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个人简介

王黎娟,中共党员,2012-2015,中科院深圳先进技术研究院,医药所,助理研究员;2015-2020,山东师范大学,化学化工与材料科学学院,研究员,硕士生导师;2020至今,东南大学,化学化工学院/数字医学工程全国重点实验室,教授,博士生导师。研究领域:探针合成、生物传感和医学成像。主持国家自然科学青年基金1项、面上项目1项,参与国家重点、江苏省前沿技术研发、面上及青年基金项目等7项。获山东省自然科学奖二等奖2项、山东省科技创新大赛二等奖2项。在Nucleic Acids Res., Nano Lett., Chem. Eng. J., Chem. Sci.,Theranostics等著名期刊发表一作/通讯SCI论文49篇,封面论文3篇,JCR一区46篇,H-index25,单篇平均IF为8.45,总被引次数达2000余次。授权国家发明专利10项。2026年硕、博士研究生招生,欢迎报考!待遇优厚!(wanglijuan@seu.edu.cn)

研究领域

化学合成、生化分析、医学成像

近期论文

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49. Qian Liu, Ting-ting Pan, Li-juan Wang,* and Chun-yang Zhang.* Mirror-synchronized asymmetric CRISPR nanoswitch for single-molecule profiling of multiple circRNAs in different stages of breast cancer. Nucleic Acids Research, 2025, doi:10.1093/nar/gkaf1123. (IF:13.1) (JCR一区) 48. Qian Han, Shi Wang, Li-juan Wang,* and Chun-yang Zhang.* Shattering kinetic constraints: hierarchically activatable DNAzyme nanoantennas for in situ mRNA imaging and precise cancer theranostics. Biosensors and Bioelectronics, 2026, 291, 118016. (IF:10.5) (JCR一区) 47. Wen-jing Liu, Junzhi Liu, Li-juan Wang,* Chun-yang Zhang,* Wei Gao.* “Repaired and activated” DNAzyme-RCA circuit enables one-pot and label-free detection of O6-Methylguanine DNA methyltransferase in clinical tissues. Analytical Chemistry, 2025, 97(41): 22977–22985. (IF: 6.7) (JCR一区) (Nature Index) 46. Jie Gao, Qian Han, Hao Liu, Ming-li Luo, Li-juan Wang,* Chun-yang Zhang.* Multicyclic ligation-driven self-assembly of magnetic nanobundles for sensitive profiling of multiple repair glycosylases in cancer cells. Analytical Chemistry, 2025, 97(35): 19369–19379. (IF: 6.7) (JCR一区) (Nature Index) 45. Huimin Yuan, Hai-juan Li, Li-juan Wang,* and Chun-yang Zhang.* Tumor microenvironment-responsive dynamic self-assembly of DNAzyme nanowires for high-contrast imaging of multiple messenger RNAs and chemotherapy. Biosensors and Bioelectronics, 2025, 287, 117728. (IF: 10.7) (JCR一区) 44. Huimin Yuan, Bao-mei Zhou, Wei Gao,* Li-juan Wang,* and Chun-yang Zhang.* Endogenous ATP-driven self-dissociated DNA nanoflowers for rapid imaging of multiple long noncoding RNAs and chemotherapy. Chemical Engineering Journal, 2025, 518, 164594. (IF: 13.4) (JCR一区) 43. Qian Liu, Bao-mei Zhou, Li-juan Wang,* and Chun-yang Zhang.* Construction of a hierarchical DNA circuit for single-molecule profiling of locus-specific N6-methyladenosine-MALAT1 in clinical tissues. Biosensors and Bioelectronics, 2025, 274, 117198. (IF: 10.7) (JCR一区) 42. Yao Jiang, Tao Wang, Li-xue Qiao, Li-juan Wang,* and Chun-yang Zhang.* Construction of an end-repairing-engineered quadratic in vitro transcription machine for single-molecule monitoring of alkaline phosphatase in human cancers. Talanta, 2025, 283, 127104. (IF: 5.6) (JCR一区) 41. Shi Wang, Hao Liu, Qinfeng Xu, Li-juan Wang,* and Chun-yang Zhang.* Selective non-Watson-Crick pairing-guided DNA synthesis for locus-specific analysis of 8-oxo-7,8-dihydroguanine in telomeres at ultrahigh resolution. Sensors and Actuators B: Chemical, 2024, 417, 136122. (IF: 8.4) (JCR一区) 40. Li-juan Wang, Wen-jing Liu, Lu-yao Wang, Yun Han, Dong-ling Li, and Chun-yang Zhang.* Construction of an enzymatically controlled DNA nanomachine for one-step imaging of telomerase in living cells. Analytical Chemistry, 2024, 96(11): 4647-4656. (IF: 7.4) (JCR一区) (Nature Index) 39. Li-juan Wang, Qian Liu, Ying-ying Lu, LeLiang, and Chun-yang Zhang.* Silver-coordinated Watson-Crick pairing-driven three-dimensional DNA walkers for selective detection of genomic N6‑methyladenine and N4‑methylcytosineat single-molecule level. Analytical Chemistry, 2024, 96(5): 2191-2198. (IF: 7.4) (JCR一区) (Nature Index) 38. Li-juan Wang, Xiao-wen Liu, Xinyi Zhang,Yun Han, Qian Liu, Zi-yue Wang,* and Chun-yang Zhang.* Construction of a multiple ligation-driven exponentially symmetric T7-transcription machinery for single-molecule monitoring of diverse single-nucleotide polymorphisms in human cancers. Chemical Engineering Journal, 2024, 158, 148251. (IF: 15.1) (JCR一区) 37. Wen-jing Liu, Li-juan Wang*, and Chun-yang Zhang.* Progress in quantum dot based biosensors for microRNA assay: A review. Analytica Chimica Acta, 2023, 1278, 341615. (IF: 6.2) (JCR一区) 36. Li-juan Wang, Qian Liu, Fei Ma,* and Chun-yang Zhang.* Target-responsive DNAzyme probes for luminescence detection and imaging of DNA-modifying enzymes. TrAC Trends in Analytical Chemistry, 2023, 167, 117270. (IF: 13.1) (JCR一区) 35. Huimin Yuan, Shi Wang, Li-juan Wang*, and Chun-yang Zhang.* A CpG methylation-powered dynamic three-dimensional-DNAzyme walker for single-molecule monitoring of multiple cytosine-C5 methyltransferases. Sensors and Actuators B: Chemical, 2023, 390, 133959. (IF: 9.221) (JCR一区) 34. Meng Liu, Nan Zhong, Xiaorui Tian, Li-juan Wang*, and Chun-yang Zhang.* Programmable strand displacement-driven assembly of single quantum-dot nanosensor for accurate monitoring of human SMUG1 uracil-DNA glycosylase at the single-cell level. Sensors and Actuators B: Chemical, 2023, 382,133568. (IF: 9.221) (JCR一区) 33. Li-juan Wang, Meng-meng Lv, Jin-ping Hu, Meng Liu, and Chun-yang Zhang.* Proximity ligation-transcription circuits-powered exponential amplifications for single-molecule monitoring of telomerase in human cells. Chemical Communications, 2023, 59(9): 1181-1184. (IF: 6.065) (JCR二区) (Nature Index) 32. Meng Liu, Di Zhang, Jin-ping Hu, Li-juan Wang,* Jian-Ge Qiu* and Chun-yang Zhang.* Construction of bidirectional strand displacement-driven three-dimensional DNA walkers for single-molecule monitoring of multiple DNA glycosylases. Sensors and Actuators B: Chemical, 2023, 380, 133357. (IF: 9.221) (JCR一区) 31. Li-juan Wang, Li-ping Pan, Xiaoran Zou, Jian-Ge Qiu,* and Chun-yang Zhang.* Activatable self-dissociating of Watson-Crick structures with fluorescent nucleotides for multiple human glycosylases sensing at the single-cell level. Analytical Chemistry, 2022, 94(50): 17700-17708. (IF: 8.008) (JCR一区) (Nature Index) 30. Li-juan Wang, Qian Han, Jin-ping Hu, Hou-xiu Wang, and Chun-yang Zhang.* Structure-switchable hairpins-powered exponential replications for sensing attomolar microRNA single nucleotide polymorphisms in human cancer tissues with zero background. Analytical Chemistry, 2022, 94(44): 15171-15175. (IF: 8.008) (JCR一区) (Nature Index) 29. Li-juan Wang, Hao Liu, Xiao-Fang Li, Yingying Meng, Jian-Ge Qiu,* and Chun-yang Zhang.* Methylation-powered engineering of a dual-color light-up RNA nanosensor for label-free and ultrasensitive sensing of multiple DNA methyltransferases. Sensors and Actuators B: Chemical, 2022, 371, 132524. (IF: 9.221) (JCR一区) 28. Ming-hao Liu, Wan-tong Yu,Meng Liu, Yan Zhang, Li-juan Wang,* and Chun-yang Zhang.* Enzymatic DNA repair cascade-driven fluorophore encoding for sensitively sensing telomerase activity in cancer cells. Sensors and Actuators B: Chemical, 2022, 359(15): 131603. (IF: 9.221) (JCR一区) 27. Li-juan Wang, Qian Han, Jian-Ge Qiu, and Chun-yang Zhang.* Cooperative in-situ assembly of G-quadruplex DNAzyme nanowires for one-step sensing of CpG methylation in human genomes. Nano Letters, 2022, 22(1): 347-354. (IF: 12.262) (JCR一区) 26. Li-juan Wang, Hao Liu, Xiaoran Zou, Qinfeng Xu, and Chun-yang Zhang.* 3'-Terminal repair-powered dendritic nanoassembly of poly-adenine molecular beacons for one-step quantification of alkaline phosphatase in human serum. Analytical Chemistry, 2021, 93(30):10704-10711. (IF: 8.008)(JCR一区) (Nature Index) 25. Li-juan Wang, Le Liang, Jian-Ge Qiu, BingHua Jiang,* and Chun-yang Zhang.* A controlled T7 transcription-driven symmetric amplification cascade machinery for single-molecule detection of multiple repair glycosylases. Chemical Science, 2021, 12(15):5544-5554. (IF: 9.969) (JCR一区) (Nature Index) 24. Yueying Li, Shuli Sun, Xiaorui Tian, Jian-Ge Qiu, BingHua Jiang, Li-juan Wang,* and Chun-yang Zhang.* Dephosphorylation-directed tricyclic DNA amplification cascades for specific and sensitive detection of protein tyrosine phosphatase. Chemical Communications, 2020, 56(78): 11581-11584. (IF: 6.065) (JCR二区) (Nature Index) (Cover article) 23. Li-juan Wang, Xiao Han, Jian-Ge Qiu, BingHua Jiang,* and Chun-yang Zhang.* Cytosine-5 methylation-directed construction of Au nanoparticle-based nanosensor for simultaneous detection of multiple DNA methyltransferases at the single-molecule level. Chemical Science, 2020, 11(35): 9675-9684. (IF: 9.969) (JCR一区) (Nature Index) 22. Li-juan Wang, Ming Ren, Hou-xiu Wang,Jian-Ge Qiu, BingHua Jiang,* and Chun-yang Zhang.* Construction of a quencher-free cascade amplification system for highly specific and sensitive detection of serum circulating miRNAs. Analytical Chemistry, 2020, 92(12): 8546-8552. (IF: 8.008) (JCR一区) (Nature Index) 21. Li-juan Wang, Ying-ying Lu, and Chun-yang Zhang.* Construction of self-directed replication system for label-free and real-time sensing of repair glycosylases with zero background. Chemical Science, 2020, 11(2), 587-595. (IF: 9.969) (JCR一区) (Nature Index) 20. Chen-chen Li, Zi-yue Wang, Li-juan Wang*, and Chun-yang Zhang.* Biosensors for epigenetic biomarkers detection: a review. Biosensors and Bioelectronics, 2019, 144, 111695-111705. (IF: 12.545) (JCR一区) 19. Li-juan Wang, Ming-li Luo, Xiao-yun Yang, Xiao-fang Li, Yanxia Wu, and Chun-yang Zhang.* Controllable autocatalytic cleavage-mediated fluorescence recovery for homogeneous sensing of alkyladenine DNA glycosylase from human cancer cells. Theranostics, 2019, 9(15): 4450-4460. (IF: 11.6) (JCR一区) 18. Huige Zhang, Li-juan Wang, Lili Wang, Hongli Chen,* Xingguo Chen, and Chun-yang Zhang.* Development of cascade isothermal amplification approach for sensitive detection of DNA methyltransferase. Journal of Materials Chemistry B, 2019, 7(1): 157-162. (IF: 7.571) (JCR一区) (co-first author) 17. Li-juan Wang, Hou-xiu Wang, Longhe Jiang, and Chun-yang Zhang.* Development of an in vitro autocatalytic self-replication system for biosensing application. ACS Sensors, 2018, 3 (12): 2675-2683. (IF: 9.618) (JCR一区) 16. Li-juan Wang, Zi-yue Wang, and Chun-yang Zhang.* Primer dephosphorylation-initiated circular exponential amplification for ultrasensitive detection of alkaline phosphatase. Analyst, 2018, 143(19): 4606-4613. (IF: 5.227) (JCR一区) (Hot paper) 15. Li-juan Wang, Xiao Han, Chen-chen Li, and Chun-yang Zhang.* Single-ribonucleotide repair-mediated ligation-dependent cycling signal amplification for sensitive and specific detection of DNA methyltransferase. Chemical Science, 2018, 9(28): 6053-6061. (IF: 9.969) (JCR一区) (Nature Index) (Cover article) 14. Li-juan Wang, Ming Ren, Li Liang, and Chun-yang Zhang.* Controllable fabrication of bio-bar codes for dendritically amplified sensing of human T-lymphotropic virus. Chemical Science, 2018, 9(22): 4942-4949. (IF: 9.969) (JCR一区) (Nature Index) (Cover article) 13. Zi-yue Wang, Li-juan Wang, Qianyi Zhang, Bo Tang,* and Chun-yang Zhang.* Single quantum dot-based nanosensor for sensitive detection of 5-methylcytosine at both CpG and non-CpG sites. Chemical Science, 2018, 9(5): 1330-1338. (IF: 9.969) (JCR一区) (Nature Index) (co-first author) 12. Li-juan Wang, Ming-li Luo, Qianyi Zhang, Bo Tang,* and Chun-yang Zhang.* Single quantum dot-based nanosensor for rapid and sensitive detection of terminal deoxynucleotidyl transferase. Chemical Communications, 2017, 53(80): 11016-11019. (IF:6.065) (JCR二区) (Nature Index) 11. Li-juan Wang, Qianyi Zhang, Bo Tang,* and Chun-yang Zhang.* Single-molecule detection of polynucleotides kinase based on phosphorylation-directed recovery of fluorescence quenched by Au nanoparticles. Analytical Chemistry, 2017, 89(13): 7255-7261. (IF: 8.008) (JCR一区) (Nature Index) 10. Li-juan Wang, Ming Ren, Qianyi Zhang, Bo Tang,* and Chun-yang Zhang.* Excision repair-initiated enzyme-assisted bicyclic cascade signal amplification for ultrasensitive detection of uracil-DNA glycosylase. Analytical Chemistry, 2017, 89(8): 4488-4494. (IF: 8.008) (JCR一区) (Nature Index) 9. Li-juan Wang, Fei Ma, Bo Tang,* and Chun-yang Zhang.* Sensing telomerase: from in vitro detection to in vivo imaging. Chemical Science, 2017, 8(4): 2495-2502. (IF: 9.969) (JCR一区) (Nature Index) 8. Li-juan Wang, Zi-yue Wang, Qianyi Zhang, Bo Tang,* and Chun-yang Zhang.* Cyclic enzymatic repairing-mediated dual-signal amplification for real-time monitoring of thymine DNA glycosylase. Chemical Communications, 2017, 27(53): 3878-3881. (IF: 6.065) (JCR二区) (Nature Index) 7. Li-juan Wang, Fei Ma, Bo Tang,* Chun-yang Zhang.* Base-excision-repair-induced construction of a single quantum-dot-based sensor for sensitive detection of DNA glycosylase activity. Analytical Chemistry, 2016, 88(15): 7523-7529. (IF: 8.008) (JCR一区) (Nature Index) 6. Li-juan Wang, Yong Yang, Chun-yang Zhang*. Phosphorylation-directed assembly of a single quantum dot based nanosensor for protein kinase assay. Analytical Chemistry, 2015, 87(9): 4696-4703. (IF: 8.008) (JCR一区) (Nature Index) 5. Li-juan Wang, Yan Zhang, Chun-yang Zhang*. A target-triggered exponential amplification-based DNAzyme biosensor for ultrasensitive detection of folate receptors. Chemical Communications, 2014, 50(97): 15393-15396. (IF: 6.065) (JCR二区) (Nature Index) 4. Yan Zhang, Li-juan Wang, Chun-yang Zhang*. Highly sensitive detection of telomerase using a telomere-triggered isothermal exponential amplification-based DNAzyme biosensor. Chemical Communications, 2014, 50(15): 1909-1911. (IF: 6.065) (JCR二区) (Nature Index) (co-first author) 3. Lijuan Wang, Fei Ma, Sheng Xu, Tianqing Zheng, Ren Wang, Huiping Chen, Wenbiao Shen*. Cloning and characterization of a heme oxygenase-2 gene from rice (Oryza sativa L.), and its expression analysis in response to some abiotic stresses. Acta Physiologiae Plantarum, 2014, 36(4): 893-902. (IF: 2.736) (JCR二区) 2. Fei Ma, Lijuan Wang, Jiale Li, Muhammad Kaleem Samma, Yanjie Xie, Ren Wang, Jin Wang, Jing Zhang, Wenbiao Shen*. Interaction between HY1 and H2O2 in auxin-induced lateral root formation in Arabidopsis, Plant Molecular Biology, 2014, 85(1-2): 49-61. (IF: 4.335) (JCR一区) (co-first author) 1. Li-juan Wang, Yan Zhang, Chun-yang Zhang*. Ultrasensitive detection of telomerase activity at the single-cell level. Analytical Chemistry, 2013, 85(23): 11509-11517. (IF: 8.008) (JCR一区) (Nature Index)

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