O'CARROLL, Donal - University of Edinburgh - School of Biological Sciences

个人简介

Prof of Stem Cell Biology, Associate Director, MRC Centre for Regenerative Medicine, 2015; Wellcome Trust Senior Investigator since 2015; ERC Investigator since 2012; Group leader at EMBL Monterotondo 2007 -2015; Adjunct member of faculty, The Rockefeller University since 2007; Postdoctoral research at The Rockefeller University, New York, 2001 - 2007; PhD 1999, Research Institute of Molecular Pathology, Vienna

近期论文

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Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.Guitart, Amelie, Panagopoulou Theano I., Villacreces Arnaud, Vukovic Milica, Sepulveda Catarina, Allen Lewis, Carter Roderick N., van de Lagemaat Louie N., Morgan Marcos, Giles Peter, et al. , J Exp Med, 2017 Mar 06, Volume 214, Issue 3, p.719-735, (2017) Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.Vukovic, Milica, Guitart Amelie, Sepulveda Catarina, Villacreces Arnaud, O'Duibhir Eoghan, Panagopoulou Theano I., Ivens Alasdair, Menendez-Gonzalez Juan, Iglesias Juan Manuel, Allen Lewis, et al. , J Exp Med, 2015 Dec 14, Volume 212, Issue 13, p.2223-34, (2015) Oligoasthenoteratozoospermia and Infertility in Mice Deficient for miR-34b/c and miR-449 Loci.Comazzetto, Stefano, Di Giacomo Monica, Rasmussen Kasper Dindler, Much Christian, Azzi Chiara, Perlas Emerald, Morgan Marcos, and O'Carroll Donal , PLoS Genet, 2014 Oct, Volume 10, Issue 10, p.e1004597, (2014) G9a co-suppresses LINE1 elements in spermatogonia.Di Giacomo, Monica, Comazzetto Stefano, Sampath Srihari C., Sampath Srinath C., and O'Carroll Donal , Epigenetics Chromatin, 2014, Volume 7, p.24, (2014) Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.Grover, Amit, Mancini Elena, Moore Susan, Mead Adam J., Atkinson Deborah, Rasmussen Kasper D., O'Carroll Donal, Jacobsen Sten Eirik W., and Nerlov Claus , J Exp Med, 2014 Feb 10, Volume 211, Issue 2, p.181-8, (2014) Argonaute2 mediates compensatory expansion of the pancreatic β cell.Tattikota, Sudhir G., Rathjen Thomas, McAnulty Sarah J., Wessels Hans-Hermann, Akerman Ildem, van de Bunt Martijn, Hausser Jean, Esguerra Jonathan L. S., Musahl Anne, Pandey Amit K., et al. , Cell Metab, 2014 Jan 7, Volume 19, Issue 1, p.122-34, (2014) MicroRNA-128 governs neuronal excitability and motor behavior in mice.Tan, Chan Lek, Plotkin Joshua L., Ven? Morten T., von Schimmelmann Melanie, Feinberg Philip, Mann Silas, Handler Annie, Kjems J?rgen, D Surmeier James, O'Carroll Donal, et al. , Science, 2013 Dec 6, Volume 342, Issue 6163, p.1254-8, (2013) Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis.Di Giacomo, Monica, Comazzetto Stefano, Saini Harpreet, De Fazio Serena, Carrieri Claudia, Morgan Marcos, Vasiliauskaite Lina, Benes Vladimir, Enright Anton J., and O'Carroll Donal , Mol Cell, 2013 May 23, Volume 50, Issue 4, p.601-8, (2013) General principals of miRNA biogenesis and regulation in the brain.O'Carroll, Donal, and Schaefer Anne , Neuropsychopharmacology, 2013 Jan, Volume 38, Issue 1, p.39-54, (2013) Dicer is selectively important for the earliest stages of erythroid development.Buza-Vidas, Natalija, Cismasiu Valeriu B., Moore Susan, Mead Adam J., Woll Petter S., Lutteropp Michael, Melchiori Luca, Luc Sidinh, Bouriez-Jones Tiphaine, Atkinson Deborah, et al. , Blood, 2012 Sep 20, Volume 120, Issue 12, p.2412-6, (2012) Quantitative functions of Argonaute proteins in mammalian development.Wang, Dongmei, Zhang Zhaojie, O'Loughlin Evan, Lee Thomas, Houel Stephane, O'Carroll Donal, Tarakhovsky Alexander, Ahn Natalie G., and Yi Rui , Genes Dev, 2012 Apr 1, Volume 26, Issue 7, p.693-704, (2012) FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.Mancini, Elena, Sanjuan-Pla Alejandra, Luciani Luisa, Moore Susan, Grover Amit, Zay Agnes, Rasmussen Kasper D., Luc Sidinh, Bilbao Daniel, O'Carroll Donal, et al. , EMBO J, 2012 Jan 18, Volume 31, Issue 2, p.351-65, (2012) The miR-144/451eGFP allele, a novel tool for resolving the erythroid potential of hematopoietic precursors.Rasmussen, Kasper D., and O'Carroll Donal , Blood, 2011 Sep 15, Volume 118, Issue 11, p.2988-92, (2011) Blimp1 regulates the transition of neonatal to adult intestinal epithelium.Muncan, Vanesa, Heijmans Jarom, Krasinski Stephen D., Büller Nikè V., Wildenberg Manon E., Meisner Sander, Radonjic Marijana, Stapleton Kelly A., Lamers Wout H., Biemond Izak, et al. , Nat Commun, 2011, Volume 2, p.452, (2011) The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.De Fazio, Serena, Bartonicek Nenad, Di Giacomo Monica, Abreu-Goodger Cei, Sankar Aditya, Funaya Charlotta, Antony Claude, Moreira Pedro N., Enright Anton J., and O'Carroll Donal , Nature, 2011 Dec 8, Volume 480, Issue 7376, p.259-63, (2011)