MCQUEEN, Heather - University of Edinburgh - School of Biological Sciences

个人简介

1991 PhD, Medical faculty, Edinburgh University 1991-1995 Higher scientific officer, Roslin Institute 1995-1998 Post-doctoral research fellow, ICMB, University of Edinburgh 1998-2001 CRF Personal Fellowship, ICMB, University of Edinburgh 2001-Present Lecturer ICMB, University of Edinburgh

研究领域

The epigenetic control of gene expression, with special focus on the chicken sex chromosome genes. We were first to demonstrate avian dosage compensation for chicken sex chromosome genes and continue to investigate the mechanisms employed in both dosage compensation and sex determination in chickens.

近期论文

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Bisoni L, Batlle-Morera L, Bird AP, Suzuki M, McQueen HA (2005). Female-specific hyperacetylation of histone H4 in the chicken Z chromosome. Chromosome Research 13, 205-214. Bader S, Walker M, McQueen HA, Sellar R, Oie E, Wopereis S, Zhu Y, Peter A, Bird AP, Harrison DJ (2003). MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers. Oncogene 22, 3506-3510. McQueen HA, Derek McBride, Gino Miele, Adrian P Bird, Michael Clinton (2001). Dosage compensation in birds. Current Biology 11, 253-7. Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A (1999). Genomic structure and chromosomal localisation of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. Mammalian Genome 10, 906-912. Clark MS, Edwards YJ, Meek SE, Smith S, Umrania Y, Warner S, Williams G, McQueen HA, Elgar G (1999). Sequence scanning chicken cosmids: A methodology for genome screening. Gene 227, 223-230. McQueen HA, Siriaco G, Bird AP (1998). Chicken microchromosomes are hyper-acetylated, early-replicating and gene-rich. Genome Research 8, 621-30. McQueen HA, Clark VH, Bird AP, Yerle M, Archibald AL (1997). CpG islands of the pig. Genome Research 7, 924-931. McQueen HA, Fantes J, Cross SH, Clark VH, Archibald AL, Bird AP (1996). CpG islands of chicken are concentrated on microchromosomes. Nature Genetics 12, 321-324.