Searle, Mark - University of Nottingham

个人简介

Searle obtained his B.A. and M.A. in Chemistry from the University of Oxford in 1983 and 1985 respectively. His Ph.D. from the MRC, National Institute for Medical Research, Mill Hill, London followed in 1986. Three years as an Australian Research Council (ARC) Research Fellow preceded his return to the UK as a SERC/GLAXO Research Fellow in Cambridge from 1990 until 1995. In 1995, Dr. Searle was appointed as a Lecturer in Organic Chemistry at the University of Nottingham and promoted through the ranks to full Professor of Biological Chemistry in 2003, serving as Head of School of Chemistry from 2005 to 2013.He is based within the Nottingham Centre for Biomolecular Sciences on the University Park Campus.

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CINI, MELCHIOR, WILLIAMS, HUW, FAY, MIKE W., SEARLE, MARK S., WOODWARD, SIMON and BRADSHAW, TRACEY D., 2016. Enantiopure titanocene complexes - direct evidence for paraptosis in cancer cells METALLOMICS. 8(3), 286-297 SCOTT, DANIEL, OLDHAM, NEIL J., STRACHAN, JO, SEARLE, MARK S. and LAYFIELD, ROBERT, 2015. Ubiquitin-binding domains: Mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes PROTEOMICS. 15(5-6), 844-861 PATEL, ALPA, LEWIS, WILLIAM, SEARLE, MARK S., STEVENS, MALCOLM F. G. and MOODY, CHRISTOPHER J., 2015. Synthesis of 6-arylisocytosines and their potential for hydrogen bonding interactions TETRAHEDRON. 71(39), 7339-7343 KRALOVICOVA J, LAGES A, PATEL A, DHIR A, BURATTI E, SEARLE M and VORECHOVSKY I, 2014. Optimal antisense target reducing INS intron 1 retention is adjacent to a parallel G quadruplex. Nucleic acids research. 42(12), 8161-73 KULKARNI PR, JIA T, KUEHNE SA, KERKERING TM, MORRIS ER, SEARLE MS, HEEB S, RAO J and KULKARNI RV, 2014. A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa. Nucleic acids research. 42(11), 6811-25 REA, SARAH L., MAJCHER, VERONIKA, SEARLE, MARK S. and LAYFIELD, ROB, 2014. SQSTM1 mutations - Bridging Paget disease of bone and ALS/FTLD EXPERIMENTAL CELL RESEARCH. 325(1), 27-37 COUSINS, ALEX R. O., RITSON, DOUGAL, SHARMA, PALLAVI, STEVENS, MALCOLM F. G., MOSES, JOHN E. and SEARLE, MARK S., 2014. Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences CHEMICAL COMMUNICATIONS. 50(96), 15202-15205 SMITH, LINDSAY D., DICKINSON, RACHEL L., LUCAS, CHRISTIAN M., COUSINS, ALEX, MALYGIN, ALEXEY A., WELDON, CARIKA, PERRETT, ANDREW J., BOTTRILL, ANDREW R., SEARLE, MARK S., BURLEY, GLENN A. and EPERON, IAN C., 2014. A Targeted Oligonucleotide Enhancer of SMN2 Exon 7 Splicing Forms Competing Quadruplex and Protein Complexes in Functional Conditions CELL REPORTS. 9(1), 193-205 GOODE, ALICE, LONG, JED E., SHAW, BARRY, RALSTON, STUART H., VISCONTI, MICAELA RIOS, GIANFRANCESCO, FERNANDO, ESPOSITO, TERESA, GENNARI, LUIGI, MERLOTTI, DANIELA, RENDINA, DOMENICO, REA, SARAH L., SULTANA, MELANIE, SEARLE, MARK S. and LAYFIELD, ROBERT, 2014. Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 1842(7), 992-1000 PORTMAN, KATHERINE L., LONG, JED, CARR, STEPHEN, BRIAND, LOIC, WINZOR, DONALD J., SEARLE, MARK S. and SCOTT, DAVID J., 2014. Enthalpy/Entropy Compensation Effects from Cavity Desolvation Underpin Broad Ligand Binding Selectivity for Rat Odorant Binding Protein 3 BIOCHEMISTRY. 53(14), 2371-2379 MORRIS, E.R., HALL, G., LI, C., HEEB, S., KULKARNI, R.V., LOVELOCK, L., SILISTRE, H., MESSINA, M., CÁMARA, M., EMSLEY, J., WILLIAMS, P. and SEARLE, M.S., 2013. Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN Structure. 21(9), 1659-1671 EDWARDS, JOHN M., LONG, JED, DE MOOR, CORNELIA H., EMSLEY, JONAS and SEARLE, MARK S., 2013. Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1 NUCLEIC ACIDS RESEARCH. 41(14), 7153-7166 WRIGHT, TAO, REA, SARAH L., GOODE, ALICE, BENNETT, ANDREW J., RATAJCZAK, THOMAS, LONG, JED E., SEARLE, MARK S., GOLDRING, CHRISTOPHER E., PARK, B. KEVIN, COPPLE, IAN M. and LAYFIELD, ROBERT, 2013. The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone BONE. 52(2), 699-706 IACHETTINI, SARA, STEVENS, MALCOLM F. G., FRIGERIO, MARK, HUMMERSONE, MARC G., HUTCHINSON, IAN, GARNER, THOMAS P., SEARLE, MARK S., WILSON, DAVID W., MUNDE, MANOJ, NANJUNDA, RUPESH, D'ANGELO, CARMEN, ZIZZA, PASQUALE, RIZZO, ANGELA, CINGOLANI, CHIARA, DE CICCO, FEDERICA, PORRU, MANUELA, D'INCALCI, MAURIZIO, LEONETTI, CARLO, BIROCCIO, ANNAMARIA and SALVATI, ERICA, 2013. On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 32, GIANFRANCESCO F, RENDINA D, DI STEFANO M, MINGIONE A, ESPOSITO T, MERLOTTI D, GALLONE S, MAGLIOCCA S, GOODE A, FORMICOLA D, MORELLO G, LAYFIELD R, FRATTINI A, DE FILIPPO G, NUTI R, SEARLE M, STRAZZULLO P, ISAIA G, MOSSETTI G and GENNARI L, 2012. A non-synonymous TNFRSFIIA variation increases NF-kB activity and the severity of Paget's disease. Journal of Bone and Mineral Research. 27, 443-452 STRACHAN, J., ROACH, L., SOKRATOUS, K., TOOTH, D., LONG, J., GARNER, T.P., SEARLE, M.S., OLDHAM, N.J. and LAYFIELD, R., 2012. Insights into the molecular composition of endogenous unanchored polyubiquitin chains Journal of Proteome Research. 11(3), 1969-1980 SEARLE MS, GARNER TP, STRACHAN J, LONG J, ADLINGTON J, CAVEY JR, SHAW B and LAYFIELD R, 2012. Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains. Biochem Soc Transactions. 40(2), 404-408 SOKRATOUS, K., ROACH, L.V., CHANNING, D., STRACHAN, J., LONG, J., SEARLE, M.S., LAYFIELD, R. and OLDHAM, N.J., 2012. Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry Journal of the American Chemical Society. 134(14), 6416-6424 GARNER TP, LONG J, LAYFIELD R, SEARLE MS, 2011. Impact of p62/SQSTM1 UBA Domain Mutations Linked to Paget's Disease of Bone on Ubiquitin Recognition. Biochemistry. 50(21), 4665-74 CHEN, P., EVANS, C.-L., HIRST, J.D. and SEARLE, M.S., 2011. Structural insights into the two sequential folding transition states of the PB1 domain of NBR1 from phi-value analysis and biased molecular dynamics simulations Biochemistry. 50, 125-135 LINDER, J., GARNER, T.P., WILLIAMS, H.E.L., SEARLE, M.S. and MOODY, C.J., 2011. Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes Journal of the American Chemical Society. 133(4), 1044-1051 GARNER, T.P., STRACHAN, J., SHEDDEN, E.C., LONG, J.E., CAVEY, J.R., SHAW, B., LAYFIELD, R. and SEARL, M.S., 2011. Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex. Biochemistry. 50(42), 9076-9087