Heaselgrave, Wayne - University of Wolverhampton - Faculty of Science & Engineering

个人简介

Dr Wayne Heaselgrave joined the University of Wolverhampton in January 2015 after spending 2 years as a Senior Lecturer at the University Worcester and 4 years as an Honorary Lecturer in Parasitology at the University of Leicester. Dr Heaselgrave has extensive research experience in the field of contact lens disinfection and is particularly interested in the potentially blinding eye infection Acanthamoeba keratitis. Approximately 90% of cases of Acanthamoeba keratitis occur in contact lens wearers due to poor contact lens hygiene and through a failure to disinfect contact lenses properly. The lack of a licenced treatment for this infection and the resistance of Acanthamoeba to most drugs at concentration tolerated by the eye make this one of the most difficult eye infections to treat. Wayne has close links to the contact lenses industry and spends part of his time researching and developing new contact lens disinfectants and therapeutic agents to treat eye infections Previously, Dr Heaselgrave has been involved in the application of Solar Disinfection (SODIS) for the sterilisation of drinking water in countries where access to clean water is limited. Wayne has recently completed a 3.5 year European Commission (EC) funded project working in collaboration with researchers from South Africa, Switzerland, Ireland, Cambodia, Zimbabwe, Spain and Kenya investigating SODIS. As a microbiologist, Wayne’s role on the project was to test SODIS against a variety of waterborne protozoan and viral pathogens including Ascaris, Giardia, Acanthamoeba, Naegleria, Entamoeba, Cryptosporidium, coxsackievirus, poliovirus and hepatitis A virus. Full details of this project and its findings can be found on the following website: http://cordis.europa.eu/documents/documentlibrary/122807461EN6.pdf Qualifications PhD “The chemotherapy and disinfection of Acanthamoeba spp. and the role of catecholamines in mediating the encystment process” – University of Leicester (2006) MSc Applied Parasitology & Medical Entomology – Liverpool School of Tropical Medicine (2001) BSc (Hons) Pharmacology – University of Liverpool (2000)

研究领域

Development of improved contact lens disinfectants against planktonic and biofilm bacteria and other organisms Cell signalling in protozoa Solar Disinfection (SODIS) of drinking water for the inactivation of viral, protozoan and bacterial pathogens. Development of improved drug delivery systems for the treatment of protozoan infections and biofilm penetration

近期论文

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Ahmad AF, Heaselgrave W, Andrew PW, Kilvington S (2013). The In Vitro Efficacy of Antimicrobial Agents Against the Pathogenic Free-Living Amoeba Balamuthia mandrillaris. J Eukaryot Microbiol. 2013 Jun 20 Heaselgrave W, Kilvington S (2012).The efficacy of simulated solar disinfection (SODIS) against coxsackievirus, poliovirus and the hepatitis A virus. Journal of Water & Health 10(4). Heaselgrave W,Kilvington S (2011).The efficacy of simulated solar disinfection (SODIS) againstAscaris,Giardia,Acanthamoeba,Naegleria,Entamoeba andCryptosporidium.Acta Trop. Aug;119(2-3):138-43. Heaselgrave W, Kilvington S (2010). Antimicrobial activity of simulated solar disinfection against bacterial, fungal, and protozoan pathogens and its enhancement by riboflavin. Appl Environ Microbiol. Sep;76(17):6010 Heaselgrave W, Andrew PW, Kilvington S (2010). Acidified nitrite enhances hydrogen peroxide disinfection of Acanthamoeba, bacteria and fungi. J Antimicrob Chemother. Jun;65(6):1207-14. Heaselgrave W, Lonnen J, Kilvington S, Santodomingo-Rubido J, Mori O (2010). The disinfection efficacy of MeniCare soft multipurpose solution against Acanthamoeba and viruses using stand-alone biocidal and regimen testing. Eye Contact Lens. Mar;36(2):90-5. Lonnen J, Heaselgrave W, Nomachi M, Mori O, Santodomingo-Rubido J (2010). Disinfection efficacy and encystment rate of soft contact lens multipurpose solutions against Acanthamoeba. Eye Contact Lens. Jan;36(1):26-32. Kilvington S, Heaselgrave W, Lally JM, Ambrus K, Powell H (2008). Encystment of Acanthamoeba during incubation in multipurpose contact lens disinfectant solutions and experimental formulations. Eye Contact Lens. May;34(3):133-9. Heaselgrave W, Patel N, Kilvington S, Kehoe SC, McGuigan KG (2006). Solar disinfection of poliovirus and Acanthamoeba polyphaga cysts in water - a laboratory study using simulated sunlight. Lett Appl Microbiol. Aug;43(2):125-30. Hughes R, Heaselgrave W, Kilvington S (2003). Acanthamoeba polyphaga strain age and method of cyst production influence the observed efficacy of therapeutic agents and contact lens disinfectants. Antimicrob Agents Chemother. Oct;47(10):3080-4