个人简介
胡琳，教授、博士生导师、课题组长。主要从事不对称催化合成方法学与复杂天然产物的全合成研究。2010年毕业于北京大学药学院，与中科院上海有机所联合培养，获理学博士学位，师从张礼和院士和翟宏斌教授，从事天然产物的全合成研究。随后加入美国Brandeis大学邓力教授课题组，担任博士后及研究助理工作，研究方向为不对称有机小分子催化。2016年7月至今，任职于重庆大学药学院。近5年，主持省部级以上项目6项，在Nature，J. Am. Chem. Soc.，Angew. Chem. Int. Ed.，Org. Lett.，Chem Commun.等国际主流期刊上发表论文近20篇。
研究领域
不对称催化合成
重要生理活性天然产物全合成
药物合成
近期论文
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1. Gao, M.; Zhao, Y.; Zhong, C.; Liu, P.; Yin, Q.; Hu, L.* General [4+1] Cyclization Approach to Access 2,2-Disubstituted Tetrahydrofurans Enabled by Electrophilic Bifunctional Peroxides. Org. Lett. 2019, 21, 5679
2. Zhong, C.; Yin, Q.; Zhao, Y.; Li, Q.; Hu, L.* Formal [5+1] Annulation Reactions of Dielectrophilic Peroxides: Facile Access to Functionalized Dihydropyrans. Chem. Commun. 2020, 56, 13189.
3. Gao, M.; Luo, Y.; Xu, Q.; Zhao, Y.; Gong, X.; Xia, Y.*; Hu, L.* A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles. Angew. Chem., Int. Ed. 2021, 60, 19813.
4. Xu, Q.; Li, J.; Li, X.; Hu, L.* Annulation–retro-Claisen Cascade of Bifunctional Peroxides for the Synthesis of Lactone Natural Products. Chem. Commun. 2022, 58, 274.
5. Yin, Q.; Wen, X.; Chen, Y.; Gong, X.; Hu, L.* Phase-Transfer Catalyzed Asymmetric [4+1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes. Org. Lett. 2021, 23, 7529.
6. Gao, M.; Li, Y.; Li, X.; Hu, L.* Phase-Transfer-Catalyzed Asymmetric Annulations of Alkyl Dihalides with Oxindoles: Unified Access to Chiral Spiro-Carbocyclic Oxindoles. Org. Lett. 2022, 24, 875.
7. Wu, B.; Yang, J.; Gao, M.; Hu, L.* Ring-Strain-Enabled Catalytic Asymmetric Umpolung C-O Bond-Forming Reactions of 1,2-Oxazetidines for the Synthesis of Functionalized Chiral Ethers. Org. Lett. 2020, 22, 5561.
8. Wu, B.; Chen, H.; Gao, M.; Gong, X.; Hu, L.* Synthesis of 1,3-Aminoalcohols and Spirocyclic Azetidines via Tandem Hydroxymethylation and Aminomethylation Reaction of β‑Keto Phosphonates with N‑Nosyl‑O‑(2-bromoethyl)hydroxylamine. Org. Lett. 2021, 23, 4152.
9. Wu, B.; Wen, X.; Chen, H.; Hu, L.* N-Nosyl-O-Bromoethyl Hydroxylamine Acts as a Multifunctional Formaldehyde, Formaldimine, and 1,2-Oxazetidine Surrogate for C–C and C–O Bond-Forming Reactions. Org. Chem. Front. 2021, 8, 5124.
10. Feng H.; Zhao, Y.; Liu, P.; Hu, L.* Sc(OTf)3‑Catalyzed C−C Bond-Forming Reaction of Cyclic Peroxy Ketals for the Synthesis of Highly Functionalized 1,2-Dioxene Endoperoxides. Org. Lett. 2021, 23, 1632.
11. Hu, L.; Wu, Y.; Li, Z.; Deng, L.* Catalytic Asymmetric Synthesis of Chiral γ‑Amino Ketones via Umpolung Reactions of Imines. J. Am. Chem. Soc. 2016, 138, 15817.
12. Zhang, H.#, Hu, L.#; Ma, Z.; Li, R.; Zhang, Z.; Tao, C.; Cheng, B.; Li, Y.; Wang, H.; Zhai, H.* Total Synthesis of the Diterpenoid (+)-Harringtonolide. Angew. Chem. Int. Ed. 2016, 55, 116381. (# equal contribution)
13. Wu, Y.; Hu, L.; Li, Z.; Deng, L.* Catalytic Asymmetric Umpolung Reactions of Imines. Nature, 2015, 523, 445.
14. Hu, L.; Lu, X.; Deng, L.* Catalytic Enantioselective Peroxidation of α, β-Unsaturated Aldehydes for the Asymmetric Synthesis of Biologically Important Chiral Endoperoxides. J. Am. Chem. Soc. 2015, 135, 8400.
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