Maulide, Nuno - University of Vienna - Institute of Organic Chemistry

个人简介

2018- presentAdjunct PI at CeMM Associate Editor, Organic Letters Board of Editors, Organic Syntheses 2013-present Full Professor of Organic Synthesis at the University of Vienna (AT)ERC Starting Grant holder + ERC Consolidator Grant awardee.Author Profile (Angewandte Chemie) (auf Deutsch) 2013 Habilitation (Venia Docendi) at the Ruhr-Universität Bochum (DE) 2009-2013 Max-Planck-Research Group Leader (W2/Associate Professor, non-tenure-track) at the Max-Planck Institut für Kohlenforschung (DE) 2007-2008 Postdoc at Stanford University (USA) (Prof. Barry M. Trost)Topic: "Ruthenium-catalysed bond-forming reactions" 2007 Ph.D. at the Université catholique de Louvain (BE) (Prof. István E. Markó)Topic: New bifunctional reagents for the synthesis of cyclic compounds. 2004 Master's Degree (Summa cum Laude) at the Ecole Polytechnique (FR) and Université catholique de Louvain (BE). Ranked 1st out of 22 candidates. 2003 Chemistry Degree at Instituto Superior Técnico (PT) (6-month internship at Clariant AG, Basel) 1979 born in Lisbon (PT)

研究领域

Our research in the first years of the group (2009–present) has mostly focused on unusual or "unconventional" reactivity profiles of organic compounds. We have taken particular interest in high-energy reactive intermediates that can be generated under mild conditions and subsequently lead to rearrangements, domino reaction sequences or catalytic asymmetric transformations. A broad scope of activities has resulted from these efforts, spanning a large subset of areas within organic chemistry.

近期论文

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Nicolas G.-Simonian, Philipp Spieß, Margaux Riomet, Boris Maryasin, Immo Klose, Alexander Beaton Garcia, Laurin Pollesböck, Dainis Kaldre, Uroš Todorovic, Julia Liu Minghua, Daniel Kaiser, Leticia González and Nuno Maulide*Stereodivergent Synthesis of 1,4-Dicarbonyl Compounds through Sulfonium Rearrangement: Mechanistic Investigation, Stereocontrolled Access to γ-Lactones and γ-Lactams, and Total Synthesis of Paraconic Acids Journal of the American Chemical Society 2024, Just accepted. Phillip S. Grant, Miloš Vavrík, Vincent Porte, Ricardo Meyrelles and Nuno Maulide*Remote proton elimination: C–H activation enabled by distal acidification Science 2024, 384, 815–820. Bogdan R. Brutiu, Phillip. S. Grant, Daniel Kaiser and Nuno Maulide*Stereospecific cyclization of a pseudo-C2-symmetric unsaturated diol Arkivoc 2024, 5, 202412179. Iakovos Saridakis, Margaux Riomet, Oliver J. V. Belleza, Guilhem Coussanes, Nadja K. Singer, Nina Kastner, Yi Xiao, Elliot Smith, Veronica Tona, Aurélien de la Torre, Eric F. Lopes, Pedro A. Sánchez‐Murcia, Leticia González, Harald H. Sitte and Nuno Maulide*PyrAtes: Modular Organic Salts with Large Stokes Shifts for Fluo‐rescence Microscopy Angewandte Chemie International Edition 2024, 63, e202318127. Benjamin T. Jones and Nuno Maulide*Lewis Acid‐Driven Inverse Hydride Shuttle Catalysis Angewandte Chemie International Edition 2024, Just accepted. Philipp Spieß, Jakub Brześkiewicz, Ricardo Meyrelles, David Just and Nuno Maulide*Deprotective Functionalization: A Direct Conversion of Nms‐Amides to Carboxamides Using Carboxylic Acids Angewandte Chemie International Edition 2024, 63, e202318304. Vincent Porte, Miljan N.M. Milunovic, Ulrich Knof, Thomas Leischner, Tobias Danzl, Daniel Kaiser, Tim Gruene, Michal Zalibera, Ingrid Jelemenska, Lukas Bucinsky, Sergio A. V. Jannuzzi, Serena DeBeer*, Ghenadie Novitchi, Nuno Maulide* and Vladimir B. Arion*Chemical and Redox Noninnocence of Pentane-2,4-dione Bis(S-methylisothiosemicarbazone) in Cobalt Complexes and Their Application in Wacker-Type Oxidation JACS Au 2024, 4, 1166–1183. Vincent Porte, Roberto Tinelli, Phillip S. Grant, Daniel Kaiser and Nuno Maulide*The Versatile Organic Chemistry of Sulfur (IV)ACS In Focus 2022. Bogdan R. Brutiu, Giulia Iannelli, Margaux Riomet, Daniel Kaiser and Nuno Maulide*Stereodivergent 1,3-difunctionalization of alkenes by charge relocation Nature 2024, 626, 92–97. Carlos R Goncalves, Immo Klose, Simone Placidi, Daniel Kaiser and Nuno Maulide*Sulfonium Rearrangements Enable the Direct Preparation of Sulfenyl Imidinium Salts Angewandte Chemie International Edition 2024, 63, e202316579. Manuel Schupp, Iakovos Saridakis, Daniel Kaiser and Nuno Maulide* Chemical synthesis as a discovery platform in immunosuppression and determination of mode of action Nature Synthesis 2024, 3, 162–174. Philipp Spieß, Sergio Armentia Matheu, Adriano Bauer, Guilhem Coussanes, Saad Shaaban and Nuno Maulide* Ni-Catalyzed Stereoconvergent Reductive Dimerization of Bromocyclobutenes Organic Letters 2023, 26, 355–359. David Just, Carlos R. Gonçalves, Uroš Vezonik, Daniel Kaiser and Nuno Maulide*General acid-mediated aminolactone formation using unactivated alkenes Chemical Science 2023, 14, 10806–10811. Miran Lemmerer and Nuno Maulide*Lewis Base-Assisted Arylation of Unsaturated Carbonyls Chemistry – A European Journal 2023, 29, e2023024. Philipp Spieß, Ana Sirvent, Irmgard Tiefenbrunner, Jules Sargueil, Anthony J. Fernandes, Ana Arroyo-Bondía, Ricardo Meyrelles, David Just, Alexander Prado-Roller, Saad Shaaban, Daniel Kaiser and Nuno Maulide* Nms‐Amides: An Amine Protecting Group with Unique Stability and Selectivity Chemistry – A European Journal 2023, 29, e202301312. Rafael F. A. Gomes*, Bruno M. F. Gonçalves, Késsia H. S. Andrade, Bárbara B. Sousa, Nuno Maulide, Gonçalo J. L. Bernardes* and Carlos A. M. Afonso*Unlocking the Potential of Bio-Based Nitrogen-Rich Furanic Platforms as Biomass Synthons Angewandte Chemie International Edition 2023, 62, e2023044. Minghao Feng, Anthony J. Fernandes, Ana Sirvent, Eleonora Spinozzi, Saad Shaaban and Nuno Maulide*Free Amino Group Transfer via α‐Amination of Native Carbonyls Angewandte Chemie International Edition 2023, 62, e202304990. Philipp Spieß, Saad Shaaban, Daniel Kaiser and Nuno Maulide*New Strategies for the Functionalization of Carbonyl Derivatives via α-Umpolung: From Enolates to Enolonium Ions Accounts of Chemical Research 2023, 56, 1634–1644. Minghao Feng, Anthony J. Fernandes, Ricardo Meyrelles and Nuno Maulide*Direct enantioselective α-amination of amides guided by DFT prediction of E/Z selectivity in a sulfonium intermediate Chem 2023, 9, 1538–1548. Lisa S. Knaus, Bernadette Basilico, Daniel Malzl, Maria Gerykova Bujalkova, Mateja Smogavec, Lena A. Schwarz, Sarah Gorkiewicz, Nicole Amberg, Florian M. Pauler, Christian Knittl-Frank, Marianna Tassinari, Nuno Maulide, Thomas Rülicke, Jörg Menche, Simon Hippenmeyer and Gaia Novarino*Large neutral amino acid levels tune perinatal neuronal excitability and survival Cell 2023, 186, 1950–1967. Miran Lemmerer, Ján Matyašovský, Roberto Tinelli and Nuno Maulide*α-Oxamination of Amides via Electrophilic Activation Organic Syntheses 2023, 100, 136–158. Phillip S. Grant, Ricardo Meyrelles, Oliver Gajsek, Gerhard Niederacher, Boris Maryasin and Nuno Maulide*Biomimetic Cationic Cyclopropanation Enables an Efficient Chemoenzymatic Synthesis of 6,8-Cycloeudesmanes Journal of the American Chemical Society 2023, 145, 5855–5863. Irmgard Tiefenbrunner, Bogdan R. Brutiu, Tobias Stopka and Nuno Maulide*Isothiouronium-Mediated Conversion of Carboxylic Acids to Cyanomethyl Thioesters The Journal of Organic Chemistry 2023, 88, 3941–3944. Bogdan R. Brutiu and Nuno Maulide*2-(2-Ethoxy-2-oxoethyl)-1,1,3,3-tetramethylthiouronium bromide In: Encyclopedia of Reagents for Organic Synthesis; John Wiley Sons, Ltd; 2023, pp 1–3. Minghao Feng, Roberto Tinelli, Ricardo Meyrelles, Leticia González, Boris Maryasin and Nuno Maulide*Direct Synthesis of α-Amino Acid Derivatives by Hydrative Amination of Alkynes Angewandte Chemie International Edition 2023, 62, e202212399. Minghao Feng, Anthony J. Fernandes, Ricardo Meyrelles and Nuno Maulide*Direct enantioselective α-amination of amides guided by DFT prediction of E/Z selectivity in a sulfonium intermediate Chem 2023, Just accepted. Lisa S. Knaus, Bernadette Basilico, Daniel Malzl, Maria Gerykova Bujalkova, Mateja Smogavec, Lena A. Schwarz, Sarah Gorkiewicz, Nicole Amberg, Florian M. Pauler, Christian Knittl-Frank, Marianna Tassinari, Nuno Maulide, Thomas Rülicke, Jörg Menche, Simon Hippenmeyer and Gaia Novarino* Large neutral amino acid levels tune perinatal neuronal excitability and survival Cell 2023, Just accepted. Miran Lemmerer, Ján Matyašovský, Roberto Tinelli and Nuno Maulide*α-Oxamination of Amides via Electrophilic Activation Organic Syntheses 2023, 100, 136–158. Phillip S. Grant, Ricardo Meyrelles, Oliver Gajsek, Gerhard Niederacher, Boris Maryasin and Nuno Maulide*Biomimetic Cationic Cyclopropanation Enables an Efficient Chemoenzymatic Synthesis of 6,8-Cycloeudesmanes Journal of the American Chemical Society 2023, 145, 5855–5863. Irmgard Tiefenbrunner, Bogdan R. Brutiu, Tobias Stopka and Nuno Maulide*Isothiouronium-Mediated Conversion of Carboxylic Acids to Cyanomethyl Thioesters The Journal of Organic Chemistry 2023, 88, 3941–3944. Bogdan R. Brutiu and Nuno Maulide*2-(2-Ethoxy-2-oxoethyl)-1,1,3,3-tetramethylthiouronium bromide In: Encyclopedia of Reagents for Organic Synthesis; John Wiley Sons, Ltd; 2023, pp 1–3. Minghao Feng, Roberto Tinelli, Ricardo Meyrelles, Leticia González, Boris Maryasin and Nuno Maulide*Direct Synthesis of α-Amino Acid Derivatives by Hydrative Amination of Alkynes Angewandte Chemie International Edition 2023, 62 (1), e202212399. Mark A. Maskeri, Anthony J. Fernandes, Giovanni Di Mauro, Nuno Maulide* and K. N. Houk*Taming Keteniminium Reactivity by Steering Reaction Pathways: Computational Predictions and Experimental Validations Journal of the American Chemical Society 2022, 144 (51), 23358–23367. Miran Lemmerer, Manuel Schupp, Daniel Kaiser and Nuno Maulide*Synthetic approaches to 1,4-dicarbonyl compounds Nature Synthesis 2022, 1 (12), 923–935. Minghao Feng, Haoqi Zhang and Nuno Maulide*Challenges and Breakthroughs in Selective Amide Activation Angewandte Chemie International Edition 2022, 61 (49), e202212213. Miran Lemmerer, Haoqi Zhang, Anthony J. Fernandes, Tobias Fischer, Marianne Mießkes, Yi Xiao and Nuno Maulide*Synthesis of α-Aryl Acrylamides via Lewis-Base-Mediated Aryl/Hydrogen Exchange Angewandte Chemie International Edition 2022, 61 (40), e202207475. Angewandte Chemie 2022, 134 (40), e202207475. Immo Klose, Giovanni Di Mauro, Dainis Kaldre and Nuno Maulide* Inverse hydride shuttle catalysis enables the stereoselective one-step synthesis of complex frameworks Nature Chemistry 2022, 14 (11), 1306–1310. Anja Lembens*, Gerda Heinzle, Alexandra Tepla, Nuno Maulide, Alexander Preinfalk, Daniel Kaiser and Philipp Spitzer SpottingScience – a digital learning environment to introduce Green Chemistry to secondary students and the public Chemistry Teacher International 2022, 4 (2), 143–154. Minghao Feng, Ivan Mosiagin, Daniel Kaiser, Boris Maryasin and Nuno Maulide*Deployment of Sulfinimines in Charge-Accelerated Sulfonium Rearrangement Enables a Surrogate Asymmetric Mannich Reaction Journal of the American Chemical Society 2022, 144 (29), 13044–13049. Jérémy Merad, Phillip S. Grant, Tobias Stopka, Juliette Sabbatani, Ricardo Meyrelles, Alexander Preinfalk, Ján Matyasovsky, Boris Maryasin, Leticia González and Nuno Maulide*Direct Stereodivergent Olefination of Carbonyl Compounds with Sulfur Ylides Journal of the American Chemical Society 2022, 144 (27), 12536–12543. Che-Sheng Hsu, Carlos R. Gonçalves, Veronica Tona, Amandine Pons, Marcel Kaiser and Nuno Maulide*Leveraging Electron-Deficient Iminium Intermediates in a General Synthesis of Valuable Amines Angewandte Chemie International Edition 2022, 61 (20), e202115435. Angewandte Chemie 2022, 134 (20), e202115435. Miran Lemmerer, Margaux Riomet, Ricardo Meyrelles, Boris Maryasin, Leticia Gonzalez and Nuno Maulide*HFIP Mediates a Direct C-C Coupling between Michael Acceptors and Eschenmosersalt Angewandte Chemie International Edition 2022, 61 (11), e202109933. Angewandte Chemie 2022, 134 (11), e202109933. Miryam Pastor, Marie Vayer, Harald Weinstabl and Nuno Maulide*Electrochemical Umpolung C–H Functionalization of Oxindoles The Journal of Organic Chemistry 2021, 87 (1), 606–612. Marie Vayer, Miryam Pastor, Christiane Kofink and Nuno Maulide*Electrochemical Rearrangement of 3-Hydroxyoxindoles into Benzoxazinones Organic Letters 2021, 24 (1), 27–32. Ivan Mosiagin*, Katharina Pallitsch*, Immo Klose, Alexander Preinfalk and Nuno Maulide As Similar As Possible, As Different As Necessary — On-Site Laboratory Teaching during the COVID-19 Pandemic Journal of Chemical Education 2021, 98 (10), 3143–3152. Sebastian Heindl, Margaux Riomet, Ján Matyasovsky, Miran Lemmerer, Nicolas Malzer and Nuno Maulide* Chemoselective γ-Oxidation of β,γ-Unsaturated Amides with TEMPO Angewandte Chemie International Edition 2021, 60 (35), 19123–19127. Angewandte Chemie 2021, 133 (35), 19271–19275. Philipp Spieß, Martin Berger, Daniel Kaiser and Nuno Maulide*Direct Synthesis of Enamides via Electrophilic Activation of Amides Journal of the American Chemical Society 2021, 143 (28), 10524–10529. Jeremy Merad, Ján Matyasovský, Tobias Stopka, Bogdan R. Brutiu, Alexandre Pinto, Martina Drescher and Nuno Maulide*Stable and easily available sulfide surrogates allow a stereoselective activation of alcohols Chemical Science 2021, 12 (22), 7770–7774. Vincent Porte, Haoqi Zhang, Daniel Kaiser and Nuno Maulide*Harnessing ynamide activation to access deuterated carbonyls Tetrahedron 2021, 90, 132211. Hsiang-Yu Chuang, Manuel Schupp, Ricardo Meyrelles, Boris Maryasin* and Nuno Maulide*Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols Angewandte Chemie International Edition 2021, 60 (25), 13778–13782. Angewandte Chemie 2021, 133 (25), 13896–13901. Uroš Todorović, Immo Klose and Nuno Maulide*Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides Organic Letters 2021, 23 (7), 2510–2513. Bruna S. Martins, Daniel Kaiser, Adriano Bauer, Irmgard Tiefenbrunner and Nuno Maulide*Formal Enone α-Arylation via I(III)-Mediated Aryl Migration/Elimination Organic Letters 2021, 23 (6), 2094–2098. Adriano Bauer and Nuno Maulide*Recent discoveries on the structure of iodine(III) reagents and their use in cross-nucleophile coupling Chemical Science 2021, 12 (3), 853–864. Vincent Porte, Giovanni Di Mauro, Manuel Schupp, Daniel Kaiser and Nuno Maulide* Chemoselective Alpha-Deuteration of Amides Via Retro-ene Reaction Chemistry – A European Journal 2020, 26 (67), 15509–15512. Iakovos Saridakis, Daniel Kaiser and Nuno Maulide*Unconventional Macrocylizations in Natural Product SynthesisACS Central Science 2020, 6 (11), 1869–1889. Adriano Bauer, Giovanni Di Mauro, Jing Li and Nuno Maulide*An α−cyclopropanation of carbonyl derivatives by oxidative Umpolung Angewandte Chemie International Edition 2020, 59 (41), 18208–18212. Tobias Stopka, Sebastian Schröder, Nuno Maulide and Meike Niggemann*The unusual migratory aptitude in a case of α-carbonyl cation-driven 1,2-migration Tetrahedron 2020, 76 (51), 131460. Nigel S. Simpkins, Frederick E. Nytko, Philip DeShong, Marie Vayer and Nuno Maulide*Tetrabutylammonium Difluorotriphenylsilicate (TBAT) Encyclopedia of Reagents for Organic Synthesis 2020, 1–14. Vincent Porte, Daniel Kaiser and Nuno Maulide*Reductive Iodonium: Teaching an Old Claisen New Tricks Trends in Chemistry 2020, 2 (7), 589–592. Adriano Bauer, Eszter Borsos and Nuno Maulide*A Novel Class of 7-Membered Heterocyclic Compounds European Journal of Organic Chemistry 2020, 2020 (26), 3971–3974. Martin Berger, Christian Knittl-Frank, Sophie Bauer, Georg Winter and Nuno Maulide*Application of Relay C-H Oxidation Logic to Polyhydroxylated Oleanane Triterpenoids Chem 2020, 6 (5), 1183–1189. Bogdan R. Brutiu, Immo Klose and Nuno Maulide*Facile C–S Bond Cleavage of Aryl Sulfoxides Promoted by Brønsted Acid Synlett 2020, Just Accepted. Christian Knittl-Frank, Iakovos Saridakis, Thomas Stephens, Rafael Gomes, James Neuhaus, Antonio Misale, Rik Oost, Alberto Oppedisano and Nuno Maulide*Gold-Catalyzed Cycloisomerization of Sulfur Ylides to Dihydrobenzothiepines Chemistry - A European Journal 2020, 26 (48), 10972–10975. Haoqi Zhang, Margaux Riomet, Alexander Roller and Nuno Maulide*Synthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization Organic Letters 2020, 22 (6), 2376–2380. Wojciech Zawodny, Christpher J. Teskey, Magdalena Mishevska, Martin Völkl, Boris Maryasin, Leticia González and Nuno Maulide*α-Functionalisation of ketones through metal-free electrophilic activation Angewandte Chemie International Edition 2020, 59 (47), 20935–20939. Eva-Maria Zangerl-Plessl, Martin Berger, Martina Drescher, Yong Chen, Wei Wu, Nuno Maulide, Michael Sanguinetti and Anna Stary-Weinzinger*Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574 Journal of Chemical Information and Modeling 2020, 60 (1), 360–371.