GRIMA, Ramon - University of Edinburgh - School of Biological Sciences

个人简介

2000 B. Sc (Hons), Physics and Pure Mathematics, University of Malta, Malta 2002 M.A. Physics, University of Virginia, USA 2005 Ph.D Physics, Arizona State University, USA 2005-2006 Postdoctoral Fellow, School of Informatics, Indiana University, US 2006-2008 Mathematical Institute Fellow, Imperial College London 2008-present Lecturer, University of Edinburgh

研究领域

Most studies of stochastic biochemical phenomena in the literature are typically addressed via simulations; we take a different approach by developing novel approximate analytical methods which are in many cases computationally more efficient than simulations and which offer a global picture of the dynamics under study. A few approaches we have developed include novel forms of rate equations and chemical langevin equations to deal with conditions characterized by low to intermediate molecule numbers, and a novel form of the chemical master equation which is valid in non-well mixed crowded conditions. Other topics of interest include the development of rigorous methods to obtain low-dimensional descriptions of large reaction networks

近期论文

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Grima R., Thomas P. and Straube A. V. (2011). How accurate are the chemical Langevin and Fokker-Planck equations? J. Chem. Phys. 135: 084103 Thomas P., Straube A. V. and Grima R. (2010). Stochastic theory of large-scale enzyme-reaction networks: finite-copy number corrections to rate equation models. J. Chem. Phys. 133: 195101 Grima R. (2010). An effective rate equation approach to reaction kinetics in small volumes: theory and application to biochemical reactions in nonequilibrium steady-state conditions. J. Chem. Phys. 133: 035101 Grima R. (2010). Intrinsic biochemical noise in crowded intracellular conditions. J. Chem. Phys. 132: 185102 Grima R. (2009). Investigating the Robustness of the Classical Enzyme Kinetic Equations in Small Intracellular compartments. BMC Systems Biology 3:101 Grima R. (2009). Noise-Induced Breakdown of the Michaelis-Menten Equation in Steady-State Conditions. Physical Review Letters 102: 218103 Grima R. and Schnell S. (2008). Modelling reaction kinetics inside cells. Essays in Biochemistry 45: 41 Grima R. and Schnell S. (2006). A Systematic investigation of the rate laws valid in intracellular environments. Biophysical Chemistry 124: 1 Grima R. (2005). Strong coupling dynamics of a multi-cellular chemotactic system. Physical Review Letters 95: 128103 Newman T. J. and Grima R. (2004). Many-body theory of chemotactic interactions. Physical Review E 70: 051916 (2004)