个人简介
王慧贞 博士,副教授,硕士生导师
学习工作经历
2010.09-2014.06 ,山东师范大学,生物科学,学士
2014.09-2017.06 ,中国海洋大学,海洋生物学,硕士
2017.09-2021.06 ,中国海洋大学,遗传学,博士
2021.07-2024.02 ,中国海洋大学海洋生命学院,博士后
2024.02 至今,中国海洋大学海洋生命学院,“青年英才工程第三层次”,副教授
主要研究领域及成果
致力于海洋贝类遗传育种研究,聚焦贝类经济性状遗传机制解析与育种应用。利用遗传学、分子生物学、细胞生物学和功能基因组学等技术,揭示海洋贝类重要经济性状的遗传基础及调控机理,为高产、优质贝类良种的选育提供理论支撑和技术支持。近年来以首作者/ 通讯作者(含共同)发表 SCI 论文 10余篇,主持承担了国家自然科学基金青年基金、山东省自然科学基金青年基金、国家重点研发计划项目子课题、青岛市博士后应用研究项目等课题项目,参与国家和省部级项目 6项。参与培育优质高产栉孔扇贝新品种“蓬莱红 3 号”,产业效益显著。
研究领域
致力于海洋贝类遗传育种研究,聚焦贝类经济性状遗传机制解析与育种应用。利用遗传学、分子生物学、细胞生物学和功能基因组学等技术,揭示海洋贝类重要经济性状的遗传基础及调控机理,为高产、优质贝类良种的选育提供理论支撑和技术支持。
近期论文
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1) Yihan Zhang#, Huizhen Wang# , Shiqi Liu, Xiangfu Kong, Lirong Chang, Liang Zhao, Zhenmin Bao, Xiaoli Hu*. Multi-tissue metabolomic profiling reveals the crucial metabolites and pathways associated with scallop growth. BMC Genomics 2024, 25(1):1091.
2) Shiqi Liu#, Shuyue Wang#, Liang Zhao, Tingting Li, Yihan Zhang, Huizhen Wang*, Zhenmin Bao, Xiaoli Hu*. Functional analysis of β-carotene oxygenase 2 ( BCO2 ) gene in Yesso scallop ( Patinopecten yessoensis ). International Journal of Molecular Sciences 2024, 25(7):3947.
3) Xiangchao Zhang#, Xiaogang Xun#, Deting Meng, Moli Li, Lirong Chang, Jiaoxia Shi, Wei Ding, Yue Sun, Huizhen Wang*, Zhenmin Bao, Xiaoli Hu * . Transcriptome analysis reveals the genes involved in oxidative stress responses of scallop to PST-producing algae and a candidate biomarker for PST monitoring. Antioxidants 2023, 12(6):1150.
4) Tingting Li#, Yihan Zhang#, Shiqi Liu, Moli Li, Ruixing Yao, Senyu Niu, Jingyao Yuan, Huizhen Wang*, Jingjie Hu, Zhenmin Bao, Xiaoli Hu * . Transcriptome and network analyses reveal key pathways and genes involved in response to carotenoid deposition in scallop muscle. Frontiers in Marine Science 2023, 10:1158325.
5) Yujue Wang#, Moli Li#, Jiarun Lou, Xiaogang Xun, Lirong Chang, Yangrui Wang, Quanqi Zhang, Longfei Lu, Huizhen Wang*, Jingjie Hu, Zhenmin Bao, Xiaoli Hu * . Transcriptome and network analyses reveal the gene set involved in PST accumulation and responses to toxic Alexandrium minutum exposure in the gills of Chlamys farreri . International Journal of Molecular Sciences 2022, 23(14):7912.
6) Moli Li, Yangrui Wang, Zhihong Tang, Huizhen Wang*, Jingjie Hu, Zhenmin Bao, Xiaoli Hu. Expression plasticity of peroxisomal acyl-coenzyme A oxidase genes implies their involvement in redox regulation in scallops exposed to PST-producing Alexandrium . Marine Drugs 2022, 20(8):472.
7) Shuyue Wang#, Huizhen Wang# , Liang Zhao#, Yihan Zhang, Tingting Li, Shiqi Liu, Jiaoxia Shi, Shanshan Lian, Jingjie Hu, Zhenmin Bao, Xiaoli Hu * . Identification of genes associated with carotenoids accumulation in scallop ( Patinopecten yessoensis ). Aquaculture 2022, 550:737850.
8) Huizhen Wang , Shiqi Liu, Xiaogang Xun, Moli Li, Jiarun Lou, Yihan Zhang, Jiaoxia Shi, Jingjie Hu, Zhenmin Bao, Xiaoli Hu*. Toxin- and species-dependent regulation of ATP-binding cassette (ABC) transporters in scallops after exposure to paralytic shellfish toxin-producing dinoflagellates. Aquatic Toxicology 2021, 230:105697.