个人简介

B.Sc.(Hons), 1987, National University of Singapore; Ph.D., 1992, National University of Singapore; Research Fellow, 1992-1994 The Scripps Research Institute; Research Fellow, 1994-1996 Institute of Molecular and Cell Biology

研究领域

Bioorganic & Combinatorial Chemistry

Combinatorial and Bioorganic Chemistry Combinatorial chemistry is a powerful technology allowing simultaneous preparation of diverse, novel and biologically active molecules for drug discovery and development. We are particularly interested in exploiting this technology to search for novel organic compounds and natural product derivatives which exhibit interesting biological properties. Specific foci are on the development of potential neurological, anti-cancer and antiviral agents. Green Chemical Synthesis We are also interested in designing new synthetic methodologies that are more environmentally benign, which simplify synthesis and maximize the desired product. We are interested in developing recyclable reagents and catalysts that facilitate reactions in aqueous medium. Figure 1: (A) Inhibition of human lung cancer xenografts growth in vivo by 1g; (B) human lung tumor tissues with in vivo 1g treatment displayed an increase in activated caspase 3 protein expression [J Med Chem, 2010, 53, 7967-7978]. Fluorous, oxime-based palladacycle 1 is a thermally stable and versatile precatalyst that efficiently promotes various carbon-carbon bond formation reactions (Suzuki-Miyaura, Sonogashira and Stille) in aqueous medium under microwave irradiation. Palladacycle 1 gave extremely low levels of Pd leaching and could be reused five times with no significant loss of activity [Green Chem, 2012, 14, 77-80].

近期论文

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W J Ang and Y L Lam. "Allylic and benzylic sp3 C-H oxidation in water" Org Biomol Chem, 2015, 13, 1048-1052 H Huang, C Y Ng, D Yu, J Zhai, Y L Lam and T W Soong. “Modest CaV1.342-selective inhibition by compound 8 is β-subunit dependent” Nature Commun, 2014, DOI 10.1038/ncomms5481 A Datta, S Y Loo, B Huang, L K Wong, S S L Tan, T Z Tan, S-C Lee, J P Thiery, Y C Lim, W P Yong, Y L Lam, A P Kumar and C T Yap. “SphK1 regulates proliferation and survival responses in triple-negative breast cancer” Oncotarget, 2014, Advance Online Publication ISSN: 1949-2553 S. S. L. Tan, L. W Khin, L. Wong, B. Yan, C. W. Ong, A. Datta, M. Salto-Tellez, Y L Lam and C Yap. "Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South Asian population" Clin Transl Gastroenterol, 2014, 5, e51 W J Ang, C-H Tai, L-C Lo and Y L Lam. "Palladium-catalyzed annulation of internal alkyne in aqueous medium" RSC Advances, 2014, 4, 4921-4929. K-F Hua, J-C Chou, Y L Lam, Y-L Tasi, A Chen, S-M Ka, Z Fang, M-L Liu, F-L Yang, Y-L Yang, Y-C Chiu, S-H Wu. "Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression by reducing reactive oxygen species production and mitogen-activated protein kinase activation" PLOS ONE, 2013, 8, e76754. Y. Gao, S Samanta, T Cui and Y L Lam. "Synthesis and In Vitro Evaluation of West Nile Virus Protease Inhibitor Based on the 1,3,4,5-Tetrasubstituted-1H-pyrrol-2(5H)-one Scaffold" ChemMedChem, 2013,8, 1554-1560. K-F Hua, P-C Liao, Z Fang, F-L Yang, Y-LYang, Y-L Chen, Y-C Chiu, M-L Liu, Y L Lam, S-H Wu. “Generation of reactive oxygen species by polyenylpyrroles derivatives causes DNA damage leading to G2/M arrest and apoptosis in human oral squamous cell carcinoma cells” PLOS ONE, 2013, 8, e67603 S Samanta, T L Lim and Y L Lam. “Synthesis and in vitro evaluation of West Nile virus protease inhibitor based on the 2-{6-[2-(5-phenyl-4H-[1, 2, 4] triazol-3-ylsulfanyl) acetylamino] benzothiazol-2-ylsulfanyl} acetamide scaffold” ChemMedChem, 2013, 8, 994-1001. W J Ang,, C-Y Chu, T-C Chou, L-C Lo and Y L Lam. "Application of a recyclable fluorous oxime in the convenient syntheses of 3-amino-1,2-benisoxazoles and 4-amino-1H-2,3-benzoxazines" Green Chem, 2013, 14, 780-785. B Yan, E X Yau, S Samanta, L K Ng, K J Yong, C W Ong, B Bhattacharya, R Soong, K G Yeoh, Y L Lam, M Salto-Tellez. "A Clinical and Therapeutic Relevance for PIM1 Kinase in Gastric Cancer" Gastric Canc, 2012, 15, 188-197 S Sumanta, T Cui and Y L Lam. "Discovery, Synthesis and In Vitro Evaluation of West Nile Virus Protease Inhibitor Based on the 9,10-Dihydro-3H,4aH-1,3,9,10a-tetraaza-phenanthren-4-one Scaffold" ChemMedChem, 2012, 7, 1210-1216. W Susanto, C-Y Chu, W J Ang, T-C Chou, L-C Lo and Y L Lam. "Fluorous Oxime Palladacycle: A Precatalyst for Carbon-Carbon Coupling Reactions in Aqueous and Organic Medium"; J. Org. Chem. 2012, 77, 2729-2742. W Susanto, C-Y Chu, W J Ang, T-C Chou, L-C Lo and Y L Lam. "A Recyclable, Fluorous, Oxime-based Palladacycle Precatalyst for Suzuki-Miyaura Reaction in Aqueous Medium" Green Chem, 2012, 14, 77-80. K H Kong and Y L Lam. "A Versatile Thiouronium-based Solid-phase Synthesis of 1,3,5-Triazines" Chem Eur J, 2012, 18, 1476-1486. C H Soh and Y L Lam. “Sulfones in Solid-phase Heterocycle Synthesis” In Solid-phase Organic Synthesis: Concepts Strategies and Applications, P H Ty and Y L Lam, Eds.; John Wiley & Sons, Inc. USA, 2012, 383-414. Z Fang and Y L Lam. "A Rapid and Convenient Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2-ones and thiones" Tetrahedron, 2011, 67, 1294-1297. W Susanto and Y L Lam. “Oxidation Reactions Using Polymer-Supported 2-Benzenesulfonyl-3-(4-nitrophenyl)oxaziridine” Tetrahedron, 2011, 67, 8353-8359. Z Fang, P-C Liao, Y-L Yang, F-L Yang, Y-L Chen, Y L Lam, K-F Hua, S-H Wu. "Synthesis and Biological Evaluation of Polyenylpyrrole Derivatives as Anti-cancer Agents Acting through Caspases-dependent Apoptosis: J Med Chem, 2010, 53, 7967-7978 J Che and Y L Lam. “Rapid and Regioselective Hydrogenation of a,b-Unsaturated Ketones and Alkylidene Malonic Diesters Using Hantzsch Ester Catalyzed by Titanium Tetrachloride” Synlett, 2010, 2415-2421 S M Ching, W J Tan, K L Chua and Y L Lam. "Synthesis of Cyclic Di-Nucleotidic Acids as Potential Inhibitors Targeting Diguanylate Cyclase" Bioorg Med Chem, 2010, 18, 6657-6665 J Che and Y L Lam. "Polymer-Supported Hantzsch 1,4-Dihydropyridine Ester: An Efficient Biomimetic Hydrogen Source for the Reduction of Ketimines and Electron-Withdrawing Group Conjugated Olefins" Adv Synth Cat, 2010, 352, 1752-1758 C H Soh and Y L Lam. "Microwave-assisted Synthesis of Substituted 2-(Benzylthio) imidazo[1,2a]pyrimidin-5-ones" J Comb Chem, 2010, 12, 286-291 X-K Wee, K-S Ng, H-W Leung, Y-P Cheong, K H Kong, F-M Ng, W Soh, M L Go, Y L Lam, and C-M Low. "Mapping the High-Affinity Binding Domain of 5"-Substituted Benzimidazoles to the Proximal N-terminus of NR2B subunit of NMDA receptor” Brit J Pharmacol, 2010, 159, 449-461. Y Gao, T Cui and Y L Lam. "Synthesis and Disulfide Bond Connectivity-Activity Studies of a Kalata B1-Inspired Cyclopeptide Against Dengue NS2B-NS3 Protease" Bioorg Med Chem, 2010, 18, 1331-1336. Y Gao and Y L Lam. "Synthesis of Pyrazolo[5,1-d] [1,2,3,5] tetrazine-4(3H)-ones" J Comb Chem, 2010, 12, 69-74.