个人简介
James officially joined the University of Wolverhampton in September 2008 from Keele University, where he held the position of Senior Ranking Research Fellow in a multi-million Euros adventure consortium with German, Dutch, and UK partners under the support of SIXTH FRAMWORK PROGRAMME: New and emerging science and technologies (NEST)- FP6-NEST-2006-INTEFRATING Grant agreement number: 28861.
James has over 25 years experience in higher education and 4 years in a R&D institution. James has established excellent connections and a rich history of successful activities involving external academic institutions, healthcare service, and industrial/commercial organisations. In 1998, James became Project Manager in Polymer Processing Group at Singapore Institute of Manufacturing Technology, dealing with surface adhesion related industrial projects resulting one patent. James received annual achievement award in 2000 and initiated a pioneer program of 3D printing with Singapore University Hospital and Private Company in 2001. When James was at UK Centre for Tissue Engineering, a 10 million Interdisciplinary Research Collaboration (IRcol) between University of Liverpool and University of Manchester under the support of the Research Councils (BBSRC, MRC, EPSRC), James was invited on behalf of UK Centre for Tissue Engineering giving a short course on Nanoscience and Tissue Engineering, in iNanoSchool, Autumn School 2005, at Fuglsøcentret, University of Aarhus, Denmark, in 2005. Being a specialist in biomaterials, James initiated a FP7 Marie Curie IRSES exchange programme of Hyanji Scaffold at Keele University in 2008, participating in the programme as an honorary senior lecturer since 2009. In 2011, James initiated another Marie Curie FP7 IRSES exchange programme of Heptag Exchange at the University of Wolverhampton and then first FP7 Marie Curie Incoming Fellowship with colleague in 2013. James was appointed Professor in Pharmaceutics in 2014. Under James’ directorship, Cancer Targeted Delivery Initiative was formed in 2012 and joint Nanomedicine program with Keele University was activated in 2016.
James was board director of Academy of Pharmaceutical Sciences of Great Britain from 2010 to 2014. James is also a Guest Professor at Sichuan University, China Since 2008; Editorial Board for Nanoscience and Nanotechnology Letter, USA from 2008 to 2012; an honorary senior lecturer at Keele University, UK since 2009; Expert Evaluator for Horizon 2020 Marie Sklodowska-Curie Action-RISE since 2014; and Guest Editor for Materials Special Issue: Materials for Drug Delivery and Pharmaceutical Considerations in 2016~17.
James is author and co-author of over 70 publications and 3 book chapters, filed 6 patents, and delivered over 13 presentations nationally and internationally.
研究领域
1) Targeted drug delivery
Passive and active targeting approaches individually and/or combination are attempted, passive targeting aiming at particle size and pH control through vehicle design and characterisation and active targeting aiming at ligand identification and conjugation. Collaboration with oncologist for specific cancer studies involving in-vitro cancer cell and in-vivo animal models. Sampler publications can be found on Heptag Exchange website: http://heptagexchange.wlv.ac.uk/publications.php
2) Drug Formulation
Sustained release tablets are prepared by formulation of active pharmaceutical ingredient (API) with cellulose ethers. API content in tablet is quantified using HPLC or UV Vis analysis. Sustained release profile is analysed in dissolution apparatus according to British Pharmacopoeia.
3) Particulate Delivery Systems
Particulate delivery systems are prepared using emulsion method. Polycaprolactone is a typical vehicle material in forming microspheres for API encapsulation. Polyester is another vehicle material for growth factor release.
4) Nanotechnology
Amphiphilic block polymer or dendrimer are prepared and self-assembled nanoparticles are formed for passive and pH controlled targeted delivery of Doxorubicin. Sampler publications can be found on Heptag Exchange website: http://heptagexchange.wlv.ac.uk/publications.php
5) Biomaterials and tissue regeneration
Polyester encapsulated growth factor is embedded in collagen gel matrix to achieve sustained release of growth factor stimulating sustained cell and tissue regeneration. Sampler publications can be found on Hyanji Scaffold website: https://www.keele.ac.uk/hyanjiscaffold/publications/
6) Pharmaceutical materials
Pharmaceutical materials from natural and man-made resources are considered and evaluated. Hybrid materials are synthesized through grafting for targeted delivery purpose.
7) Separation and extraction
Nanomaterials and nanotechnology are incorporated in separation and extraction of active pharmaceutical ingredients in herb resources.
8) Pharmaceutical analysis
Analytical methods and protocols are set up for quality control purpose. Regulatory considerations are also introduced for quality assurance requirements
近期论文
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He Y, Zhou J, Ma S, Nie Y, Yue D, Jiang Q, Mohamed Wali AR, Tang JZ, Gu Z (2016) Multi-Responsive “Turn-On” Nanocarriers for Efficient Site-Specific Gene Delivery In Vitro and In Vivo, Advanced Healthcare Materials, 26 September 2016, DOI: 10.1002/adhm.201600710 (IF:5.790)
Pu L, Wang J, Li N, Chai Q, Irache JM, Wang G, Tang JZ, Gu Z (2016) Synthesis of Electroneutralized Amphiphilic Copolymers with Peptide Dendrons for Intramuscular Gene Delivery. ACS Applied Materials & Interface Publication date (Web): May 16, 2016 DOI: 10.1021/acsami.6b02592 (IF:6.723).
Huarte J, Espuelas S, Lai Y, He B, Tang JZ, Irache JM (2016) Oral delivery of camptothecin using cyclodextrin/poly(anhydride) nanoparticles, International Journal of Pharmaceutics, 506: 116-128 doi:10.1016/j.ijpharm.2016.04.045 (IF: 3.65)
Zhang W, Liu X, Fan H, Zhu D, Wu X, Huang X, Tang JZ (2016) Separation and purification of alkaloids from Sophora flavescens Ait. by focused microwave-assisted aqueous two-phase extraction coupled with reversed micellar extraction, Industrial Crops and Products 86: 231–238 doi:10.1016/j.indcrop.2016.03.052 (IF: 2.837)
Chen Z, Zhang W,Tang X, Fan H, Xie X, Wan Q, Wu X, Tang JZ (2016) Extraction and characterisation of polysaccharides from Semen Cassiae by microwave-assisted aqueous two-phase extraction coupled with spectroscopy and HPLC, Carbohydrate Polymers 144: 263-270 doi:10.1016/j.carbpol.2016.02.063 (IF: 4.074)
Ma S, Zhou J, Mohamed Wali AR, He Y, Xu X, Tang JZ, Gu Z (2015) Self-assembly of pH-sensitive fluorinated peptide dendron functionalized dextran nanoparticles for on-demand intracellular drug delivery. J Mater Sci: Mater Med 26(8):219 DOI 10.1007/s10856-015-5550-z (IF: 2.587)
Yang Y, Li N, Nie Y, Sheng M, Yue D, Wang G, Tang JZ, Gu Z (2015) Folate-modified poly(malic acid) graft polymeric nanoparticles for targeted delivery of doxorubicin: synthesis, characterisation and folate receptor expressed cell specificity. J Biomed Nanotech 11: 1628-1639 doi:10.1166/jbn.2015.2132 (IF: 5.338)
Chen Z, Zhang W, Wang L, Fan H, Wan Q, Wu X, Tang X, Tang JZ (2015) Enantioseparation of racemic flurbiprofen by aqueous two-phase extraction with binary chiral selectors of L-dioctyl tartrate and L-tryptophan, Chirality 27(9): 650-657. DOI: 10.1002/chir.22481 (IF: 1.886)
Zhang W, Zhu D, Fan H, Liu X, Wan Q, Wu X, Liu P, Tang JZ (2015) Simultaneous extraction and purification of alkaloids from Sophora Flavescens Ait. by microwave-assisted aqueous two-phase extraction with ethanol/ammonia sulfate system. Separation and Purification Technology 141:113-123 doi:10.1016/j.seppur.2014.11.014 (IF: 3.523)
Dong CL, Webb WR, Peng Q, Tang JZ, Forsyth NR, Chen GQ, El Haj AJ (2015) Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model. J Biomed Mater Res Part A 103A: 282-288 doi: 10.1002/jbm.a.35149. (IF: 2.840)
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