Ge, Shaozhong - National University of Singapore - Department of Chemistry, Faculty of Science

个人简介

Shaozhong was born in Anhui, China in 1980. He received his B.A. in polymer chemistry from University of Science and Technology of China (Hefei, Anhui) in 2002. Then, he moved to Finland to start an international master's program in Åbo Akademi University and got his M. Sc. in chemical engineering in 2004, developing group IV (Zr and Hf) metallocene catalysts for olefin polymerization. As he could not tolerate the extreme weather in Finland, he moved to Univeristy of Groningen in Netherland to continue his graduate study. He studied organo rare earth metal catalysts for olefin functionalization and polymerization, and obtained his Ph.D. degree in 2009 from University of Groningen under the supervision of Prof. Dr. Bart Hessen. From 2010 to 2014, he worked for Prof. John F. Hartwig as a postdoc research associate, developing nickel- and palladium-catalyzed (asymmetric) C-C and C-N cross-coupling chemistry in University of Illinois at Urbana-Champaign and University of California at Berkeley. In January of 2015, he joined the Chemistry Department at National University of Singapore as an Assistant Professor, and was promoted to associate professor with tenure in January of 2021. Employment Jul 2022–Present Dean’s Chair Associate Professor, National University of Singapore Jan 2021–Present Associate Professor of Chemistry, National University of Singapore Jan 2015–Dec 2020 Assistant Professor of Chemistry, National University of Singapore Jul 2011–Dec 2014 Postdoctoral Research Associate, University of California, Berkeley Jan 2010–Jun 2011 Postdoctoral Research Associate, University of Illinois at Urbana-Champaign Education 2005–2009 University of Groningen, Netherlands, Ph.D. in Chemistry 2002–2005 Åbo Akademi University, Finland, M.Sc. in Chemical Engineering 1998–2002 University of Science and Technology of China, Hefei, Anhui, B.Sc. in Applied Chemistry

研究领域

Research in our group focuses on the development of practical transition-metal catalyzed chemcial transformations that address unsolved challenges in synthetic methodology and organic synthesis. The goal is to develop catalytic transformations that can be used in the pharmaceutical industry for synthesis of medicinally relevant molecules and in the upgrading of biomass. The approach to such goal involves the synthesis of well-defined complexes of transition metals, systematic studies of their reactivity, and detailed studies of reaction mechanism. Current research programs in our laboratory include: 1) the development of practical catalysts for the hydrofunctionalization of alkenes; 2) the synthesis of well-defined hydrido-complexes of transition metals for practical (asymmetric) reduction of unstaturated orgnic molecules and CO2; 3) the development of base metal catalysts for cross-coupling reactions and the functionalization of C-H bonds; and 4) the development of well-defined low-valent complexes of transtion metals for the activation of C-C and C-O bonds.

近期论文

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Tan, B. B.;# Hu, M.;# Ge, S.* “Cobalt-Catalyzed Regiodivergent Ring-Opening Dihydroboration of Arylidenecyclopropanes to Access Skipped Diboronates” Angew. Chem. Int. Ed. 2023, 62, e202307176. Yang, X.; Yuan, C.; Ge, S.* “Ligand-enabled stereodivergence in nickel-catalyzed regioselective hydroboration of internal allenes” Chem 2023, 9, 198-215. Li, J.; Ge, S.* “Copper-Catalyzed Quadruple Borylation of Terminal Alkynes to Access sp3-Tetra-Organometallic Reagents” Angew. Chem. Int. Ed. 2022, 61, e202213057. Hu, M.; Tan, B. B.; Ge, S.* “Enantioselective Cobalt-Catalyzed Hydroboration of Fluoroalkyl-Substituted Alkenes to Access Chiral Fluoroalkylboronates” J. Am. Chem. Soc. 2022, 144, 15333–15338. Yang, X.; Ge, S.* “Cobalt-Catalyzed 1,1,3-Triborylation of Terminal Alkynes” Organometallics 2022, 41, 1823–1828 Bai, X.;# Zheng, W.;# Ge, S.*; Lu, Y.* “Enantioselective Palladium-Catalyzed Arylborylation/Cyclization of Alkenes to Access Boryl-Functionalized Heterocyclic Compounds Containing Quaternary Stereogenic Centers” Org. Lett. 2022, 24, 3080–3085. Zhao Y.; Ge, S.* “Synergistic Hydrocobaltation and Borylcobaltation Enable Regioselective Migratory Triborylation of Unactivated Alkenes” Angew. Chem. Int. Ed. 2022, 61, e202116133 You, Y.e.; Ge, S.* “Cobalt-Catalyzed One-Pot Asymmetric Difunctionalization of Alkynes to Access Chiral gem-(Borylsilyl)alkanes” Angew. Chem. Int. Ed. 2021, 60, 20684–20688 Yang, X.; Ge, S.* “Recent Progress in Cobalt-Catalyzed Enantioselective Hydrogenation and Hydroboration Reactions of Alkenes” Curr. Opin. Green and Sustain. Chem. 2021, 31, 100542 You, Y.e.; Ge, S.* “Asymmetric Cobalt-Catalyzed Regioselective Hydrosilylation/Cylcization of 1,6-Enynes” Angew. Chem. Int. Ed. 2021, 60, 12046–12052. Zhao, Y.; Ge, S.* “Chromium-Catalyzed Selective Dimerization/Hydroboration of Allenes to Access Boryl-Functionalized Skipped (E,Z)-Dienes” Angew. Chem. Int. Ed. 2021, 60, 2149–2154. Teo, W. J.;# Yang, X.;# Poon, Y. Y.; Ge, S.* “Cobalt-Catalyzed Deoxygenative Triborylation of Allylic Ethers to Access 1,1,3-Triborylalkanes” Nat. Commun. 2020, 11, 5193. Wu, C.; Ge, S.* “Ligand-Controlled Cobalt-Catalyzed Regiodivergent Hydroboration of Aryl,Alkyl-Disubstituted Internal Allenes” Chem. Sci. 2020, 11, 2783–2789. Hu, M.; Ge, S.* “Versatile Cobalt-Catalyzed Regioselective Chain-Walking Double Hydroboration of 1,n-Dienes to Access gem-Bis(boryl)alkanes” Nat. Commun. 2020, 11, 765. Bai, X.; Wu, C.; Ge, S.*; Lu, Y.* “Pd/Cu-Catalyzed Enantioselective Sequential Heck-Sonogashira Coupling: Asymmetric Synthesis of Oxindoles Containing Trifluoromethylated Quaternary Stereogenic Centers” Angew. Chem. Int. Ed. 2020, 59, 2764–2768. Sang, H. L.; Wu, C.; Phua, G. G. D.; Ge, S.* “Cobalt-Catalyzed Regiodivergent Stereoselective Hydroboration of 1,3-Diynes to Access Boryl-Functionalized Enynes” ACS Catal. 2019, 9, 10109–10114. You, Y.e.; Pham, N. V.; Ge, S. “Copper-Catalyzed Enantioselective Hydroaminomethylation of Alkenes with N,O-Acetals to Access Chiral β-Stereogenic Amines: Dual Functions of the Copper Catalyst” CCS Chem. 2019, 1, 455–463. Sang, H. L.; Hu, Y.; Ge, S.* “Cobalt-Catalyzed Regio- and Stereoselective Hydrosilylation of 1,3-Diynes to Access Silyl-Substituted 1,3-Enynes” Org. Lett. 2019, 21, 5234–5237. Wu, C.; Liao, J.; Ge, S.* “Cobalt-Catalyzed Enantioselective Hydroboration/Cyclization of 1,7-Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers” Angew. Chem. Int. Ed. 2019, 58, 8882–8886 Yu, S.; Sang, H. L.; Zhang, S.-Q.; Hong, X.;* Ge, S.* “Catalytic Asymmetric Synthesis of Chiral Trisubstituted Heteroaromatic Allenes from 1,3-Enynes” Commun. Chem. 2018, 1, 64. Wang, C.; Ge, S.* “Versatile Cobalt-Catalyzed Enantioselective Entry to Boryl-Functionalized All-Carbon Quaternary Stereogenic Centers” J. Am. Chem. Soc. 2018, 140, 10687–10690. Teo, W. J.; Ge, S.* “Cobalt-Catalyzed Enantioselective Synthesis of Chiral gem-Bis(boryl)alkanes” Angew. Chem. Int. Ed. 2018, 57, 12935–12939. Wu, C.; Teo, W. J.; Ge, S.* “Cobalt-Catalyzed (E)-Selective anti-Markovnikov Hydrosilylation of Terminal Alkynes” ACS Catal. 2018, 8, 5896–5900. Sang, H. L.; Yu, S.; Ge, S.* “Copper-Catalyzed Asymmetric Hydroboration of 1,3-Enynes with Pinacolborane to Access Chiral Allenylboronates” Org. Chem. Front. 2018, 5, 1284–1287. Teo, W. J.; Ge, S.* “Cobalt-Catalyzed Diborylation of 1,1-Disubstituted Vinylarenes: A Practical Access to Branched gem-Bis(boryl)alkanes” Angew. Chem. Int. Ed. 2018, 57, 1654–1658. Sang, H. L.; Yu, S.; Ge, S.* “Cobalt-Catalyzed Regioselective Stereoconvergent Markovnikov 1,2-Hydrosilylation of Conjugated Dienes” Chem. Sci. 2018, 9, 973–978. Wang, C.; Teo, W. J.; Ge, S.* “Access to Stereodefined (Z)-Allylsilanes and (Z)-Allylic Alcohols Via Cobalt-Catalyzed Regioselective Hydrosilylation of Allenes” Nat. Commun. 2017, 8, 2258. Yu, S.; Sang, H. L.; Ge, S.* “Enantioselective Copper-Catalyzed Alkylation of Quinoline N-Oxides with Vinylarenes” Angew. Chem. Int. Ed. 2017, 56, 15896–15900. Yu, S.; Wu, C.; Ge, S.* “Cobalt-Catalyzed Asymmetric Hydroboration/Cyclization of 1,6-Enynes with Pinacolborane” J. Am. Chem. Soc. 2017, 139, 6526–6529. Teo, W. J.; Wang, C.; Tan, Y. W.; Ge, S.* “Cobalt-Catalyzed Z-Selective Hydrosilylation of Terminal Alkynes” Angew. Chem. Int. Ed. 2017, 56, 4328–4332. Wang, C.; Teo, W. J.; Ge, S.* “Cobalt-Catalyzed Regiodivergent Hydrosilylation of Vinylarenes and Aliphatic Alkenes: Silane- and Ligand-Dependent Selectivities” ACS Catal. 2017, 7, 855–863. Wang, C.; Wu, C.; Ge, S.* “Iron-Catalyzed E-Selective Dehydrogenative Borylation of Vinylarenes with Pinacolborane” ACS Catal. 2016, 6, 7585–7589.