王瑞兵 - 澳门大学 - 中华医药研究院

个人简介

Academic Qualifications Ph.D. (2007) in Organic Chemistry, Queen’s University, Canada Advisor: Prof. Donal H. Macartney, Professor of Chemistry B.Sc. (2002) in Chemistry (Gifted Class), Jilin University, China Advisor: Prof. Bai Yang, Professor of Chemistry and Materials Science Working Experience Aug 2019-Present, Associate Professor of Supramolecular Pharmaceutics and Nanomedicine, Institute of Chinese Medical Sciences,University of Macau, Taipa, Macau SAR, China Oct 2014-Aug 2019, Assistant Professor of Supramolecular Pharmaceutics and Nanomedicine, Institute of Chinese Medical Sciences,University of Macau, Taipa, Macau SAR, China Nov 2009-Oct 2014, Senior Scientist, BTG plc. (Canadian branch, formerly a part of Nordion Inc., now part of Boston Scientific), Ottawa, Canada May 2008–Nov 2009, Associate Research Officer (started as a Research Associate) at Steacie Institute for Molecular Sciences,National Research Council of Canada, Ottawa, Canada Aug 2007-May 2008, Postdoctoral Fellow, Department of Chemistry at Queen’s University, Canada

研究领域

Supramolecular Pharmaceutics/Medicine We are interested in supramolecular interactions between macrocyclic molecules (such as cucurbiturils, cyclodextrins, pillararenes and calixarenes) and synthetic/natural drugs, with intentions to explore the beneficial roles of these macrocycles as emerging excipients for enhancing water solubility, stability, transcellular activity, and ultimately therapeutic efficacy with reduced side effects of guest medicines. In many cases, these macrocycles may act as reversal agents (or antidotes) towards toxic effects of guest drugs. Our collaborators include colleagues here at UM, as well as external scientists from Canada, France, USA, Hong Kong and mainland China. Supramolecular Biomaterials We intend to incorporate high potency ingredients (e.g. particularly those of natural products) into stimuli-responsive supramolecularly self-assembled materials for various biomedical applications such as precision medicine, controlled drug release and interventional medicine for targeted therapy. These material matrices include natural polysaccharides, natural and synthetic macrocycles and their derivatives. By placing real-world clinical applications as our study aim, we work closely with scientists and clinicians in the region and around the world. Biomimetic Drug Delivery Constantly inspired by Nature and ancient principles of Chinese medicine, we are highly interested in developing biomimetic drug delivery systems, particularly those based on supramolecular assembly, for improved therapeutics in a variety of diseases, such as inflammatory diseases, infections and cancers.

近期论文

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Xiaoju Men, Haobin Chen, Chen Sun, Yubin Liu, Ruibing Wang, Xuanjun Zhang, Changfeng Wu, and Zhen Yuan* “Thermosensitive Polymer Dot Nanocomposites for Trimodal Computed Tomography/Photoacoustic/Fluorescence Imaging-Guided Synergistic Chemo-Photothermal Therapy,” ACS Appl. Mater. Interfaces, 2020, https://dx.doi.org/10.1021/acsami.0c13252, in press. Yuan Chen, Lulu Fu, Baobao Sun, Cheng Qian, Srikala Pangannaya, Hong Zhu, Jing Ma, Juli Jiang,* Zhigang Ni, Ruibing Wang, Xiancai Lu and Leyong Wang,* “Selection of Planar Chiral Conformations between Pillar[5,6]arenes Induced by Amino Acid Derivatives in Aqueous Media,” Chemistry – A European Journal, 2020, DOI:10.1002/chem.202004003, in press. Shuwen Guo, Qiaoxian Huang, Yuan Chen, Jianwen Wei, Jun Zheng, Leyong Wang, Yitao Wang and Ruibing Wang,* “Synthesis and Bioactivity of Guanidinium‐Functionalized Pillar[5]arene as a Biofilm Disruptor,” Angewandte Chemie International Edition, 2020, DOI:10.1002/anie.202013975, in press. Hang Yin, David Bardelang* and Ruibing Wang,* “Macrocycles and congeners as supramolecular antidotes,” Trends in Chemistry, 2020, DOI: 10.1016/j.trechm.2020.08.008, in press. Hang Yin, Xiangjun Zhang, Jianwen Wei, Siyu Lu, David Bardelang,* and Ruibing Wang,* “Recent advances in supramolecular antidotes,” Theranostics, 2020, DOI:10.7150/thno.53459, in press. Ludan Yue, Kuikun Yang, Xin-Yue Lou, Ying-Wei Yang* and Ruibing Wang,* “Versatile roles of macrocycles in organic-inorganic hybrid materials for biomedical applications,” Matter, 2020, 3, 1557–1588. Chen Sun, Ziyi Wang, Ludan Yue, Qiaoxian Huang, Qian Cheng and Ruibing Wang,* “Supramolecular Induction of Mitochondrial Aggregation and Fusion,” Journal of the American Chemical Society, 2020, 142, 16523–16527. Chen Sun, Ziyi Wang, Ludan Yue, Qiaoxian Huang, Siyu Lu* and Ruibing Wang,* “ROS-initiated Chemiluminescence-driven Payload Release from Macrocycle-Based Azo-containing Polymer Nanocapsules,” Journal of Materials Chemistry B, 2020, 8, 8878-8883. Lele Ma, Quan Tang, Ming-Xuan Liu, Xu-Ying Liu, Jin-Yu Liu, Zhong-Lin Lu,* Yong-Guang Gao,* and Ruibing Wang,* “[12]aneN3-based Gemini-type Amphiphiles with Two-photon Absorption Properties for Enhanced Non-viral Gene Delivery and Bioimaging,” ACS Applied Materials & Interfaces, 2020, 12, 40094–40107. Qiaoxian Huang, Hong Zhao, Mingju Shui, Dong-Sheng Guo* and Ruibing Wang,* “Heparin Reversal by an Oligoethylene Glycol Functionalized Guanidinocalixarene,” Chemical Science, 2020, 11, 9623-9629. Cheng Gao, Qian Cheng, Jianwen Wei, Chen Sun, Siyu Lu, Cheryl H.T. Kwong, Simon M.Y. Lee, Zhiyuan Zhong* and Ruibing Wang,* “Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery,” Materials Today, 2020, DOI: 10.1016/j.mattod.2020.05.023, in press. Xue Yang, Ruibing Wang,* Anthony Kermagoret,* and David Bardelang,* “Oligomeric Cucurbituril Complexes: from Peculiar Assemblies to Emerging Applications,” Angewandte Chemie International Edition, 2020, DOI: 10.1002/anie.202004622, in press. Tianlei Sun, Cheryl H. T. Kwong, Cheng Gao, Jianwen Wei, Ludan Yue, Jianxiang Zhang, Richard Dequan Ye* and Ruibing Wang,* “Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine,” Theranostics, 2020, 10, 10106-10119. Yan-Long Ma, Mao Quan, Xiu-Lian Lin, Qian Cheng, Huan Yao, Xi-Ran Yang, Ming-Shuang Li, Wei-Er Liu, Lin-Ming Bai, Ruibing Wang,* and Wei Jiang,* “Biomimetic Recognition of Organic Drug Molecules in Water by Amide Naphthotubes,” CCS Chemistry, 2020, 2, 1-16. Linting Li, Min Liu, Ludan Yue, Rui Wang, Ning Zhang, Yujie Liang, Liang Zhang, Lixin Cheng,* Jiang Xia,* and Ruibing Wang,* “Host–Guest Protein Assembly for Affinity Purification of Methyllysine Proteomes,” Analytical Chemistry, 2020, 92, 9322-9329. Ting Shu, Muhan Huang, Di Wu, Yujie Ren, Xueyi Zhang, Yang Han, Jingfang Mu, Ruibing Wang, Yang Qiu, Ding-Yu Zhang, and Xi Zhou*, “SARS-coronavirus-2 nsp13 possesses NTPase and RNA helicase activities that can be inhibited by bismuth salts,” Virologica Sinica, 2020, 35, 321-329. Phoebe C.I. Ng, Judy Y.W.Chan, Ross K.K. Leung, J. Li, Z. Ren, Anthony W.H. Chan, Xu, S.S. Lee, Ruibing Wang, Xia Ji, Jun Zheng, Denise P.C. Chan, W.W. Yew, and Simon M.Y. Lee, “Role of oxidative stress in clofazimine-induced cardiac dysfunction in a zebrafish model,” Biomedicine & Pharmacotherapy, 2020, 132, 110749. Weirui Qian, Minzan Zuo, Guangping Sun, Yuan Chen, Tingting Han, Xiao-Yu Hu,* Ruibing Wang and Leyong Wang,* “The Construction of AIE-Based Controllable Singlet Oxygen Generation System Directed by Supramolecular Strategy,” Chemical Communications, 2020, 56, 7301-7304. Cheng Gao, Cheryl H. T. Kwong, Chen Sun, Zheng Li, Siyu Lu, Ying-Wei Yang,* Simon Ming-Yuen Lee*, and Ruibing Wang*, “Selective Decoating-Induced Activation of Supramolecularly Coated Toxic Nanoparticles for Multiple Applications,” ACS Appl. Mater. Interfaces, 2020, 12, 25604–25615. Cheng Gao, Qiaoxian Huang, Conghui Liu, Cheryl H.T Kwong, Ludan Yue, Jian-Bo Wan, Simon M. Y. Lee* and Ruibing Wang,* “Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines,” Nature Communications, 2020, 11, 2622. Highlighted by Nature Review Cardiology, 2020, https://doi.org/10.1038/s41569-020-0404-x. Chen Sun, Ludan Yue, Qian Cheng, Ziyi Wang and Ruibing Wang,* “Macrocycle-Based Polymer Nanocapsules for Hypoxia-Responsive Payload Delivery,” ACS Materials Letters, 2020, 2, 266-271.