个人简介

Ph.D. (Doctor of Philosophy)

研究领域

Molecular and Development Genetics Molecular Biology and Disease

Our lab studies the control of cell tissue growth using Drosophila as a model system. We use a combination of molecular, genetic and proteomic approaches to investigate the cell-cell signalling pathways and the genetic mechanisms that control how cell, tissue and body growth is controlled. Our main focus to-date has been the insulin and TOR kinase pathways. In animals, a complex signal transduction network activates the insulin/TOR pathways in response to growth factors and nutrient availability. Many oncogenes and tumor suppressors are components of this network. As a consequence of this elevated TOR activity is a common feature of tumour cells and may contribute to deregulated cell growth in cancer. The TOR pathway has therefore emerged as a promising target for therapy. Although the signalling inputs to TOR are becoming clear, the outputs via which TOR drives cell growth are still not fully understood. TOR controls many metabolic processes, such as protein synthesis, nutrient import, glucose metabolism, autophagy, and gene transcription. Our research is aimed at defining which downstream targets are critical for TOR function, which should provide insights into both normal and tumour cell growth.

近期论文

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Grewal SS (2015) Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth. Biochim Biophys Acta Ghosh A, Rideout EJ, Grewal SS (2014) ¬¬TIF-IA-dependent regulation of ribosome synthesis inDrosophila muscle is required to maintain systemic insulin signaling and larval growth. PloS Genetics 10(10):e1004750 Nagarajan S and Grewal SS (2014) An investigation of nutrient-dependent mRNA translation in Drosophila larvae. Biology Open, 3(11):1020-31 Killip LE and Grewal SS (2012) DREF controls tissue and organismal growth in Drosophila downstream of nutrition/TOR signaling. Developmental Biology 2012, 371, 191 Rodrigues AB, Ayala-Camargo A, Grewal SS, Reyes-Robles T, Krasny M, Wu DC, Johnston LA, and Bach E. Activated (2012) Stat is a supercompetitor that acts independently of Myc, Yorkie, Wingless and ribosome biogenesis. Development 2012, 139, 4051 Grewal SS (2012) Controlling growth and body size – fruit fly physiology points the way. F1000 Reports 4:12 Marshall L, Rideout EJ, Grewal SS (2012) Nutrient-TOR dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. EMBO J, 31:1916 Rideout EJ, Marshall L, Grewal SS. (2012) Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling Proc Natl Acad Sci U S A. 109(4):1139-44 Zielke N, Kim KJ, Tran V, Shibutani ST, Bravo MJ, Nagarajan S, van Straaten M, Woods B, von Dassow G, Rottig C, Lehner CF, Grewal SS, Duronio RJ, Edgar BA (2011) Control of Drosophila endocycles by E2F and CRL4CDT2. Nature, 480, 123. Li L, Edgar B.A.E, Grewal S.S. (2010) Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element. BMC Cell Biology. 11, 7 Grewal S.S. (2009) The insulin/TOR pathway in growth and homeostasis: A view from the fly world. Int J Biochem Cell Biol. 41, 1006.