罗雄剑 - 东南大学

个人简介

罗雄剑，东南大学教授，博士生导师。入选国家海外高层次引进人才并获基金委优秀青年科学基金支持。课题组长期致力于精神疾病的遗传机制和功能基因组学研究，利用全基因组范围内的关联研究（GWAS），结合生物信息学、功能基因组学及神经生物学等，从分子、细胞、模式动物和人等多个层次进行重要精神疾病易感基因的功能及其机制研究，主要目标是阐明精神疾病的遗传机制和致病机理，为预防和治疗精神疾病提供诊断及预后的分子标志物以及治疗靶标。目前研究方向主要集中在：1.精神疾病遗传学和功能基因组学；2.精神疾病动物模型建立及致病机理研究；3.精神疾病潜在治疗靶标和抗精神疾病药物研究。相关工作发表于Nature Human Behaviour、Brain、Nature Communications、Advanced Science、Molecular Psychiatry、Biological Psychiatry、Genome Medicine等有国际影响力的学术期刊。目前总共发表SCI论文70余篇，其中第一和通讯作者论文50篇（近5年发表IF 10-20分18篇）。研究成果三度被Faculty of 1000推荐。担任英国医学研究理事会（MRC）抑郁症项目评审专家，任BMC Psychiatry的Associate Editor。

研究领域

神经生物学、遗传学目前研究方向主要集中在：1.精神疾病遗传学和功能基因组学；2.精神疾病动物模型建立及致病机理研究；3.精神疾病潜在治疗靶标和抗精神疾病药物研究。

近期论文

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1. Junyang Wang#, Jiewei Liu, …, Zhijun Zhang, Xiongjian Luo*. Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus. Brain. 2022. doi:10.1093/brain/awac352. 2. Rui Chen#, Zhihui Yang#, Jiewei Liu#, Xin Cai#, …, Ming Li*, Hong Chang*, Xiongjian Luo*. Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants. Genome Medicine. 2022,14(1):53. doi:10.1186/s13073-022-01057-3. 3. Rui Chen#, Jiewei Liu#, …, Ming Li, Xiongjian Luo*. Functional genomics elucidates regulatory mechanisms of Parkinson's disease-associated variants. BMC medicine. 2022, 20(1):68. doi:10.1186/s12916-022-02264-w. 4. Wenqiang Li, Luxian Lv, Xiongjian Luo*. In vivo study sheds new light on the dendritic spine pathology hypothesis of schizophrenia. Molecular Psychiatry. 2022, 27(4):1866-1868. doi:10.1038/s41380-022-01449-2. 5. Junyang Wang, Shiwu Li, Xiaoyan Li, …, Xiao Xiao, Xiongjian Luo*. Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1. Brain. 2022, doi:10.1093/brain/awac020. 6. Yifan Li#, Changguo Ma#, Shiwu Li#, …, Ming Li, Xiongjian Luo*. Regulatory variant rs2535629 in ITIH3 intron confers schizophrenia risk by regulating CTCF binding and SFMBT1 expression. Advanced Science. 2022, 9(6):e2104786. doi:10.1002/advs.202104786. 7. Shiwu Li#, Jiao Li#, Jiewei Liu#, …, Xiao Xiao, Xiongjian Luo*. Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression. Brain. 2021, 145(2):770-786. doi:10.1093/brain/awab357. 8. Yifan Li#, Shiwu Li#, Jiewei Liu, Yongxia Huo, Xiongjian Luo*. The schizophrenia susceptibility gene NAGA regulates dendritic spine density: further evidence for the dendritic spine pathology of schizophrenia. Molecular Psychiatry. 2021, 26(12):7102-7104. doi:10.1038/s41380-021-01261-4. 9. Jiewei Liu#, Xiaoyan Li, Xiongjian Luo*. Proteome-wide association study provides insights into the genetic component of protein abundance in psychiatric disorders. Biological Psychiatry. 2021, 9(11):781-789. doi:10.1016/j.biopsych.2021.06.022. 10. Jiewei Liu#, Shiwu Li, Xiaoyan Li, …, Ming Li, Xiongjian Luo*. Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia. BMC medicine. 2021, 19(1):177. doi:10.1186/s12916-021-02039-9. 11. Yifan Li#, Changguo Ma, Wenqiang Li, …, Ming Li, Xiongjian Luo*. A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression. Molecular Psychiatry. 2021, 26(11):6896-6911. doi:10.1038/s41380-021-01125-x. 12. Shiwu Li#, Yifan Li#, Xiaoyan Li, …, Ming Li, Xiongjian Luo*. Regulatory mechanisms of major depressive disorder risk variants. Molecular Psychiatry. 2020, 25(9):1926-1945. doi:10.1038/s41380-020-0715-7. 13. Yongxia Huo#, Shiwu Li#, Jiewei Liu, Xiaoyan Li, Xiongjian Luo*. Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk. Nature Communications. 2019, 10:670. doi:10.1038/s41467-019-08666-4. 14. Cuiping Yang#, Xiaoyan Li#, Yong Wu#, Qiushuo Shen#, …, Yongbin Chen*, Xiongjian Luo*. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Nature Communications. 2018,9:838. doi:10.1038/s41467-018-03247-3. 15. Xiongjian Luo#*, Chen Zhang#. Down-regulation of SIRT1 in major depressive disorder. American Journal of Psychiatry. 2016, 173(10):1046. doi:10.1176/appi.ajp.2016.16040394. 16. Xiongjian Luo#*, Ming Li#, Liang Huang, …, Bing Su, Lin Gan*. Convergent Lines of Evidence Support CAMKK2 as a Schizophrenia Susceptibility Gene. Molecular Psychiatry. 2014, 19(7):774-783. doi:10.1038/mp.2013.103. 17. Ming Li#, Xiongjian Luo#, Marcella Rietschel, …, CHARGE consortium, Bing Su*. Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Molecular Psychiatry. 2014, 19(4):452-461. doi:10.1038/mp.2013.37.

学术兼职

担任英国医学研究理事会（MRC）抑郁症项目评审专家，任BMC Psychiatry的Associate Editor。