个人简介

B.Sc. (Bachelor of Science) Ph.D. (Doctor of Philosophy)

研究领域

Molecular Biology and Disease

We have found that treatment of many types of cancer cell with oncolytic virus causes apoptosis, but some cancers can acquire resistance. We are seeking to understand this resistance so that strategies to avoid or reverse it may be developed. We are also investigating genomic evolution in cancer and in model bacteria as an indicator of disrupted regulatory pathways.

近期论文

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Kaewpiboon C, Srisuttee R, Malilas W, Moon J, Oh S, Jeong HG, Johnston RN, Assavalapsakul W, Chung YH. 2015. Upregulation of Stat1-HDAC4 confers resistance to etoposide through enhanced multidrug resistance 1 expression in human A549 lung cancer cells. Mol Med Rep11: 2315-21. Hamano S, Mori Y, Kataoka H, Tanaka M, Ebi M, Kubota E, Mizoshita T, Tanida S, Johnston RN, Asai K, Joh T. 2015. Oncolytic reovirus combined with trastuzumab enhances antitumor efficacy through TRAIL signaling in human HER2-positive gastric cancer cells. Cancer Lett 356: 846-54. Roberts JN, Karvonen C, Graham K, Weinfeld M, Joy AA, oebel M, Morris D, Robson PJ,Johnston RN, Brockton NT. 2015. Biobanking in the Twenty-First Century: driving Population metrics into biobanking quality. In ‘Biobanking in the 21st Century, Advances in Experimental Medicine and Biology’ F. Karimi-Busheri (ed.), Springer, pp 95-114. Wang CX, Zhu SL, Wang XY, Feng Y, Li B, Li YG, Johnston RN, Liu GR, Zhou J, Liu SL. 2015. Complete genome sequence of Salmonella enterica subspecies arizonae str RKS2983. Stand Genomic Sci 10:30. Sanderson KE, Liu SL, Tang L, Johnston RN. 2014. Salmonella Typhi and Salmonella Paratyphi A. Molecular Medical Microbiology, 2nd Edition, Chapter 80, Tang YW (editor), Elsevier. Kaewpiboon C, Srisuttee R, Malilas W, Moon J, Oh S, Jeong HG, Johnston RN, Assavalapsakul W, Chung YH. 2014. Extract of Bryophyllum laetivirens reverses etoposide resistance in human lung A549 cancer cells by downregulation of NF-kB. Oncol Reports 31: 161-68. Sanderson KE, Liu SL, Tang L, Johnston RN. 2014. Salmonella Typhi and Salmonella Paratyphi A. Molecular Medical Microbiology, 2nd Edition, Chapter 71, Tang YW, Sussman M, Liu D, Poxton I, Schwartzman J (editors), Elsevier, pp. 1275-1306. Watson PH, Nussbeck SY, Carter C, O’Donoghue S, Cheah S, Matzke LAM, Barnes RO, Bartlett J, Carpenter J, Grizzle WE, Johnston RN, Mes-Masson AM, Murphy L, Sexton K, Shepherd L, Simeon-Dubach D, Zeps N, Schacter B. 2014. A framework for Biobank sustainability. Biopres Biobank 12: 60-68. Malilas W, Koh SS, Lee S, Srisuttee R, Cho IR, Moon J, Kaowinn S, Johnston RN, Chung YH. 2014. Suppression of autophagic genes sensitizes CUG2-overexpressing A549 human lung cancer cells to oncolytic vesicular stomatitis virus-induced apoptosis. Int J Oncol 44: 1177-84. Kaewpiboon C, Surapinit S, Malilas W, Moon J, Phywapraisirisan P, Tip-Pyang S, Johnston RN, Koh SS, Assavalapsakul W, Chung YH. 2014. Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells. Int J Oncol 44: 1233-42. Bao HX, Tang L, Yu L, Wang XY, Li Y, Deng X, Li YG, Li A, Zhu DL, Johnston RN, Liu GR, Feng Y, Liu SL. Differential efficiency in exogenous DNA acquisition among closely related Salmonella strains: implications in bacterial speciation. 2014. BMC Microbiol 14: 157-167. Tang L, Liu WQ, Fang X, Sun Q, Zhu SL, Wang CX, Li YG, Zhu DL, Sanderson K, Johnston RN, Liu GR, Liu SL. 2014. CTAG-containing cleavage site profiling to delineate Salmonella into natural clusters. PLOS One 9: e103388. Albert M, Bartlett J, Johnston RN, Schacter B, Watson P. 2014. Biobank bootstrapping: is biobank sustainability possible through cost recovery? Biopreserv Biobank 12: 374-80. Watson PH, Nussbeck SY, Carter C, O’Donoghue S, Cheah S, Matzke LAM, Barnes RO, Bartlett J, Carpenter J, Grizzle WE, Johnston RN, Mes-Masson AM, Murphy L, Sexton K, Shepherd L, Simeon-Dubach D, Zeps N, Schacter B. 2014. A framework for Biobank sustainability. Biopres Biobank (in press). Malilas W, Koh SS, Lee S, Srisuttee R, Cho IR, Moon J, Kaowinn S, Johnston RN, Chung YH. 2014. Suppression of autophagic genes sensitizes CUG2-overexpressing A549 human lung cancer cells to oncolytic vesicular stomatitis virus-induced apoptosis. Int J Oncol 44: 1177-84. Kaewpiboon C, Surapinit S, Malilas W, Moon J, Phywapraisirisan P, Tip-Pyang S, Johnston RN, Koh SS, Assavalapsakul W, Chung YH. 2014. Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells. Int J Oncol 44: 1233-42. Malilas W, Koh SS, Srisuttee R, Boonying W, Cho IR, Jeong CS, Johnston RN, Chung YH. 2013. Cancer up-regulated gene (CUG) 2, a novel oncogene confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling. Cancer Gene Therapy 20: 125-32. Liu J, Guo JT, Li YG, Johnston RN, Liu GR, Liu SL. 2013. The type VI secretion system gene cluster of Salmonella typhimurium: required for full virulence in mice. J Basic Microbiol 53: 600-07. Feng Y, Johnston RN, Liu GR, Liu SL. 2013. Genomic comparison between Salmonella gallinorum and pullorum: differential pseudogene formation under common host restriction.PLoS ONE 8: Mar 15. e59427. Wong H, Soh J, Gordon PMK, Yu T, Sensen CW, Parr E, Johnston RN. 2013. Genomic compartmentalization of gene families encoding core components of metazoan signaling systems. Genome 56: 215-225.