Howl, John - University of Wolverhampton - Faculty of Science & Engineering

研究领域

Many of my research efforts have addressed key questions of the molecular pharmacology of receptors and ion channels, particularly those GPCRs which bind peptide hormones and neuropeptides. More recent studies have focussed upon the development of cell penetrating peptides and bioportides. These investigations have necessarily required the development of expertise in a broad repertoire of skills within the related fields of biochemistry and molecular cell biology.

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Foreman, M.A, Gu, Y., Howl, J.D., Jones, S. & Publicover, S.J. (2005) Group III metabotropic glutamate receptor activation inhibits Ca2+ influx and nitric oxide synthase activity in bone marrow stromal cells. J. Cell. Physiol. 204, 704-713. Jones, S., Farquhar, M., Martin, A. & Howl, J. (2005) Intracellular translocation of the decapeptide carboxyl terminal of Gi3α induces the dual phosphorylation of p42/p44 MAP kinases. Biochim. Biophys. Acta. 1745, 207-214. Jones, S. & Howl, J. (2006) Biological applications of the receptor mimetic peptide mastoparan. Curr. Protein Peptide Sci. 7, 501-508. Baker, R.D., Howl, J. & Nicholl, I.D. (2007) A sychnological cell penetrating peptide mimic of p21WAF1/CIP1 is pro-apoptogenic. Peptides 28, 731-740. Jones, S., Martel,C, Belzacq-Casagrande, A, Brenner, C. & Howl, J. (2008) Mitoparan and target-selective chimeric analogues: membrane translocation and intracellular redistribution induces mitochondrial apoptosis. Biochim. Biophys. Acta. 1783, 849-863. Farquhar, M.J., Harris, H.J., Jones, S., Nielsen, S.U., Brimacombe, C.L., Molina, S., Toms, G.L., Maurel, P., Howl, J., van Ijzendoorn, S.V.D., Balfe, P. & McKeating, J.A. (2008). Protein Kinase A dependent step(s) in Hepatitis C virus entry and infectivity. J. Virol. 82, 8797-8811. Howl, J. & Jones S. (2008) Proteomimetic cell penetrating peptides. Int. J. Pept. Res. Ther. 14, 359-366. Howl, J & Jones S. (2009) Transport molecules using reverse sequence HIV-TAT polypeptides: not just any old Tat? Expert Opin. Therapeutic Patents 19, 1329-1333. Jones, S., Holm, T., Mäger, I., Langel, Ü. & Howl, J. (2010) Characterisation of bioactive cell penetrating peptides from cytochrome c: protein mimicry and the development of a novel apoptogenic agent. Chem. & Biol. 17, 735-744. Jones, S & Howl, J. (2011) Enantiomer-specific bioactivities of peptidomimetic analogues of mastoparan and mitoparan: Characterisation of inverso mastoparan as a highly efficient cell penetrating peptide. Bioconjugate Chem. 23, 47-56. Howl, J. Matou-Nasri, S., West, D.C., Farquhar, M., Slaninová, J., Östenson, C-G., Zorko, M., Östlund, P., Kumar, S., Langel, Ü., McKeating, J. & Jones, S. (2012) Bioportide: An emergent concept of bioactive cell penetrating peptide. Cell. Mol. Life Sci. 69, 2951-2966.