Zhao, Yu - National University of Singapore - Department of Chemistry, Faculty of Science

个人简介

Yu obtained his B.S. in Chemistry from Peking University in 2002, and his Ph.D. in Organic Chemistry from Boston College in 2008 under the guidance of Prof. Marc L. Snapper and Prof. Amir H. Hoveyda. After that, he worked with Nobel laureate Prof. Richard R. Schrock at MIT as a postdoctoral associate in the field of organometallic chemistry. In 2011, Yu was awarded the prestigious NRF fellowship from singapore and joined Department of Chemistry at NUS as an assistant professor. He was promoted to associate professor with tenure in July 2017. His research program at NUS focuses on the discovery and development of efficient catalytic methodology to promote sustainable chemical synthesis as well as application to medicinal chemistry and material science. Employment Jul 2017-present Associate Professor of Chemistry, NUS Aug 2011-Jun 2017 Assistant Professor of Chemistry, NUS 2008-2011 Postdoctoral associate with Prof. Richard R. Schrock Massachusetts Institute of Technology Education 2002- 2008 Ph.D. in Chemistry with Profs. Marc L. Snapper & Amir H. Hoveyda, Boston College 1998- 2002 B.S. in Chemistry with Prof. Limin Qi, Peking University

研究领域

Research interests of our lab lie in the discovery and development of efficient, selective as well as economical catalytic methods for chemical synthesis, with an emphasis on asymmetric catalysis. Research efforts will be focused on the identification of new activation modes for the conversion of feedstock molecules to useful organic compounds, the introduction of new approaches for catalyst discovery, and understanding the reaction mechanism. Application of the new methods toward the synthesis of molecules with a complex structure and/or useful functions will serve as a testament of the efficacy of the method development. Ultimately, the goal is to provide new chemical tools to bear on contemporary problems in the applied areas such as pharmaceuticals, chemical biology and material science.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

“Direct Access to Chiral Aliphatic Amines by Catalytic Enantioconvergent Redox-Neutral Amination of Alcohols," Ng, X. Q.; Lim, C. S.; Liaw, M. W.; Quach, T. T.; Yang, B.-M.; Isoni, V.; Wu, J.* Zhao, Y.* Nat. Synth. accepted. “Iridium-Catalyzed Enantioconvergent Borrowing Hydrogen Annulation of Racemic 1,4-Diols with Amines," Liu, Y.; Diao, H.; Hong, G.; Edward, J.; Zhang, T.; Yang, G.; Yang, B.-M.;* Zhao, Y.* J. Am. Chem. Soc. accepted. “Enantioselective Access to Triaryl-2-pyrones with Monoaxial or Contiguous C-C Diaxes via Oxidative NHC Catalysis," Zhang, S.-C.; Liu, S.; Wang X.; Wang ,S.-J.; Yang, H.; Li, L.; Yang, B.; Wong, M. W.; Zhao, Y.; Lu, S.* ACS Catal. accepted. “Anion Effect in Enantioselective Oxidative NHC Catalysis: Highly Efficient Kinetic Resolution of Tertiary alcohols and Beyond," Hu, D.; Poh, S. B.; Liu, F.; Tu, Z.; Wang, X.; Lu, S.;* Zhao, Y.* Org. Chem. Front. 2023, 10, 416-421. “Economical Access to Diverse Enantiopure Tetrahydropyridines and Piperidines Enabled by Catalytic Borrowing Hydrogen," Ng, T. W.; Tao, R.; See, W. W. L.; Poh, S. B.; Zhao, Y.* Angew. Chem. Int. Ed. 2023, 62, e202212528 (N.T.W. and T.R. contributed equally). Invited article: “Co/Zn Bimetallic Catalysis Enables Enantioselective Alkynylation of Isatins and α-Ketoesters Using Terminal Alkynes," Huang, R.-Z.; Ma, Z.-C.; Huang, Y.;* Zhao, Y.* J. Org. Chem. 2022, in press. Invited review: “Enantioselective synthesis of indoles through catalytic indolization," Yang, B.-M.;* Ng, X. Q.; Zhao, Y.* Chem Catal. 2022, 2, 3048-3076. “A green access to supported cinchona alkaloid amide catalysts for heterogeneous enantioselective allylsilylation of aldehydes and process intensity evaluation in batch and flow," Ng, X. Q.; Kang, M. H.; Toh, R. W.; Isoni, V.;* Wu, J.;* Zhao, Y.* Green Synth. Catal. 2022, 3, 272-277. “Atroposelective Synthesis of 1,1’-Bipyrroles Bearing a Chiral N-N Axis: Chiral Phosphoric Acid Catalysis with Lewis Acid Induced Enantiodivergence," Gao, Y.; Wang, L.-Y.; Zhang, T.; Yang, B.-M.;* Zhao, Y.* Angew. Chem. Int. Ed. 2022, in press. “Enantioselective Cascade Annulation of α-Amino-ynones and Enals Enabled by Gold and Oxidative NHC Relay Catalysis," Jiang, J.; Wang, X.; Liu, S.; Zhang, S.; Yang, B.; Zhao, Y.; Lu, S.* Angew. Chem. Int. Ed. 2022, in press. “Experimental and Computational Studies on the Directing Ability of Chalcogenoethers in Palladium-Catalyzed Atroposelective C–H Olefination and Allylation," Liao, G.; Zhang, T.; Jin, L.; Wang B.-J.; Xu, C.-K.; Lan, Y.;* Zhao, Y.;* Shi, B.-F.* Angew. Chem. Int. Ed. 2022, in press. “Tandem Catalytic Indolization/Enantioconvergent Substitution of Alcohols by Borrowing Hydrogen to Access Tricyclic Indoles," Yang, G.; Pan, J.; Ke, Y.-M.; Liu, Y.;* Zhao, Y.* Angew. Chem. Int. Ed. 2021, 60, 20689-20694. “Redox-Enabled Direct Stereoconvergent Heteroarylation of Simple Alcohols," Liu, Y.; Tao, R.; Lin, Z.-K.; Yang, G.;* Zhao, Y.* Nat. Commun. 2021, 12, 5035. “Catalytic Diastereo- and Enantioconvergent Synthesis of Vicinal Diamines from Diols through Borrowing Hydrogen," Pan, H.-J.; Lin, Y.; Gao, T.; Lau, K. K.; Feng, W.; Yang, B.;* Zhao, Y.* Angew. Chem. Int. Ed. 2021, 60, 18599-18604 (H.J.P. and Y.L. contributed equally). "Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides," Qian, L.; Tao, L.-F.; Wang, W.-T.; Jameel, E.; Luo, Z.-H.; Zhang, T.; Zhao, Y.; Liao, J.-Y.* Org. Lett. 2021, 23, 5086-5091. “Stereoselective Access to Polyfunctionalized Nine-Membered Heterocycles by Sequential Gold and Palladium Catalysis," Yang, G.; Ke, Y.-M.; Zhao, Y. Angew. Chem. Int. Ed. 2021, 60, 12775-12780. “Access to 5,6-Spirocycles Bearing Three Contiguous Stereocenters via Pd-Catalyzed Stereoselective [4 + 2] Cycloaddition of Azadienes," Sheikh Ismail S. N. F.; Yang, B.;* Zhao, Y.* Org. Lett. 2021, 23, 2884-2889. “Desymmetrization of 1,3-Diones by Catalytic Enantioselective Condensation with Hydrazine," Yang , B.; Dai, J.; Luo, Y.; Lau, K. K.; Lan, Y.;* Shao, Z.;* Zhao, Y.* J. Am. Chem. Soc. 2021, 143, 4179-4186 (Y.B. and D.J. contributed equally). “Ligand Coordination- and Dissociation-Induced Divergent Allylic Alkylations Using Alkynes," Huang, Y.; Ma, C.; Liu, S.; Yang, L.-C.; Lan, Y.;* Zhao, Y.* Chem 2021, 7, 812-826 (H.Y., M.C. and L.S. contributed equally). “Nickel-Catalyzed Site- and Stereoselectivereductive Alkylalkynylation of Alkynes," Jiang, Y.; Pan, J.; Yang, T.; Zhao, Y.;* Koh, M. J.* Chem 2021, 7, 993-1005.