个人简介

B.Sc. (Bachelor of Science) M.D. (Doctor of Medicine) M.Sc. (Master of Science)

研究领域

Molecular Biology and Disease

The primary interest of our laboratory is to define the mechanisms of hormone action. To this end we have examined the hormonal regulation of apolipoprotein AI. This protein mediates reverse cholesterol transport, a normal physiologic process that guards against heart disease. In the past year we have discovered that signal transduction pathways induces apo AI gene activity. Both PKA and PKC causes marked 4- to 5-fold induction of apo AI promoter activity. Our studies have now lead us to develop gene and cell therapy to raise the levels of apo AI protein. This finding will help us develop new ways to increase gene activity.

近期论文

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Xiao, H., Zhuang, W., Wang, S., Yu, B., Chen, G., Zhou, M. , Wong, N.C.W. Arterial embolization: a novel approach to thyroid ablative therapy for Graves' Disease. Journal of Clinical Endocrinology and Metabolism. 2002 Aug;87(8):3583-9. Sayo, Y. , Murao, K. , Imachi, H. , Cao, W.M., Sato, M. , Dobashi, H., Wong, N. C.W., Ishida, T. The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells. Endocrinology. 2002 Jun;143(6):2437-40. Kojima, H., Nakamura, T., Fujita, Y., Kishi , A., Fujimiya, M., Yamada, S., Kudo, M., Nishio, Y., Maegawa, H., Haneda, M., Yasuda, H., Kojima, I., Seno, M. , Wong, N.C.W., Kikkawa, R., Kashiwagi, A. Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes. 2002 May;51(5):1398-408. Zaiss, A.-K., Liu, Q., Bowen, G.P., Wong, N.C.W., Bartlett, J.S., Muruve, D.A. Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors. The Journal of Virology. 2002 May;76(9):4580-90. Deleon, M.J., Horani, M.H., Haas, M.J., Wong, N.C.W., Mooradian, A.D. Effects of dehydroepiandrosterone on rat apolipoprotein AI gene expression in the human hepatoma cell line, HepG2. Metabolism. 2002 Mar;51(3):376-9. Bowen, G.P., Borgland, S.L., Lam, M., Libermann, T.A., Wong, N.C.W., Muruve, D.A. Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B. Human Gene Therapy. 2002 Feb 10;13(3):367-79. Drover, V.A., Wong, N.C.W., Agellon, L.B. A distinct thyroid hormone response element mediates repression of the human cholesterol 7alpha-hydroxylase (CYP7A1) gene promoter. Molecular Endocrinology. 2002 jan;16(1):14-23. Namihira, H., Sato, M.., Murao, K., Matsubara, s., Imachi, H., Niimi, M., Dobashi, H., Cao, W., Wong, N.C.W., Ishida, T., (2002). Menin, multiple endocrine neoplasia type I gene product inhibits human prolactin gene promoter activity. submitted . Cao, W., Murao, K., Imachi, H., Chiharu, H., Abe, H., Sato, M., Wong, N.C.W., Takahara, J., Ishida, T., (2002). Phosphatidylserine Receptor in Recognition of Apoptotic cells by Thymic Nurse Cells or Nursing Thymic Epithelial Cells. Arteriosclerosis Thrombosis and Vascular Biology, revisions submitted. Matsubara, S., Lam, J.K., Mihara, K., Zheng, X.-L., Mooradian, A.D., and Wong, N.C.W., (2002). Insulin Induction of Apo AI: Role of Sp1. Submitted. Haas, M.J., Sawaf, R., Horani, M.H., gobal, F., Wong, N.C.W., Mooradian, A.D. (2002). Effect of Chromium on Apo AI Expression in Hep G2 cells. Submitted. Samson, S.A. and Wong, N.C.W. Role of Sp1 in Insulin Regulation of Gene Expression. In press. Mooradian, A.D., Wadud, K., Haas, M.J., and Wong, N.C.W. (2002) The Effect of Antioxidants on the Apolipoprotein A-I (Apo-AI) Expression in the Cultured Hepatoma cell line-HepG2., submitted.