Platt, Bettina - University of Aberdeen - School of Medicine, Medical Sciences and Nutrition

个人简介

Bettina Platt graduated with distinction from the University of Mainz, Germany, in 1991 and received her PhD from the University of Düsseldorf, Germany, in 1994. After completing a prestigious personal European Fellowship at the University of Leeds, UK, Prof Platt joined the University of Aberdeen in 1997, initially within the Department of Biomedical Sciences. Prof Platt was promoted to Reader in 2007 and Full Professor (Chair in Translational Neuroscience) within the School of Medical Sciences in 2009. She heads a multi-disciplinary research team that investigates aspects of brain function and malfunction from the single molecule to the systems level. Prof Platt has acted as Research Director for a number of large research initiatives, some of which were co-funded by the pharmaceutical industry and the Scottish government. Her national and international collaborations have brought together novel research strategies, technologies and disciplines such as imaging, drug discovery, electronics, and computer science. Prof Platt has written over 80 full papers and reviews, edited and published books and book chapters in her area of expertise, organized symposia and regularly contributes to national and international conferences. She is a Fellow of the Society of Biology and a founding and Executive Board member of the Scottish Dementia Research Consortium. Additionally, Prof Platt is the lead of the Scottish Alzheimer Research UK (ARUK) network, and a member of the ARUK Scientific Advisory Board as well as the Alzheimer’s Society Grant Advisory Board.

研究领域

Research interests: Mechanisms of neuronal plasticity, neurodegeneration and neuroprotection.

近期论文

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Koss, DJ., Jones, G., Cranston, A., Gardner, H., Kanaan, NM. & Platt, B. (2016). 'Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline'. Acta Neuropathologica, vol 132, no. 6, pp. 875–895. DOI: [ONLINE] DOI: 10.1007/S00401-016-1632-3 [ONLINE] AURA: ART_3A10.1007_2FS00401_016_1632_3.PDF Koss, DJ., Robinson, L., Drever, BD., Plucinska, K., Stoppelkamp, S., Veselcic, P., Riedel, G. & Platt, B. (2016). 'Mutant tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology'. Neurobiology of Disease, vol 91, pp. 105-123. DOI: [ONLINE] DOI: 10.1016/J.NBD.2016.03.002 Plucińska, K., Dekeryte, R., Koss, D., Shearer, K., Mody, N., Whitfield, PD., Doherty, MK., Mingarelli, M., Welch, AE., Riedel, G., Delibegovic, M. & Platt, B. (2016). 'Neuronal human BACE1 knock-in induces systemic diabetes in mice'. Diabetologia, vol 59, no. 7, pp. 1513-1523. DOI: [ONLINE] DOI: 10.1007/S00125-016-3960-1 [ONLINE] AURA: ART_3A10.1007_2FS00125_016_3960_1.PDF Koss, DJ., Robinson, L., Mietelska-Porowska, A., Gasiorowska, A., Sepcic, K., Turk, T., Jaspars, M., Niewiadomska, G., Scott, RH., Platt, B. & Riedel, G. (2015). 'Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits'. Cellular and Molecular Life Sciences, vol 72, no. 23, pp. 4613-4632. DOI: [ONLINE] DOI: 10.1007/S00018-015-1949-4 Jyoti, A., Plano, A., Riedel, G. & Platt, B. (2015). 'Progressive age-related changes in sleep and EEG profiles in the PLB1(Triple) mouse model of Alzheimer's disease'. Neurobiology of Aging, vol 36, no. 10, pp. 2768-2784. DOI: [ONLINE] DOI: 10.1016/J.NEUROBIOLAGING.2015.07.001 Lampert, T., Plano, A., Austin, J. & Platt, B. (2015). 'On the identification of sleep stages in mouse electroencephalography time-series'. Journal of Neuroscience Methods, vol 246, pp. 52-64. DOI: [ONLINE] DOI: 10.1016/J.JNEUMETH.2015.03.007 Goonawardena, AV., Plano, A., Robinson, L., Ross, R., Greig, I., Pertwee, RG., Hampson, RE., Platt, B. & Riedel, G. (2015). 'Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459'. Behavioural Pharmacology, vol 26, no. 3, pp. 289-303. DOI: [ONLINE] DOI: 10.1097/FBP.0000000000000108 Sommerlade, L., Thiel, M., Mader, M., Mader, W., Timmer, J., Platt, B. & Schelter, B. (2015). 'Assessing the strength of directed influences among neural signals: An approach to noisy data'. Journal of Neuroscience Methods, vol 239, pp. 47-64. DOI: [ONLINE] DOI: 10.1016/J.JNEUMETH.2014.09.007 [ONLINE] AURA: OBSERVATIONAL_NOISE.PDF Plucinska, K., Crouch, B., Koss, D., Robinson, L., Riedel, G. & Platt, B. (2014). 'Knock-in of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like PhenoTypes'. Journal of Neuroscience, vol 34, no. 32, pp. 10710-10728. DOI: [ONLINE] DOI: 10.1523/JNEUROSCI.0433-14.2014 [ONLINE] AURA: 10710.FULL.PDF Schelter, B., Mader, M., Mader, W., Sommerlade, L., Platt, B., Lai, Y., Grebogi, C. & Thiel, M. (2014). 'Overarching framework for data-based modelling'. Europhysics Letters, vol 105, no. 3, 30004. DOI: [ONLINE] DOI: 10.1209/0295-5075/105/30004