SHARMA, NAVNEET - University of Calgary - Department of Biochemistry & Molecular Biology

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Proteases are known to play a critical role in different physiological and pathological processes. There are different types of proteinases based on their characteristics mainly general specificity of substrates. Some of the proteases are well defined with respect to their substrates and specificities but many of them are still poorly characterized. Different proteomic approaches have been developed to address these issues complimented by Structural genomics approaches. We are interested in the ‘Characterization of the specificity and identification of putative substrates of these proteases by employing bacteriophage display of small peptides.' Presently we are working on determining the substrate specificities of Implantation Serine Proteinases (ISP1 and ISP2), novel serine proteinases characterized from the uterine endometrium and early stage embryos by Derrick Rancourt lab) and Human Kallikreins in collaboration with Prof. Eleftherios Diamandis, Mount Sinai Hospital, Toronto. We are looking forward to work with many more poorly characterized proteinases. Any queries for collaborating in this regard are welcome.

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Sharma, N. and Rancourt D.E. 'Strypsin 1’ in Handbook of Proteolytic Enzymes (3rd edition) an Elsevier publication, Chapter 605 edited by Barrett et al. to be published in 2012 Sharma, N. & Rancourt, D.E. ‘Implantation Serine Proteinases-Structure, Function and Evolution’ in Serine Proteases: Mechanism, Structure and Evolution by Isamu Chiba & Takao Kamio to be published in 2012 by Nova Publishers, Hauppauge, New York (USA) Thomas, B., Nishikawa, S., Ito, K., Chopra, P., Sharma, N., Evans, D.H., Tyrell, B.L., Bathe, O.F. and Rancourt, D.E. ‘Peptide vaccination is superior to genetic vaccination using a recombineered bacteriophage Lambda subunit vaccine’ Vaccine (2012) 30 (6) 998-1008 Sharma, N., Kumar, R., Renaux, B., Saifeddin, M., Nishikawa, S., Ramachandran, R., Hollenberg, MD and Rancourt, D. ‘Implantation Serine Proteinase 1 shows mixed substrate specificity and can silence the signalling through Proteinase Activated Receptors’ PLOS One (2011) 6 (11) e27888 Sharma, N., Oikonomopoulou, K., Ito, K., Renaux, B., Diamandis, E. and Hollenberg, M. Rancourt, D., ‘Substrate specificity determination of Implantation Serine Proteinase complex and Human Kallikrein 6 (KLK6) by the phage display' Biological Chemistry (2008) 389 (8) Sharma, N., Kaur, J., Xu, H., Zur Nieden, N. & Rancourt, D. ‘Characterization of Secretory Leukocyte Proteinase Inhibitor (SLPI) as an inhibitor of Implantation Serine Proteinase' Molecular Reproduction and Development (2008) 75 (7) 1136-1142 Sharma, N., Liu, S., Tang, L., Irwin, J., Meng, G. & Rancourt, D. ‘Implantation serine proteinases heterodimerize and are critical in hatching and implantation' BMC Developmental Biology (2006) 6(1), 61 Sharma N. and Qazi G. N. ‘Inhibition of glucose oxidation in Erwinia herbicola by a high concentration of dissolved Oxygen' World J. Microbiology & Biotechnology (1994) 10, 313-319 Qazi, G.N., Sharma, N. & Parshad, R. ‘Role of dissolved oxygen as a regulator for the direct oxidation of glucose by Erwinia herbicola & Gluconobacter oxydans' Journal of Fermentation & Bioengineering (1993) 76(4), 336-339 Sharma, N., Parshad, R. & Qazi, G.N. ‘Electron transport system associated with direct glucose oxidation in Gluconobacter oxydans' Biotechnology Letters (1992) 14(5), 391-396 Buse, R., Onken, U., Qazi, G.N., Sharma, N., Parshad, R. & Verma, V. ‘Influence of dilution rate & dissolved oxygen concentration on the keto-acid production by Gluconobacter oxydans subsp. Melanogenus' Enzyme Microbial Technology (1992), 14(12), 1001-1006 Sharma, N., Kumar, R., Renaux, B., Saifeddin, M., Nishikawa, S., Ramachandran, R., Hollenberg, MD. and Rancourt, D. ‘Implantation Serine Proteinase 1 shows mixed substrate specificity and can silence the signalling through Proteinase Activated Receptors' in preparation

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