosci. 2011 Jul;34(1):79-86. doi: 10.1111/j.1460-9568.2011.07725.x. Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum.Chung SH, Marzban H, Aldinger K, Dixit R, Millen K, Schuurmans C, Hawkes R.Neural Dev. 2011 May 18;6:25. doi: 10.1186/1749-8104-6-25. Compartmentation of the cerebellar cortex in the naked mole-rat (Heterocephalus glaber).Marzban H, Hoy N, Aavani T, Sarko DK, Catania KC, Hawkes R.Cerebellum. 2011 Sep;10(3):435-48. doi: 10.1007/s12311-011-0251-8. On the architecture of the posterior zone of the cerebellum.Marzban H, Hawkes R.Cerebellum. 2011 Sep;10(3):422-34. doi: 10.1007/s12311-010-0208-3. Antigenic compartmentation of the cerebellar cortex in the chicken (Gallus domesticus).Marzban H, Chung SH, Pezhouh MK, Feirabend H, Watanabe M, Voogd J, Hawkes R.J Comp Neurol. 2010 Jun 15;518(12):2221-39. doi: 10.1002/cne.22328. Purkinje cell phenotype restricts the distribution of unipolar brush cells.Chung SH, Sillitoe RV, Croci L, Badaloni A, Consalez G, Hawkes R.Neuroscience. 2009 Dec 29;164(4):1496-508. doi: 10.1016/j.neuroscience.2009.09.080. Purkinje cell compartmentation of the cerebellum of microchiropteran bats.Kim JY, Marzban H, Chung SH, Watanabe M, Eisenman LM, Hawkes R.J Comp Neurol. 2009 Nov 10;517(2):193-209. doi: 10.1002/cne.22147. Compartmentation of the cerebellar nuclei of the mouse.Chung SH, Marzban H, Hawkes R.Neuroscience. 2009 Jun 16;161(1):123-38. doi: 10.1016/j.neuroscience.2009.03.037. Phospholipase Cbeta4 expression identifies a novel subset of unipolar brush cells in the adult mouse cerebellum.Chung SH, Marzban H, Watanabe M, Hawkes R.Cerebellum. 2009 Sep;8(3):267-76. doi: 10.1007/s12311-009-0092-x. Spatial distribution of corticotropin-releasing factor immunopositive climbing fibers in the mouse cerebellum: analysis by whole mount immunohistochemistry.Sawada K, Fukui Y, Hawkes R.Brain Res. 2008 Jul 30;1222:106-17. doi: 10.1016/j.brainres.2008.05.029. A novel transverse expression domain in the mouse cerebellum revealed by a neurofilament-associated antigen.Marzban H, Kim CT, Doorn D, Chung SH, Hawkes R.Neuroscience. 2008 Jun 2;153(4):1190-201. doi: 10.1016/j.neuroscience.2008.02.036. Compartmentation of GABA B receptor2 expression in the mouse cerebellar cortex.Chung SH, Kim CT, Hawkes R.Cerebellum. 2008;7(3):295-303. doi: 10.1007/s12311-008-0030-3. Purkinje cell subtype specification in the cerebellar cortex: early B-cell factor 2 acts to repress the zebrin II-positive Purkinje cell phenotype.Chung SH, Marzban H, Croci L, Consalez GG, Hawkes R.Neuroscience. 2008 May 15;153(3):721-32. doi: 10.1016/j.neuroscience.2008.01.090. Golgi cell dendrites are restricted by Purkinje cell stripe boundaries in the adult mouse cerebellar cortex.Sillitoe RV, Chung SH, Fritschy JM, Hoy M, Hawkes R.J Neurosci. 2008 Mar 12;28(11):2820-6. doi: 10.1523/JNEUROSCI.4145-07.2008.