Chi, Robin Yonggui - Nanyang Technological University - Division of Chemistry and Biological Chemistry

个人简介

May 2007 PhD.Department of Chemistry, University of Wisconsin, Madison, USA (Under the guidance of Prof. Samuel H. Gellman) May 2002 BSc 1st Honor (highest cumulative GPA award) Department of Chemistry, Hong Kong Baptist University, Hong Kong, China (Transferred student from Tsinghua University under scholarship) Recent Recognitions: 2017 Chemical Society of Japan (CSJ) Lectureship 2016 Aldrich-Yale Lectureship 2016 Nanyang Research Award (Yong Investigator) 2015 NRF Investigatorship Award 2013 Singapore Young Scientist Award 2012 Thieme Chemistry Journal Award 2012 NTU SPMS Teaching Excellence Award 2011, 2012, 2013 ACP Lectureship Awards 2010 GSK-EDB Award on Manufacturing 2009 Singapore NRF Fellowship

研究领域

Develop state-of-art original activation and reaction modes enabled by N-heterocyclic carbene as key catalyst, design new synthetic strategies for rapid access to functional molecules; advance fundamental knowledge on catalysis and chemical synthesis. (science-driven research) Create bioactive molecules for medicinal and agricultural applications; develop green synthesis and advanced manufacturing processes. (user-inspired research)

近期论文

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Benpeng Li, Junyuan Hu, Minghong Liao, Qin Xiong, Yaqi Zhang, Yonggui Robin Chi, Xinglong Zhang,* and Xingxing Wu*. Catalyst Control over S(IV)-stereogenicity via Carbene-derived Sulfinyl Azolium Intermediates. J. Am. Chem. Soc. 2024, DOI: 10.1021/jacs.4c10486. Donghan Liu, Ting Tu, Tinglei Zhang, Guihua Nie, TianhuiLiao, Shi-Chao Ren*, Xionglong Zhang*, Yonggui RobinChi*. Photocatalytic Direct para-selective C-H Amination of BenzylAlcohols: Selectivity Independent of Side Substituents. Angew. Chem. Int. Ed. 2024, e202407293. Qian Liu, Kunpeng Teng, Yi Zhang, Ya Lv, Yonggui Robin Chi, Zhichao Jin*. Chemodivergent Parallel Kinetic Resolution of Paracyclophanes: Enantiomer Fishing with Different Substrates. Angew. Chem. Int. Ed. 2024, e202406386. Fang-Xin Wang*, Ying-Tao Chen , Hui Liu , Hengshan Wang , Hong Liang , Zhen-Feng Chen , Yonggui Robin Chi*. Total Synthesis of (‒)-Deglycocadambine. Org. Chem. Front. 2024, DOI: 10.1039/D4QO01122H. Xiang-Yu Ye , Yongtao Xie , Yonggui Robin Chi*. Frontiers of NHC catalysis: radical and site-selective reactions. Trends Chem. 2024, DOI:10.1016/j.trechm.2024.06.005. Bingbing Dong, Fengqian Zhao, Wen-Xin Lv, Ying-Guo Liu, Donghui Wei*, Junliang Wu*, Yonggui Robin Chi*. Regio- and stereoselective access to highly substituted vinylphosphine oxides via metal-free electrophilic phosphonoiodination of alkynes. Nature Commun. 2024, 15, 5385. Fengfei Lu, Fen Su, Shijie Pan, Xiuli Wu, Xingxing Wu*, Yonggui Robin Chi*. N-Heterocyclic carbene enabled functionalization of inert C(sp3)-H bonds via hydrogen atom transfer (HAT) processes. Chem. Eur. J. 2024, e202401811. Wei Wang, Xiaolin Peng, Xiaoyan Yang, Yonggui Robin Chi*, Gefei Hao*. Unveiling the dual activation effect of NHC-catalyst in an asymmetric reaction system. Org. Chem. Front. 2024, DOI: 10.1039/d4qo00660g. Xiaoqun Yang, Shichun Jiang, Meng Zhang, Tingting Li, Zhichao Jin, Xingxing Wu*, Yonggui Robin Chi*. Discovery of novel piperidine-containing thymol derivatives as potent antifungal agents for crop protection. Pest Manag Sci. 2024, DOI: 10.1002/ps.8203. Zhongfu Luo, Minghong Liao, Wei Li, Sha Zhao, Kun Tang, Pengcheng Zheng, Yonggui Robin Chi, Xinglong Zhang*, Xingxing Wu*. Ionic Hydrogen Bond-Assisted Catalytic Construction of Nitrogen Stereogenic Center via Formal Desymmetrization of Remote Diols. Angew. Chem. Int. Ed. 2024, e202404979. Rui Deng, Mingyi Pan, Jianjian Liu, Pengcheng Zheng*, Yonggui Robin Chi*. Carbene-Catalyzed Enantioselective Addition of Sulfinate to Ketones. Org. Lett. 2024, DOI: 10.1021/acs.orglett.4c01473. Youlin Deng, Hui Cai, Jiamiao Jin, Chaoyang Song, Xiao-Kang Lv, Zhichao Jin*, Yonggui Robin Chi*. Synthesis of Planar Chiral Compounds Containing-Amino Phosphonates for Anti-plant Virus Applications against Potato Virus Y. J. Agric. Food Chem. 2024, DOI:10.1021/acs.jafc.3c08686. Hui Cai, Xiaoqun Yang, Shi-Chao Ren*, Yonggui Robin Chi*. Radical Reactions with N-Heterocyclic Carbene (NHC)-Derived Acyl Azoliums for Access to Multifunctionalized Ketones. ACS Catal. 2024, 14, 8270–8293. Jinli Chen, Meng Zhang, Chunmei Yuan, Tao Zhang, Zhibing Wu, Tingting Li*, Yonggui Robin Chi*. Design, Synthesis, and Antifungal Activity of Acrylamide Derivatives Containing Trifluoromethylpyridine and Piperazine. J. Agric. Food Chem. 2024, DOI:10.1021/acs.jafc.3c09770. Liangzhen Shu, Ya Lv, Zhongyin Chen, Yixian Huang, Meng Zhang, Zhichao Jin, Tingting Li*, Yonggui Robin Chi*. Design, Synthesis and Anti-PVY Activity of Planar Chiral Thiourea Derivatives Incorporated with [2.2]Paracyclophane. Pest Manag Sci. 2024, DOI:10.1002/ps.8149. Jianjian Liu, Rui Deng, Xuyang Liang, Mali Zhou, Pengcheng Zheng*, Yonggui Robin Chi*, Carbene-catalyzed and Pnictogen Bond-assisted Access to PIII-Stereogenic Compounds. Angew. Chem. Int. Ed. 2024, e202404477. Meng Zhang, Hui Cai, Chen Pang, Zhongyin Chen, Dan Ling, Zhichao Jin,* Yonggui Robin Chi*. Design, Synthesis, and Herbicidal Evaluation of PyrrolidinoneContaining 2‑Phenylpyridine Derivatives as Novel Protoporphyrinogen Oxidase Inhibitors. J. Agric. Food Chem. 2024, 72, 10218–10226. Chaoyang Song, Chen Pang, Youlin Deng, Hui Cai, Xiuhai Gan,* Yonggui Robin Chi*. Catalytic N‑Acylation for Access to N-N Atropisomeric N‑Aminoindoles: Choice of Acylation Reagents and Mechanistic Insights. ACS Catal. 2024, 14, 6926–6935. Jiamiao Jin, Jiangtao Guo, Feng Xu, Ya Lv, Guanjie Wang, Jia Song, Wen-Xin Lv, Tingting Li*, Yonggui Robin Chi*. NHC/B(OH)3-mediated C3-selective acylation of unprotected monosaccharides: mechanistic insights and toward simpler/greener solutions. Green Chem. 2024, DOI:10.1039/D3GC05005J. Hui Cai, Xiao Zhang, Dan Ling, Meng Zhang, Chen Pang, Zhongyin Chen, Zhichao Jin, Shi-Chao Ren,* Yonggui Robin Chi*. Discovery of Pyridyl-Benzothiazol Hybrids as Novel Protoporphyrinogen Oxidase Inhibitors via Scaffold Hopping. J. Agric. Food Chem. 2024, 72, 8963–8972. Yixian Huang, Xiaolin Peng, Jinli Chen, Liangzhen Shu, Meng Zhang, Jiamiao Jin, Zhichao Jin*, Yonggui Robin Chi*. Discovery of Novel Chiral Indole Derivatives Containing the Oxazoline Moiety as Potential Antiviral Agents for Plants. J. Agric. Food Chem. 2024, 72, 6979–6987. Minghong Liao, Yonggui Liu, Hongyan Long, Qin Xiong, Xiaokang Lv, Zhongfu Luo, Xingxing Wu*, Yonggui Robin Chi*. Enantioselective sulfinylation of alcohols and amines by condensation with sulfinates. Chem 2024, DOI:10.1016/j.chempr.2024.02.016. Kunpeng Teng, Qian Liu, Meng Zhang, Hira Naz, Pengcheng Zheng, Xingxing Wu*, Yonggui Robin Chi*. Design and Enantioselective Synthesis of Chiral Pyranone Fused Indole Derivatives with Antibacterial Activities against Xanthomonas oryzae pv oryzae for Protection of Rice. J. Agric. Food Chem. 2024, 72, 4622–4629. Ya Lv, Chengli Mou, Qian Liu, Liangzhen Shu, Yuanlin Cai, Xiaokang Lv, Zhichao Jin*, Yonggui Robin Chi*. Asymmetric Synthesis of Planar Chiral Carbonitriles and Amines via Carbene-Catalyzed Kinetic Resolution. Org. Lett. 2024, 26, 1584–1588. Xiang-Yu Ye, Guanjie Wang, Zhichao Jin, Bin Yu, Junmin Zhang, Shichao Ren,* Yonggui Robin Chi*. Direct Formation of Amide-Linked C‑Glycosyl Amino Acids and Peptides via Photoredox/Nickel Dual Catalysis. J. Am. Chem. Soc. 2024, 146, 5502–5510. Xiaokang Lv, Fen Su, Hongyan Long, Fengfei Lu, Yukun Zeng, Minghong Liao, Fengrui Che, Xingxing Wu*, Yonggui Robin Chi*. Carbene organic catalytic planar enantioselective macrolactonization. Nature Commun. 2024, 15, 958. Xiaolin Peng, Yixian Huang, Wei Wang, Shiguang Li, Ge-fei Hao, Shichao Ren,* Yonggui Robin Chi*. N‑Heterocyclic Carbene-Catalyzed Remote Enantioselective C-C Bond Formation via 1,6-Addition with Formyl Enynes. ACS Catal. 2024, 14, 2127-2133. Zhongyin Chen, Hui Cai, Xiao Zhang, Meng Zhang, Ge-Fei Hao, Zhichao Jin, Shichao Ren*, Yonggui Robin Chi*. Design, Synthesis, and Herbicidal Activity of Substituted 3-(Pyridin-2-yl)Phenylamino Derivatives. J. Agric. Food Chem. 2024, 72, 2501-2511. Kun Tang, Fen Su, Shijie Pan, Fengfei Lu, Zhongfu Luo, Fengrui Che, Xingxing Wu*, Yonggui Robin Chi*. Enones from aldehydes and alkenes by carbene-catalyzed dehydrogenative couplings. Chin. Chem. Lett. 2024, DOI:10.1016/j.cclet.2024.109495. Tingwei Shen, Jiamiao Jin, Jia Song, Hira Naz, Zhichao Jin, Yonggui Robin Chi, Xingxing Wu*. Design, enantioselective synthesis, and antiviral activities against potato virus Y of axially chiral thiazine derivatives. J. Heterocycl. Chem. 2023, 1. https://doi.org/10.1002/jhet.4776. Yuanlin Cai, Ya Lv, Liangzhen Shu, Zhichao Jin, Yonggui Robin Chi, and Tingting Li*. Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction. Research 2023, 6, 0293. Hongyan Long, Sha Zhao, Chunyan Jian, Xiuli Wu, Fengfei Lu, Minghong Liao, Fengrui Che, Xingxing Wu*, and Yonggui Robin Chi*. Carbene-catalyzed Enantioselective Seleno-Michael Addition as Access to Antimicrobial Active Se-containing Heterocycles. Sci. China Chem. 2023, DOI: 10.1007/s11426-023-1909-5. Guanjie Wang, Chang Chin Ho, Zhixu Zhou, Yong-Jia Hao, Jie Lv, Jiamiao Jin, Zhichao Jin, and Yonggui Robin Chi*. Site-Selective C−O Bond Editing of Unprotected Saccharides. J. Am. Chem. Soc. 2023, DOI:10.1021/jacs.3c10963. Chengli Mou, Ya Lv, Jiamiao Jin, Huifang Chai, Tingting Li, Yonggui Robin Chi, and Zhichao Jin*. NHC-Catalyzed Reaction of Carboxylic Acids Using Allene Ketones as Substrates and Activating Reagents. Org. Lett. 2023, 25, 8706-8710. Jiamiao Jin, Shi-Chao Ren*, Yonggui Robin Chi*. Chiral boryl radical catalyzed asymmetric radical cycloisomerization. Sci. China Chem. 2023, DOI: 10.1007/s11426-023-1900-2. Shichun Jiang, Wei Wang, Chengli Mou, Juan Zou, Zhichao Jin*, Gefei Hao* & Yonggui Robin Chi*. Facile access to benzofuran derivatives through radical reactions with heteroatom-centered super-electron-donors. Nature Commun. 2023, 14, 7381. Bivas Mondal, Hang Chen, Rakesh Maiti, Hongling Wang, Hui Cai, Chengli Mou, Lin Hao, Huifang Chai*, and Yonggui Robin Chi*. Carbene-Catalyzed Direct O-Functionalization of Ketone: Atroposelective Access to Non-C2-Symmetric Binaphthyls. Org. Lett. 2023, 25, 8252–8257. Meng Zhang, Hui Cai, Dan Ling, Chen Pang, Jinming Chang, Zhichao Jin*, Yonggui Robin Chi*. Herbicidal Activity of Beflubutamid Analogues as PDS Inhibitors and SAR Analysis and Degradation Dynamics in Wheat. J. Agric. Food Chem. 2023, 71, 16972–16983. Runjiang Song, Shichao Ren*, Yonggui Robin Chi*. Carbene- and photocatalysis redefine arene acylation. Nature synth. 2023, 2, 1009-1011. Fen Su, Fengfei Lu, Kun Tang, Xiaokang Lv, Zhongfu Luo, Fengrui Che, Hongyan Long, Xingxing Wu*, Yonggui Robin Chi*. Organocatalytic C-H Functionalization of Simple Alkanes. Angew. Chem. Int. Ed. 2023, e202310072. Li-wei Liu, Zheng-hao Ding, Ganggang Ren, Guang-di Wang, Xin Pan, Guo-hai Wei, Xiang Zhou, Zhi-bing Wu, Zhi-chao Jin, Yonggui Robin Chi*, Song Yang*. Inorganic Nanoparticles–Driven Self–Assembly of natural small molecules in water for constructing multifunctional nanocapsules against plant diseases. Chem. Eng. J. 2023. 475, 146041. Hongling Wang, Xingxing Wu, Yonggui Robin Chi. Distal difunctionalization of aldehydes via the triplet state of Breslow intermediates. Chem Catal. 2022, 2, 3273–3289 Zhaowei Bao, Juan Zou, Chengli Mou, Zhichao Jin, Shi-Chao Ren, Yonggui Robin Chi. Direct Reaction of Nitroarenes and Thiols via Photodriven Oxygen Atom Transfer for Access to Sulfonamides. Org. Lett. 2022, 24, 8907–8913. Luoqiang Zhang, Mengxin Zhao, Maoping Pu, Zhaoming Ma, Jingsong Zhou, Caiyou Chen, Yun-Dong Wu, Yonggui Robin Chi, Jianrong Steve Zhou. Nickel-Catalyzed Enantioselective Reductive Conjugate Arylation and Heteroarylation via an Elementary Mechanism of 1,4-Addition. J. Am. Chem. Soc. 2022, 144, 20249-20257. Xing Yang, Liwen Wei, Yuelin Wu, Liejin Zhou, Xinglong Zhang, Yonggui Robin Chi. Atroposelective Access to 1,3-Oxazepine-Containing Bridged Biaryls via Carbene-Catalyzed Desymmetrization of Imines. Angew. Chem. Int. Ed. 2022, e202211977. Yonggui Liu, Yanyan Wang, Xingxing Wu, Yonggui Robin Chi. Exploring Molecular Complexity by N-Heterocyclic Carbene Organocatalysis: New Activation and Reaction Diversity. Chem. Rec. 2022, e202200219. Jie Lv, Zhichao Jin, Hongling Wang, Yonggui Robin Chi. N‑Heterocyclic Carbene-Mediated Carbon-Sulfur Bond-Forming Reactions. ACS Sustainable Chem. Eng. 2022, 10, 13901-13916. Hongling Wang, Yonggui Robin Chi, Xuan Huang. Enantioselective Dual Catalysis of N-Heterocyclic Carbene and Hydrogen-Bond Donor Organocatalysts. Eur. J. Org. Chem. 2022, e202200548. Jianjian Liu, Mali Zhou, Rui Deng, Pengcheng Zheng, Yonggui Robin Chi. Chalcogen Bond-guided Conformational Isomerization Enables Catalytic Dynamic Kinetic Resolution of Sulfoxides. Nature Commun. 2022, 13, 4793. Chenghao Tang, Wei Wang, Guoyong Luo, Chaoyang Song, Zhaowei Bao, Pei Li, Gefei Hao, Yonggui Robin Chi, Zhichao Jin. Carbene-Catalyzed Activation of C-Si Bonds for Chemo- and Enantioselective Cross Brook-Benzoin Reaction. Angew. Chem. Int. Ed. 2022, 61, e2022069. Mali Zhou, Jianjian Liu, Rui Deng, Qingyun Wang, Shuquan Wu, Pengcheng Zheng, and Yonggui Robin Chi*. Construction of Tetrasubstituted Silicon-Stereogenic Silanes via Conformational Isomerization and N‑Heterocyclic CarbeneCatalyzed Desymmetrization. ACS Catal. 2022, 12, 7781-7788. Tingting Li, Zhichao Jin, Yonggui Robin Chi*. N-heterocyclic carbene-catalyzed arene formation reactions. Sci. China Chem. 2022, 65, 210–223. Shi-Chao Ren, Xing Yang, Bivas Mondal, Chengli Mou, Weiyi Tian, Zhichao Jin, Yonggui Robin Chi*. Carbene and Photocatalyst-Catalyzed Decarboxylative Radical Coupling of Carboxylic Acids and Acyl Imidazoles to Form Ketones. Nature Commun. 2022, 13, 2846. Wen-Xin Lv, Hang Chen, Xinglong Zhang, Chang Chin Ho, Yingguo Liu, Shuquan Wu, Haiqi Wang, Zhichao Jin, Yonggui Robin Chi*. Programmable Selective Acylation of Saccharides Mediated by Carbene and Boronic Acid. Chem. 2022, 8, 1518-1534. Yanlin Chen, Tingting Li, Zhichao Jin, Yonggui Robin Chi*. New Axially Chiral Molecular Scaffolds with Antibacterial Activities against Xanthomonas oryzae pv. oryzae for Protection of Rice. J. Agric. Food Chem. 2022, 70, 6050−6058. Zhiguo Zheng, Ali Dai, Zhichao Jin, Yonggui Robin Chi,* and Jian Wu*. Trifluoromethylpyridine: An Important Active Fragment for the Discovery of New Pesticides. J. Agric. Food Chem. 2022, 70, 11019–11030. Rui Deng, Shuquan Wu, Chengli Mou, Jianjian Liu, Pengcheng Zheng, Xinglong Zhang, and Yonggui Robin Chi*. Carbene-Catalyzed Enantioselective Sulfonylation of Enone Aryl Aldehydes: A New Mode of Breslow Intermediate Oxidation. J. Am. Chem. Soc. 2022, 144, 5441-5449. Jia-Lei Yan, Rakesh Maiti, Shi-Chao Ren, Weiyi Tian, Tingting Li, Jun Xu, Bivas Mondal, Zhichao Jin, and Yonggui Robin Chi*. Carbene-Catalyzed Atroposelective Synthesis of Axially Chiral Styrenes. Nature Commun. 2022, 13, 84. Ya Lv, Guoyong Luo, Qian Liu, Zhichao Jin, Xinglong Zhang, and Yonggui Robin Chi*. Catalytic Atroposelective Synthesis of Axially Chiral Benzonitriles via Chirality Control during Bond Dissociation and CN Group Formation. Nature Commun. 2022, 13, 36. Xiaokang Lv, Jun Xu, Cuiyun Sun, Fen Su, Yuanlin Cai, Zhichao Jin, and Yonggui Robin Chi*. Access to Planar Chiral Ferrocenes via N‑Heterocyclic CarbeneCatalyzed Enantioselective Desymmetrization Reactions. ACS Catal. 2022, 12, 2706-2713.