Vice Chancellor for Strategic Initiative, Boyd Professor and Philip W. West Professor of Analytical and Environmental Chemistry, Howard Hughes Medical Institute Professor
Our research involves a problem solving approach to answering fundamental questions in chemistry, as well as development and application of novel strategies (chemical, instrumental, and mathematical) for measurement science. The overall goal of our research is to provide improved strategies to provide answers to important questions of chemical origin using the problem solving approach common to analytical measurements. Although the primary focus of our research is in the broad area of chemistry, most of our studies emphasize the more specific areas of analytical, materials, and environmental sciences, with a strong emphasis on bioanalytical chemistry. Some examples of current research projects are provided below.
development of ionic liquids (ILs) and GUMBOS (group of uniform materials based on organic salts) for applications in materials, biomedical, and bioanalytical chemistry;
synthesis and production of nanoparticles (particularly nanoGUMBOS) for novel biomedical applications and bioanalytical measurements;
development of novel analytical schemes for protein analyses, particularly those relevant to MALDI and SDS-PAGE analyses;
development of sensors and sensor arrays using ionic liquids and GUMBOS for rapid bioanalytical measurements;
studies of the influence and applications of guest/host chemistry, e.g., organized media, to chemical systems of analytical interests;
development and application of molecular spectroscopy, particularly absorption and fluorescence, for bioanalytical measurements.
Kamande, Mary W.; Ross, David; Locascio, Laurie E.; Lowry, Mark; Warner, Isiah M. Simultaneous concentration and separation of coumarins using a molecular micelle in micellar affinity gradient focusing. Analytical Chemistry (2007), 79(5), 1791-1796
Yang, Y.; Lowry, M.; Schowalter, C.M.; Escobedo, J.O.; Fakayode, S.O.; Xu, X.; Zhang, H.; Jensen, T.J.; Fronczek, F.R.; Warner, I.M.; Strongin, R.M.. An Organic White Light-Emitting Fluorophore, Journal of the American Chemical Society, (2006), 128, 14081-14092.
Tesfai, Aaron, El-Zahab, Bilal, Bwambok, David, Baker, Gary A., Fakayode, Sayo O., Lowry, Mark, Warner, Isiah M., “Controllable Formation of Ionic Liquid Micro- and Nanoparticles via Melt-Emulsion-Quench Approach,” Nanoletters, 8(3), 897-901, 2008.
Gates, Arther, Fakayode, Sayo, Lowry, Mark, Ganea, Gabriela, Murugeshu, Abitha, Robinson, James, Strongin, Robert, Warner, Isiah, “Gold Nanoparticle Biosensor for Homocysteine Thiolactone-Induced Protein Modification,” Langmuir, 24(8), 4107-4113 (2008).