Roelofs, Anke - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

I completed my MSc in Medical Biology at the University of Groningen in the Netherlands in 2003 cum laude (with first class honours). I then moved to the University of Oxford where I obtained my DPhil in 2007. After a number of post-doctoral research posts at the University of Aberdeen, I was appointed Lecturer in Skeletal Regenerative Medicine in 2012.

研究领域

The goal of my research has been to achieve a greater understanding of the pharmacology of anti-resorptive bisphosphonate drugs and related compounds. Using fluorescently-labelled bisphosphonates, I studied their skeletal distribution and targetting of cells in vivo, and how this is influenced by bone mineral affinity of the bisphosphonate. I also investigated the mechanisms of their immunomodulatory effects and their in vitro and in vivo anti-tumour activity

近期论文

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Ansboro, S., Roelofs, AJ. & de Bari, C. (2017). 'Mesenchymal stem cells for management of rheumatoid arthritis: immune modulation, repair or both?'. Current Opinion in Rheumatology, vol 29, no. 2, pp. 201-207. DOI: [ONLINE] DOI: 10.1097/BOR.0000000000000370 Sergijenko, A., Roelofs, AJ., Riemen, AHK. & De Bari, C. (2016). 'Bone Marrow Contribution to Synovial Hyperplasia Following Joint Surface Injury'. Arthritis Research & Therapy, vol 18, 166. DOI: [ONLINE] DOI: 10.1186/S13075-016-1060-8 Sun, S., B?a?ewska, KM., Kadina, AP., Kashemirov, BA., Duan, X., Triffitt, JT., Dunford, JE., Russell, RGG., Ebetino, FH., Roelofs, AJ., Coxon, F., Lundy, MW. & McKenna, CE. (2016). 'Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine'. Bioconjugate Chemistry, vol 27, no. 2, pp. 329-340. DOI: [ONLINE] DOI: 10.1021/ACS.BIOCONJCHEM.5B00369 Karystinou, A., Roelofs, AJ., Neve, A., Cantatore, FP., Wackerhage, H. & De Bari, C. (2015). 'Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells'. Arthritis Research & Therapy, vol 17, 147. DOI: [ONLINE] DOI: 10.1186/S13075-015-0639-9 [ONLINE] AURA: S13075_015_0639_9.PDF Cherry, HM., Roelofs, AJ., Kurth, T. & De Bari, C. (2014). 'In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum'. European Cells & Materials, vol 27, pp. 185-195. [ONLINE] AURA: CHERRY_ET_AL_ECM_2014.PDF [LINK] HTTP://WWW.ECMJOURNAL.ORG/JOURNAL/PAPERS/VOL027/VOL027A14.PHP Roelofs, AJ., Stewart, CA., Sun, S., Blazewska, KM., Kashemirov, BA., McKenna, CE., Russell, RGG., Rogers, MJ., Lundy, MW., Ebetino, FH. & Coxon, F. (2012). 'Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo'. Journal of Bone and Mineral Research, vol 27, no. 4, pp. 835-847. DOI: [ONLINE] DOI: 10.1002/JBMR.1543 Moriceau, G., Roelofs, AJ., Brion, R., Redini, F., Ebetino, FH., Rogers, MJ. & Heymann, D. (2012). 'Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth'. Cancer, vol 118, no. 3, pp. 750-760. DOI: [ONLINE] DOI: 10.1002/CNCR.26336 Zhao, Z., Watt, C., Karystinou, A., Roelofs, AJ., McCaig, CD., Gibson, IR. & De Bari, C. (2011). 'Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field'. European Cells & Materials, vol 22, no. -, -, pp. 344-358. [LINK] HTTP://WWW.ECMJOURNAL.ORG/JOURNAL/PAPERS/VOL022/PDF/V022A26.PDF Ford, LA., Roelofs, AJ., Anavi-Goffer, S., Mowat, L., Simpson, DG., Irving, AJ., Rogers, MJ., Rajnicek, AM. & Ross, RA. (2010). 'A role for L-α-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells'. British Journal of Pharmacology, vol 160, no. 3, pp. 762-771. DOI: [ONLINE] DOI: 10.1111/J.1476-5381.2010.00743.X Roelofs, AJ., Coxon, F., Ebetino, FH., Lundy, MW., Henneman, ZJ., Nancollas, GH., Sun, S., Blazewska, KM., Lynn F Bala, J., Kashemirov, BA., Khalid, AB., McKenna, CE. & Rogers, MJ. (2010). 'Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo'. Journal of Bone and Mineral Research, vol 25, no. 3, pp. 606-616. DOI: [ONLINE] DOI: 10.1359/JBMR.091009