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个人简介

Xiao was born and raised in Linyi, Shandong, China. He received his B.S. degree in Applied Chemistry from Shandong Normal University (2008) in Jinan, Shandong, where he was mentored by Prof. Qingjian Liu (刘庆俭教授). After moving to Shanghai, he completed his Ph.D. at Shanghai Institute of Organic Chemistry (2013) with Prof. Jinbo Hu (胡金波研究员). After a half year stay as a research associate at SIOC, he moved to Boston for postdoctoral studies with Prof. Tobias Ritter at Harvard University and Prof. Amir H. Hoveyda at Boston College. In August 2017, Xiao accepted an appointment at Wuhan University, where he is a professor in the Institute for Advanced Studies. EDUCATION AND RESEARCH EXPERIENCE Professor 08/2017 The Institute for Advanced Studies, Wuhan University, Wuhan, China Post-Doctoral Associate 06/2015−07/2017 Department of Chemistry, Merkert Chemistry Center, Boston College, MA, USA Advisor: Prof. Amir H. Hoveyda Post-Doctoral Fellow 02/2014−05/2015 Department of Chemistry and Chemical Biology, Harvard University, MA, USA Advisor: Prof. Tobias Ritter Research Associate 07/2013−02/2014 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China. Advisor: Prof. Jinbo Hu Ph.D. Organic Chemistry 2013 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China Advisor: Prof. Jinbo Hu B. S. Chemistry 2008 Shandong Normal University, Jinan, P. R. China

研究领域

催化有机合成方法学:新型催化剂的设计合成和催化反应研究 元素有机化学:基于硅/氟元素的有机化学反应及其在重要生物活性分子和功能材料中的合成应用研究

近期论文

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Y. Zhang#, Y. Niu#, Y. Guo, J. Wang, Y. Zhang, S. Liu, X. Shen*. "Photocatalyzed Cascade Reactions of Cyclopropanols and α-Trifluoromethyl-Substituted Olefins for the Synthesis of Fused gem-Difluorooxetanes" Angew. Chem. Int. Ed. DOI: 10.1002/anie.202212201. P. Jin, X. Shen*. "SulfoxFluor as a deoxyfluorination reagent, and beyond" J. Fluorine Chem. 2022, 261-262: 110029. Z. Zhu, W. Zhang, Y. Zhang, S. Liu, and X. Shen.*''Visible-Light-Induced [4+1] Cyclization-Aromatization of Acylsilanes and ɑ, β-Unsaturated Ketones'' CCS Chemistry. 2022, DOI: 10.31635/ccschem.022.202202199. S. Chen, X. He, Y. Jin, Y. Lan,* X. Shen.* ''Copper-Catalyzed Regio- and Stereo-Selective Hydrosilylation of Terminal Allenes to Access (E)-Allylsilanes'' Nat. Commun, 2022, 13 (1): 3691. G. Zhou, X. Shen.* '' Visible-Light-Induced Organocatalyzed [2+1] Cyclization of Alkynes and (Trifluoroacetyl)silanes'' Synlett 2022, DOI: 10.1055/a-1840-5199. (Invited Synpacts). Y. Zhang, # G. Zhou, # X. Gong, # Z. Guo, X. Qi, * X. Shen.* ''Diastereoselective Transfer of Tri(di)fluoroacetylsilanes-Derived Carbenes to Alkenes'' Angew. Chem. Int. Ed. 2022, 61, e202202175. (#contributed equally). Y. Zhang, Y. Zhang, Y. Guo, S. Liu, X. Shen.* ''Reductive Quenching-Initiated Catalyst-Controlled Divergent Alkylation of α-CF3-Olefin'' Chem Catal. 2022, accepted. X. He, Y. Zhao, Z. Zhang, X. Shen.* “Tuning the Reactivity of Alkoxyl Radicals from Cyclization to 1,2-Silyl Transfer: Stereoselective Synthesis of β-Substituted Cycloalcohols” Org. Lett. 2022, 24, 1991-1995. X. Fang, # W. Wen, # P. Jin, W. Bao, S. Liu, H. Cong, X. Shen.* '' Synthesis of Enantioenriched Fluorinated Enol Silanes Enabled by Asymmetric Reductive Coupling of Fluoroalkylacylsilanes and 1,3-Enynes and Brook Rearrangement'' Acs Catal. 2022, 12, 2150-2157. (#contributed equally). G. Zhou, X. Shen.* ''Synthesis of Cyclopropenols Enabled by Visible-Light-Induced Organocatalyzed [2+1] Cyclization'' Angew. Chem. Int. Ed. 2022, 61, e202115334. (Highlighted by Synfacts) X. Chen, Z. Zhu, S. Liu, Y.-H. Chen, X. Shen.* '' MnBr2 catalyzed regiospecific oxidative Mizoroki-Heck type reaction.'' Chin. Chem. Lett. 2021, accepted. https://doi.org/10.1016/j.cclet.2021.10.083. (Invited contribution to the special collection on “Fluorine Chemistry”.) Z. Zhu, X. Chen, S. Liu, J. Zhang, X. Shen.* '' Synthesis of 1-Tri(di)fluoromethyl 1,4-Diketones Enabled by Radical Brook Rearrangement.'' Eur. J. Org. Chem. 2021, 4927. (Invited contribution to the special collection on “Silicon Chemistry in Organic Synthesis” Selected as Very Important Paper by the Editor). Y. Zhang, Y. Zhang, X. Shen.* ''Alkoxyl Radical-Mediated Synthesis of Functionalized Allyl tert-(Hetero)cyclobutanols and Their Ring-opening and Ring-expansion Functionalizations.'' Chem Catal. 2021, 1(2), 423. Z. Yang#, Y. Niu# , X. He, S. Chen, S. Liu, Z. Li, X. Chen, Y. Zhang, Y. Lan*, X. Shen.* ''Tuning the Reactivity of Alkoxyl Radicals from 1,5-Hydrogen Atom Transfer to 1,2-Silyl Transfer'' Nat. Commun. 2021, 12, 2131. X. Chen#, X. Gong#, Z. Li, G. Zhou, Z. Zhu, W. Zhang, S. Liu, X. Shen.* "Direct transfer of tri- and di-fluoroethanol units enabled by radical activation of organosilicon reagents" Nat. Commun. 2020, 11, 2756. (# contributed equally; Highlighted by Synfacts). Y. Zhang#, Y. Chen#, Z. Zhang, S. Liu, X. Shen.* “Synthesis of Stereodefined Trisubstituted Alkenyl Silanes Enabled by Borane Catalysis and Nickel Catalysis” Org. Lett 2020, 3, 970-975. Y. Li, X. Chen, X. Chen, X. Shen.* "Organophosphine-Catalyzed [4C+X] Annulations" Molecules 2018, 23(11), 3022 (Invited contribution to the Special Issue Sustainable Synthesis) X. Shen, T. T. Nguyen, M. J. Koh, D. Xu, A. W. H. Speed, R. R. Schrock, A. H. Hoveyda.* “Kinetically E-Selective Macrocyclic Ring-closing Metathesis”Nature 2017, 541, 380-385. C. Xu,# X. Shen,# A. H. Hoveyda.* “In situ Methylene Capping: A General Strategy for Efficient Stereo-Retentive Catalytic Olefin Metathesis. The Concept, Methodological Implications and Applications to Synthesis of Biologically Active Compounds” J. Am. Chem. Soc. 2017, 139, 10919-10928. C. Xu, Z. Liu, S. Torker, X. Shen, D. Xu, A. H. Hoveyda.* “Synthesis of Z- or E-Trisubstituted Allylic Alcohols and Ethers by Kinetically Controlled Cross-Metathesis with a Ru Catechothiolate Complex” J. Am. Chem. Soc. 2017, 139, 15640-15643.

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