Bedford, Mark - University of Texas MD Anderson Cancer Center - Department of Epigenetics and Molecular Carcinogenesis

个人简介

Degree-Granting Education 1996 Weizmann Institute of Science, ISR, PHD, Developmental Biology 1989 University of Stellenbosch, RSA, MS, Medical Biochemistry 1986 University of Stellenbosch, RSA, BS, Honors in Biochemistry 1985 University of Stellenbosch, RSA, BS Postgraduate Training 1996-2000 Postdoctoral Fellowship, Harvard Medical School, Boston, MA

研究领域

Dr. Bedford’s laboratory focuses on two research topics: 1) elucidating the biological role of arginine methylation – an abundant modification that has been implicated in signal transduction, transcriptional control and DNA repair, and 2) developing a protein domain microarray platform to interrogate the role of posttranslational modifications in driving protein-protein interactions in signal transduction. They have generated targeted disruptions and gain-of-function mouse models for these arginine methyltransferase enzymes, with a primary focus on CARM1. Using their protein-domain microarray platform, they have identified and characterized novel protein interactions; they have used these arrays to “read” the histone code. They have identified a number of novel proteins that interact with lysine and arginine methylated motifs, as well as with small molecules that can compete with these interactions. Recently, the Bedford lab expanded their array platform to include all the human phospho-reader domains, acetyl-reader domains, and most of the human PDZ domains and ubiquitin-binding domains.

近期论文

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Espejo AB, Gao G, Black K, Gayatri S, Veland N, Kim J, Chen T, Sudol M, Walker C, Bedford MT PRMT5 C-terminal phosphorylation modulates a 14-3-3/PDZ interaction switch J Biol Chem 292 (6) :2255-65, 2017 Gao G, Dhar S, Bedford MT PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1 Nucleic Acids Res 45 (8) :4359-69, 2017. e-Pub 2017 Shanle EK, Shinsky SA, Bridgers JB, Bae N, Sagum C, Krajewski K, Rothbart SB, Bedford MT*, Strahl BD* (*Corresponding authors) Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions Epigenetics Chromatin 10:12, 2017 Bae N, Viviano M, Su X, Lv J, Cheng D, Sagum C, Castellano S, Bai X, Johnson C, Khalil MI, Shen J, Chen K, Li H, Sbardella G, Bedford MT Developing Spindlin 1 small-molecule inhibitors by using protein microarrays Nat Chem Biol 13 (7) :750-756, 2017. e-Pub 2017 Zhang X, Peng D, Xi Y, Yuan C, Sagum CA, Klein BJ, Tanaka K, Wen H, Kutateladze TG, Li W, Bedford MT, Shi X G9a-mediated methylation of ERalpha links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression Nat Commun 7:10810, 2016 Gayatri S, Cowles MW, Vemulapalli V, Cheng D, Sun ZW, Bedford MT Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs Sci Rep 6:28718, 2016 Park IY, Powell RT, Tripathi DN, Dere R, Ho TH, Blasius TL, Chiang YC, Davis IJ, Fahey CC, Hacker KE, Verhey KJ, Bedford MT, Jonasch E, Rathmell WK, Walker CL Dual chromatin and cytoskeletal remodeling by SETD2 Cell 166 (4) :950-62, 2016 Yang Y, Hadjikyriacou A, Xia Z, Gayatri S, Kim D, Zurita-Lopez C, Kelly R, Guo A, Li W, Clarke SG, Bedford MT PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145 Nat Commun 6:6428, 2015 Yang Y, McBride KM, Hensley S, Lu Y, Chedin F, Bedford MT Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation Mol Cell 53 (3) :484-97, 2014 Di Lorenzo A, Yang Y, Macaluso M, Bedford MT A gain-of-function mouse model identifies PRMT6 as a NF-kB coactivator Nucleic Acids Res 42 (13) :8297-309, 2014