Huen, David - University of Wolverhampton - Faculty of Science & Engineering

个人简介

David originally trained in chemical engineering, pursuing a BSc(Hons) in the subject at the University of Birmingham, followed by six years as a Technologist at the Shell Pulau Bukum refinery in Singapore. In 1986, he decided to retrain as a molecular biologist, taking an MSc in molecular biology at the University of Sussex, then a PhD in cancer studies at the University of Birmingham on Epstein-Barr virus-mediated growth transformation. He continued in EBV research on a Beit ZZM fellowship before further postdoctoral research at Cambridge where he diversified into Drosophila genetics and bioinformatics. He joined the University of Wolverhampton in 2012 and is now Senior Lecturer in Bioinformatics. He currently provides teaching in molecular biology and bioinformatics.

研究领域

Metagenomics concerns itself with the genomics populations containing significant numbers of unculturable microbes. Instead of analysing the sequences from axenic cultures, metagenomic analysis infers the constituent genomes by analysing sequences directly obtained from mixed populations. David is interested in the development and application of algorithms for metagenomic analysis. He has latterly performed an analysis of the antibiotic resistance genes present in the human microbiome and 16S analysis of stool microbiota from Canada geese (Branta canadensis). He is also interested more generally in the application of computational techniques to the analysis of biological phenomena. Currently, he has been investigating the use of machine learning to large-scale protein classification. He also has collaborations where he has supplied bioinformatics support to projects involving somatic mutation detection within tumor-normal pairs and identification of genes involved in chemotherapeutic drug resistance using the near-haploid KBM7 cell line.

近期论文

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Pangeni RP, Channathodiyil P, Huen DS, Eagles LW, Johal BK, Pasha D, Hadjistephanou N, Nevell O, Davies CL, Adewumi AI, Khanom H, Samra IS, Buzatto VC, Chandrasekaran P, Shinawi T, Dawson TP, Ashton KM, Davis C, Brodbelt AR, Jenkinson MD, Bieche I, Latif F, Darling JL, Warr TJ, Morris MR (2015) The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain. Clin Epigenetics 7:57. Russell C, Begum S, Hussain Y, Hussain M, Huen D, Rahman AS, Perrie Y, Mohammed AR (2015) Pediatric drug development of Ramipril: reformulation, in viro and in vivo evaluation. J Drug Targeting doi://10.3109/1061186X.2015.1036275 Simoni A, Siniscalchi C, Huen D, Chan YS, Russell S, Windbichler N, Crisanti A (2014) Development of Synthetic Selfish Elements Based on Modular Nucleases in Drosophila melanogaster. Nucleic Acids Res. 42:461-7472. Chan Y-S, Takeuchi R, Jarjour J, Huen DS, Stoddard BL, Russell S (2013) The design and in vivo evaluation of engineered I-OnuI-based enzymes for HEG gene drive. PLoS ONE 8(9): e74254. Chan Y-S, Huen DS, Glauert R, Whiteway E, Russell S (2013) Optimising homing endonuclease gene drive performance in a semi-refractory species: The Drosophila melanogaster experience. PLoS ONE 8(1):e54130. Chan, YS, Naujoks, DA, Huen, DS, Russell, S (2011) Insect population control by homing endonuclease-based gene drive: an evaluation in Drosophila melanogaster. Genetics 188:33-44 Huen DS, Russell, S (2010) On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence. BMC Bioinformatics 11:359. Yan J, Huen D, Morley T, Johnson G, Gubb D, Roote J, and Adler PN (2008) The multiple-wing-hairs gene encodes a novel GBD–FH3 Domain-containing protein that functions both prior to and after wing hair initiation. Genetics 180:219-228.