Smith, Tim - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

研究领域

Development of novel tracers for medical imaging Nanoparticles for cancer imaging and therapy Targeted Radiotherapy Using 31P-NMR spectroscopy to probe intracellular pathways Molecular imaging to detect beneficial drug combinations Anticancer drugs and phospholpid metabolism

近期论文

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Phyu, SM., Tseng, C-CT, Fleming, IN. & Smith, TAD. (2016). 'Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3'. Scientific Reports, vol 6, 36544. DOI: [ONLINE] DOI: 10.1038/SREP36544 [ONLINE] AURA: SREP36544.PDF Smith, TAD. & Phyu, SM. (2016). 'Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells'. PloS one, vol 11, no. 3, e0151179. DOI: [ONLINE] DOI: 10.1371/JOURNAL.PONE.0151179 [ONLINE] AURA: JOURNAL.PONE.0151179.PDF Cooper, AC., Fleming, IN., Phyu, SM. & Smith, TAD. (2015). 'Changes in [18F]Fluoro-2-deoxy-D-glucose incorporation induced by doxorubicin and anti-HER antibodies by breast cancer cells modulated by co-treatment with metformin and its effects on intracellular signalling'. Journal of Cancer Research and Clinical Oncology, vol 141, no. 9, pp. 1523-1532. DOI: [ONLINE] DOI: 10.1007/S00432-015-1909-2 [ONLINE] AURA: METFORMINPAPER_CRCO.DOCX Fleming, IN., Andriu, A. & Smith, TAD. (2014). 'Early changes in [18F] FDG incorporation by breast cancer cells treated with trastuzumab in normoxic conditions: Role of the Akt-pathway, glucose transport and HIF-1α'. Breast Cancer Research and Treatment, vol 144, no. 4, pp. 241-248. DOI: [ONLINE] DOI: 10.1007/S10549-014-2858-1 [ONLINE] AURA: AKTINPAPERBCRT.DOCX [ONLINE] AURA: AKTINPAPERBCRT.DOCX Schweiger, LF. & Smith, TAD. (2013). 'Fully-automated Radiosynthesis and In Vitro Uptake Investigation of [N-methyl-11C]methylene Blue'. Anticancer Research, vol 33, no. 10, pp. 4267-4270. Smith, TAD., Zanda, M. & Fleming, IN. (2013). 'Hypoxia stimulates 18F-Fluorodeoxyglucose uptake in breast cancer cells via hypoxia inducible factor-1 and AMP-activated protein kinase'. Nuclear Medicine and Biology, vol 40, no. 6, pp. 858-864. DOI: [ONLINE] DOI: 10.1016/J.NUCMEDBIO.2013.05.006 Trembleau, L., Smith, TAD. & Abdelrahman, MH. (2013). 'Receptor conformational change induces fluoride binding despite competitive water binding'. Chemical Communications, vol 49, no. 52, pp. 5850-5852. DOI: [ONLINE] DOI: 10.1039/C3CC43019G Smith, TAD., Appleyard, MVCL., Sharp, S., Fleming, IN., Murray, K. & Thompson, AM. (2013). 'Response to trastuzumab by HER2 expressing breast tumour xenografts is accompanied by decreased Hexokinase II, glut1 and [18F]-FDG incorporation and changes in 31P-NMR detectable phosphomonesters'. Cancer Chemotherapy and Pharmacology, vol 71, no. 2, pp. 473-480. DOI: [ONLINE] DOI: 10.1007/S00280-012-2032-6 Law, AA., Collie-Duguid, ESR. & Smith, TAD. (2012). 'Influence of resistance to 5-fluorouracil and tomudex on [18F]-FDG incorporation, glucose transport and hexokinase activity'. International Journal of Oncology, vol 41, no. 1, pp. 378-382. DOI: [ONLINE] DOI: 10.3892/IJO.2012.1439 Trembleau, L., Simpson, M., Cheyne, RW., Escofet, I., Appleyard, MVCL., Murray, K., Sharp, S., Thompson, AM. & Smith, TAD. (2011). 'Development of 18F-fluorinatable dendrons and their application to cancer cell targeting'. New Journal of Chemistry, vol 35, no. 11, pp. 2496-2502. DOI: [ONLINE] DOI: 10.1039/C1NJ20417C