丁婉婧 - 浙江大学

个人简介

学习经历 2004.9－2008.6 厦门大学医学院药学系，药学，理学学士 2008.9－2013.6 浙江大学药学院，药理学，博士工作经历 2010.7－2012.9 美国University of Southern California，访问学者 2013.6－2015.8 浙江大学海洋学院，博士后 2015.8－2020.12 浙江大学海洋学院，讲师 2021.1-至今浙江大学海洋学院，副教授

研究领域

海洋药物药理学研究

近期论文

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Tang Z, Zhang N, Chen S, Fang J, Tang X, Lou Y, Jiang Y, Ma Y, Chen X, Chen Z*, Zhan S, Ding X, Ding W*, Ma Z*. Bipyridine Derivatives as NOP2/Sun RNA Methyltransferase 3 Inhibitors for the Treatment of Colorectal Cancer. J Med Chem. 2024 Aug 8;67(15):13446-13473. doi: 10.1021/acs.jmedchem.4c01323. Chen X, Ding X, Fang J, Mao C, Gong X, Zhang Y, Zhang N, Yan F, Lou Y, Chen Z*, Ding W*, Ma Z*. Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer. J Med Chem. 2024 Aug 22;67(16):14609-14632. doi: 10.1021/acs.jmedchem.4c01438. Huang Y, Mao CR, Lou Y, Zhan S, Chen Z*, Ding W*, Ma Z*. Design, Synthesis, and Biological Evaluation of an Orally Bioavailable, Potent, and Selective ROCK2 Inhibitor for Psoriasis Treatment. J Med Chem, 2023, doi: 10.1021/acs.jmedchem.3c01297. Wang, J., Gao, T., Ma, Y., Zhang, Y., Yi, Y., Yan, F., Cheng, Z., Yu, Y., Li, J., Chen, Z., Ding, W.*, Ma, Z.* Discovery of unglycosylated indolocarbazoles as ROCK2 isoform-selective inhibitors for the treatment of breast cancer metastasis.(2023) European Journal of Medicinal Chemistry, doi: 10.1016/j.ejmech.2023.115181. Ding W, Zhang H, Mei G. Synergistic antitumor activity of DHA and JQ1 in colorectal carcinoma. Eur J Pharmacol. 2020 ;885:173500. 1 Ding W J, Ji Y Y, Jiang Y J, et al. Gephyromycin C, a novel small-molecule inhibitor of heat shock protein Hsp90, induces G2/M cell cycle arrest and apoptosis in PC3 cells in vitro. Biochem Biophys Res Commun, 2020, 531(3): 377-382. Ding W, Hu Z, Zhang Z, Ma Q, Tang H, Ma Z*, Physapubescin B Exhibits Potent Activity against Human Prostate Cancer In Vitro and In Vivo, J Agric Food Chem, 2015, 63(43): 9504-12. Ding W, Shimada H, Li L, Mittal R, Zhang X, Shudo K, He Q, Prasadarao NV, Wu L*. Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in the differentiation process, Blood, 2013, 121(6):996-1007. Ding W, Cai T, Zhu H, Wu R, Tu C, Yang L, Lu W, He Q, Yang B*. Synergistic antitumor effect of TRAIL in combination with Sunitinib in Vitro and in Vivo, Cancer Lett, 2010, 293(2):158-66. Men RZ, Li N, Ding WJ*, Hu ZJ, Ma ZJ*, Cheng L*, Unprecedent aminophysalin from Physalis angulate, Steroids, 2014; 88: 60-5. Hu Z, Qin L, Wang Q, Ding WJ*, Chen Z, Ma Z*, Angucycline antibiotics and its derivatives from marine-derived actinomycete Streptomyces sp. A6H., Nat Prod Res, 2016, 4:1-8. Hu ZF, Qin LL, Ding WJ*, Liu Y, Ma ZJ*, New analogues of brefeldin A from sediment-derived fungus Penicillium sp. DT-F29, Nat Prod Res, 2016, 30(20): 2311-5.