Clair, David St - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Professor in Psychiatry and Honorary Consultant Psychiatrist with NHS Grampian, Professor David St Clair's career at the University of Aberdeen began in 1995 with a move from Edinburgh where he had held the position of Wellcome Trust Senior Research Fellow at MRC Human Genetics Unit. He holds an advisory professorship at Shanghai Jiaotong University and an adjunct professorship at Columbia University. He has identified pre-natal nutritional deficiency as a major environmental risk factor for schizophrenia and in collaboration with colleagues at Jiaotong and Shanghai large scale field studies have begun to identify the mechanisms responsible

研究领域

Psychiatric Genetics, particularly of schizophrenia

近期论文

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McLean, RT., Wilson, P., St Clair, D., Mustard, CJ. & Wei, J. (in press). 'Differential antibody responses to gliadin-derived indigestible peptides in patients with schizophrenia'. Translational Psychiatry. Lang, B., Zhang, L., Jiang, G., Hu, L., Lan, W., Zhao, L., Hunter, I., Pruski, M., Song, N-N, Huang, Y., Zhang, L., St Clair, D., McCaig, C. & Ding, Y-Q (2016). 'Control of cortex development by ULK4, a rare risk gene for mental disorders including schizophrenia'. Scientific Reports, vol 6, 31126. DOI: [ONLINE] DOI: 10.1038/SREP31126 [ONLINE] AURA: SREP31126.PDF Johnstone, M., Maclean, A., Heyrman, L., Lenaerts, A-S, Nordin, A., Nilsson, L-G, De Rijk, P., Goossens, D., Adolfsson, R., St Clair, DM., Hall, J., Lawrie, SM., McIntosh, AM., Del-Favero, J., Blackwood, DHR. & Pickard, BS. (2015). 'Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness'. Journal of Neuropsychiatry and Clinical Neurosciences, vol 1, no. 3, pp. 175-190. DOI: [ONLINE] DOI: 10.1159/000438788 [ONLINE] AURA: 438788.PDF Jiang, G-Y, Dai, M-H, Huang, K., Chai, G-D, Chen, J-Y, Chen, L., Lang, B., Wang, Q-X, St Clair, D., McCaig, C., Ding, Y-Q & Zhang, L. (2015). 'Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch'. Scientific Reports, vol 5, 12787. DOI: [ONLINE] DOI: 10.1038/SREP12787 [ONLINE] AURA: SREP12787.PDF Xia, K., Guo, H., Xun, G., Zuo, L., Peng, Y., He, Y., Xiong, Z., Sun, L., Pan, Q., Long, Z., Zou, X., Lu, L., Liu, Y., Tian, D., Long, L., Liu, Y., Peng, H., Luo, X., Su, W., Liang, D., Dai, H., Yan, X., Feng, Y., Tang, B., Miedzybrodzka, Z., Xia, J., Zhang, Z., Luo, X., Zhang, X., St Clair, D., Zhao, J. & Zhang, F. (2014). 'Common genetic variants on 1p13.2 associate with risk of autism'. Molecular Psychiatry, vol 19, no. 11, pp. 1212-1219. DOI: [ONLINE] DOI: 10.1038/MP.2013.146 Lang, B., Pu, J., Hunter, I., Liu, M., Martin-Granados, C., Reilly, TJ., Gao, G-D, Guan, Z-L, Li, W-D, Shi, Y-Y, He, G., He, L., Stefansson, H., St Clair, D., Blackwood, DH., McCaig, CD. & Shen, S. (2014). 'Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility'. Journal of Cell Science, vol 127, no. 3, pp. 630-640. DOI: [ONLINE] DOI: 10.1242/?JCS.137604 [ONLINE] AURA: LANG_JCS.PDF Benson, PJ., Beedie, SA., Shephard, E., Giegling, I., Rujescu, D. & St Clair, D. (2012). 'Simple viewing tests can detect eye movement abnormalities that distinguish schizophrenia cases from controls with exceptional accuracy'. Biological Psychiatry, vol 72, no. 9, pp. 716-724. DOI: [ONLINE] DOI: 10.1016/J.BIOPSYCH.2012.04.019 Vassos, E., Steinberg, S., Cichon, S., Breen, G., Sigurdsson, E., Andreassen, OA., Djurovic, S., Morken, G., Grigoroiu-Serbanescu, M., Diaconu, CC., Czerski, PM., Hauser, J., Babadjanova, G., Abramova, LI., Mühleisen, TW., N?then, MM., Rietschel, M., McGuffin, P., Clair, DS., Gustafsson, O., Melle, I., Pietil?inen, OPH., Ruggeri, M., Tosato, S., Werge, T., Ophoff, RA., Rujescu, D., B?rglum, AD., Mors, O., Mortensen, PB., Demontis, D., Hollegaard, MV., van Winkel, R., Kenis, G., De Hert, M., Réthelyi, JM., Bitter, I., Rubino, IA., Golimbet, V., Kiemeney, LA., van den Berg, LH., Franke, B., J?nsson, EG., Farmer, A., Stefansson, H., Stefansson, K., Collier, DA. & GROUP Consortium (2012). 'Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder'. Biological Psychiatry, vol 72, no. 8, pp. 645-650. DOI: [ONLINE] DOI: 10.1016/J.BIOPSYCH.2012.02.040 Keller, MC., Simonson, MA., Ripke, S., Neale, BM., Gejman, PV., Howrigan, DP., Lee, SH., Lencz, T., Levinson, DF., Sullivan, PF., Schizophrenia Psychiatric Genome-Wide Association Study Consortium & St Clair, DM. (2012). 'Runs of homozygosity implicate autozygosity as a schizophrenia risk factor'. PLoS Genetics, vol 8, no. 4, e1002656. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PGEN.1002656 [ONLINE] AURA: RUNS_OF_HOMO.PDF Kim, JY., Liu, CY., Zhang, F., Duan, X., Wen, Z., Song, J., Feighery, E., Lu, B., Rujescu, D., St Clair, D., Christian, K., Callicott, JH., Weinberger, DR., Song, H. & Ming, G. (2012). 'Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia'. Cell, vol 148, no. 5, pp. 1051-1064. DOI: [ONLINE] DOI: 10.1016/J.CELL.2011.12.037