个人简介

Ph.D. (Doctor of Philosophy)

研究领域

Molecular Biology and Disease Cell Signalling and Structure

My research focuses on human mitochondria, essential organelles best known for generating both energy and reactive oxygen species (ROS). However, mitochondria are also key regulators of many other important cellular functions and their dysfunction has been implicated in a broad spectrum of human disorders and aging. My research interests comprise two key aspects of mitochondria, mitochondrial dynamics and mitochondrial DNA (mtDNA).

近期论文

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ROMO1 Is an Essential Redox-Dependent Regulator of Mitochondrial Dynamics.Norton M, Ng A., Baird S., Dumoulin A., Shutt T., Mah N., Andrade-Navarro ME, McBride HM, Screaton RA. Sci Signal. 2014 Jan 28;7(310):ra10. Staying cool in difficult times: Mitochondrial dynamics, quality control and the stress response.Shutt TE, McBride HM. Biochim Biophys Acta. 2013 Feb;1833(2):417-24. The intracellular redox state is a core determinant of mitochondrial fusion. Shutt T, Geoffrion M, Milne R, McBride HM. EMBO Rep. 2012 Oct;13(10):909-15. Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause DeafnessRaimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS. Cell. 2012 Feb 17;148(4):716-26. Mitochondrial Ribosomal Protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription. Surovtseva YV, Shutt TE, Cotney J, Cimen H, Chen SY, Koc EC, Shadel GS.Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17921-6. The core human mitochondrial transcription initiation complex: It only takes two to tango.Shutt TE, Bestwick M, Shadel GS. Transcription. 2011 Mar;2(2):55-59. Core human mitochondrial transcription apparatus is a regulated two-component system.Shutt TE, Lodeiro FM, Cotney J, Cameron CE and Shadel GS. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12133-8. A compendium of the human mitochondrial gene expression machinery with links to disease. Shutt TE and Shadel GS. Environ Mol Mutagen. 2010 Jun;51(5):360-79. Ancient mtDNA genetic variants modulate mtDNA transcription and replication. Suissa S, Wang Z, Poole J, Wittkopp S, Feder J, Shutt TE, Wallace DC, Shadel GS and Mishmar D. PLoS Genet. 2009 May;5(5):e1000474. Expanding the mitochondrial interactome. Shutt TE and Shadel GS. Genome Biology. 2007;8(2):203. Homologs of mitochondrial transcription factor B, sparsely distributed within the eukaryotic radiation, are likely derived from the dimethlyadenosine methyltransferase of the mitochondrial endosymbiont. Shutt TE and Gray MW. Molecular Biology and Evolution. 2006 Jun;23(6):1169-1179. Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotes. Shutt TE and Gray MW. Journal of Molecular Biology. 2006 May;62(5):588-599. Bacteriophage origins of mitochondrial replication and transcription proteins. Shutt TE and Gray MW. Trends in Genetics. 2006 Feb;22(2):90-95. An ancient spliceosomal intron in the ribosomal protein L7a gene (Rpl7a) of Giardia lamblia. Shutt TE, Russell AG, Watkins RF, Gray MW. BMC Evolutionary Biology. 2005 Aug 18;5:45.