ROWE, Alex - University of Edinburgh - School of Biological Sciences

个人简介

University of Edinburgh (1998 – current) Personal Chair in Molecular Medicine 2009 Renewal of Wellcome Senior Research Fellowship in Basic Biomedical Science (2008 – 2015) Wellcome Senior Research Fellow in Basic Biomedical Science (2002 – 2008) Wellcome Research Career Development Fellow (1998 – 2002) University of Oxford (1997 – 1998) Postdoctoral fellow in Professor Chris Newbold’s laboratory (Wellcome International Prize Travelling Research Fellowship). National Institutes of Health, Bethesda, MD, USA (1995 – 1997) Postdoctoral fellow in Dr Louis Miller’s laboratory. (Wellcome International Prize Travelling Research Fellowship) University of Oxford (1991 – 1995) Graduate student in Professor Chris Newbold’s laboratory. Ludwig Institute for Cancer Research, St Mary’s Hospital, London, UK (1990 – 1991). Research assistant in Dr Fritz Propst’s laboratory. Royal Hallamshire Hospital, Sheffield, UK (1989 – 1990) House officer in general medicine, neurology and orthopaedic surgery. Papua New Guinea Institute of Medical Research, Madang and Goroka, Papua New Guinea (1987 – 1988). Research assistant. Career break: December 2002 – April 2003. Maternity leave. Since returning from maternity leave I have worked part-time (80% FTE from 2003–2013). Degrees: D. Phil. (University of Oxford 1995) M.B. Ch.B. (University of Sheffield 1989)

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Opi, DH, Ugoya, S, Williams, TN, Rowe, JA. 2016.Red blood cell Complement Receptor One level varies with Knops blood group, alpha+thalassaemia and age among Kenyan children.Genes and Immunity doi: 10.1038/gene.2016.2. PDF Semblat, JP, Ghumra, A, Czajkowsky, DM, Mitchell, DA, Wallis, R, Raza, A, Rowe, JA. 2015.Identification of the minimal binding region of a Plasmodium falciparum IgM binding PfEMP1 domain. Molecular and Biochemical Parasitology 201:76-82. doi: 10.1016/j.molbiopara.2015.06.001. PDF Travassos, MA, Niangaly, A, Bailey, JA, Ouattara, A, Coulibaly, D, Laurens, MB, Pablo, J, Jasinskas, A, Nakajima-Sasaki, R, Berry, AA, Takala-Harrison, S, Kouriba, B, Rowe, JA, Lyke, KE, Doumbo, OK, Thera, MA, Felger, PL, Plowe, CV. 2015.Differential recognition of Plasmodium falciparum VAR2CSA fragments by sera from multigravid malaria-exposed Malian women.American Journal of Tropical Medicine and Hygiene 92:1190-1194. doi: 10.4269/ajtmh.14-0524 PDF Adams Y, Khunrae P, Higgins M, Ghumra A, Rowe JA. 2014.Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum Erythrocyte Membrane Protein 1 domains.Infection and Immunity 82:949-959. DOI: 10.1128/IAI.01233-13. PDF Opi DH, Ochola LB, Tendwa M, Siddondo BR, Ocholla H, Fanjo H, Ghumra A, Ferguson DJP, Williams TN*, Rowe JA* (joint senior authors). 2014.Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α+thalassemiaEBioMedicine 1;1:29-36 doi:10.1016/j.ebiom.2014.10.006 PDF Stevenson, L, Huda, P, Jeppesen, A, Laursen, E, Rowe, JA, Craig, A, Streicher, W, Barfod, L, Hviid, L. 2014.Investigating the function of Fc-specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosettingCellular Microbiology 17:819-831. doi: 10.1111/cmi.12403 PDF Rowe JA. 2014.Rosetting (Book chapter)Encyclopedia of Malaria DOI 10.1007/978-1-4614-8757-9_117-1 PDF Arman M, Adams Y, Lindergard G, Rowe JA. 2013.A method for positive and negative selection of Plasmodium falciparum platelet-mediated clumping parasites and investigation of the role of CD36.PLoS ONE 8: e55453. doi:10.1371/journal.pone.0055453 PDF Adams Y, Rowe JA. 2013.The effect of anti-rosetting agents against malaria parasites under physiological flow conditions. PLoS ONE 16;8:e73999. doi: 10.1371/journal.pone.0073999. PDF Travassos M, Niangaly A, Bailey JA, Ouattara A, Coulibaly D, Laurens MB, Pablo J, Jasinskas A, Nakajima-Sasaki R, Berry AA, Takala-Harrison S, Kouriba B, Rowe JA, Lyke KE, Doumbo OK, Thera MA, Felgner PL, Plowe CV. 2013.Seroreactivity to Plasmodium falciparum Erythrocyte Membrane Protein 1 Intracellular Domain in Malaria-Exposed Children and Adults.Journal of Infectious Diseases 208:1514-1519 doi: 10.1093/infdis/jit339 PDF Smith JD, Rowe JA, Higgins MK, Lavstsen T. 2013.Malaria’s Deadly Grip: Cytoadhesion of Plasmodium falciparum-infected erythrocytes.Cellular Microbiology 15:1976-83 doi: 10.1111/cmi.12183. PDF Rowe JA. 2013.Revealing the secrets of malaria parasite interaction with blood group A sugars. (Commentary)Pathogens and Global Health 107: 44-45. PDF Ghumra A, Semblat J-P, Ataide R, Kifude C, Adams Y, Claessens A, Anong DN, Bull PC, Fennell C, Arman M, Amambua-Ngwa A, Walther M, Conway DJ, Kassambara L, Doumbo O, Raza A, Rowe JA. 2012.Induction of Strain-Transcending Antibodies Against Group A PfEMP1 Surface Antigens from Virulent Malaria Parasites.PLoS Pathogens 8: e1002665.doi:10.1371/journal.ppat.1002665 PDF Claessens A, Adams Y, Ghumra A, Lindergard G, Buchan C, Andisi C, Bull PC, Mok S, Gupta AP, Wang CW, Turner L, Arman M, Raza A, Bozdech Z, Rowe JA. 2012.A subset of Group A-like var genes encode the malaria parasite ligands for binding to human brain endothelial cells.Proceedings of the National Academy of Sciences U S A 109:E1772-1781. doi: 10.1073/pnas.1120461109 PDF Tetteh-Quarcoo PB, Schmidt CQ, Tham W-H, Hauhart R, Mertens H, Rowe A, Atkinson, JF, Cowman A, Rowe JA, Barlow PN. 2012.Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 are Driven by Malaria. PLoS ONE 7: e34820. doi:10.1371/journal.pone.0034820 PDF Claessens A, Rowe JA. 2012.Selection of Plasmodium falciparum parasites for cytoadhesion to human brain microvascular endothelial cells.Journal of Visualized Experiments 59:e3122. doi: 10.3791/3122 PDFFor video see http://www.jove.com/video/3122/selection-plasmodium-falciparum-parasites-for-cytoadhesion-to-human Claessens A, Ghumra A, Gupta AP, Mok S, Bozdech Z, Rowe JA. 2011.Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes.Malaria Journal 10:180. doi:10.1186/1475-2875-10-180 PDF(Highly Accessed) Ghumra A, Khunrae P, Ataide R, Raza A, Rogerson SJ, Higgins MK, Rowe JA. 2011.Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.PLoS ONE 6: e16414. doi:10.1371/ journal.pone.0016414 PDF Corrigan RA, Rowe JA. 2010.Strain variation in early innate cytokine induction by Plasmodium falciparum.Parasite Immunology 32:512-527 PDF Czajkowsky DM, Salanti A, Ditlev SB, Shao Z, Ghumra A, Rowe JA, Pleass RJ. 2010.IgM, FcμRs, and Malarial Immune Evasion.Journal of Immunology 184:459-4603 PDF