Bo. Guillaume De - The University of Manchester

个人简介

In 2004 Guillaume obtained a Master in Chemistry from the Catholic University of Louvain (Belgium). He did his master thesis under the supervision of Prof István E. Markó on the development of platinum-based catalysts for the hydrosilylation of alkynes. He completed his PhD in 2009, in the same laboratory, working on the synthesis of angular triquinanes. He then took a post-doctoral position in the laboratory of Prof Jean-François Gohy and Charles-André Fustin (UCL, Belgium) to work on the assembly of mechanically-linked block copolymers. In 2011, he joined the group of Prof David A. Leigh, then in Edinburgh, to work on the development of molecular machines. In 2015 he was awarded a Royal Society University Research Fellowship held at the University of Manchester to investigate the use of mechanical force in synthesis. He was promoted to Professor of Organic Chemistry in 2022.

研究领域

Mechanical force is a formidable, and relatively unexplored, source of energy that, with its ability to distort, bend and stretch chemical bonds, is unique in the way it activates chemical reactions. The precise control of this force could revolutionise how we build and rearrange molecular structures and change the way we think about chemical transformations. Precise control of this force can be achieved when the chemical entity that is the subject of the mechanical force (a “mechanophore”) is embedded within a polymeric backbone. Indeed, pulling both ends of a macromolecule apart creates highly directional strain with its highest intensity in the middle of the chain. The aim of our research is to design, synthesize and study new mechanophores that can catalytically harness mechanical energy to induce unusual chemical transformations.

近期论文

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Force-controlled release of small molecules with a rotaxane actuator Chen, L., Nixon, R. & De Bo, G., 10 Apr 2024, In: Nature (London). 628, p. 320-325 Force-Promoted Transformations in Mechanically Linked Molecules Ormson, J., Duwez, A. S. & De Bo, G., 2024, Mechanically Interlocked Materials: Polymers, Nanomaterials, MOFs and more. Pérez, E. (ed.). John Wiley & Sons Ltd, p. 1-28 Bond breaking of furan–maleimide adducts via a diradical sequential mechanism under an external mechanical force Cardosa-Gutierrez, M., De Bo, G., Duwez, A-S. & Remacle, F., 7 Feb 2023, In: Chemical Science. 14, 5, p. 1263-1271 9 p. Furan Release via Force-Promoted Retro-[4+2][3+2] Cycloaddition Suwada, K., Ieong, W., Lo, H. L. H. & De Bo, G., 27 Sept 2023, In: Journal of the American Chemical Society. 145, 38, p. 20782–20785 4 p. Mechanical stability of cis, trans - poly(p-phenylene vinylenes) Janpatompong, Y., Suwada, K., Turner, M. & De Bo, G., 28 Apr 2023, In: Polymer Chemistry. p. 1978-1982 Cooperative and Geometry-Dependent Mechanochromic Reactivity through Aromatic Fusion of Two Rhodamines in Polymers Wu, M., Li, Y., Yuan, W., De Bo, G., Cao, Y. & Chen, Y., 21 Sept 2022, In: Journal of the American Chemical Society. Stereoelectronic effects in force-accelerated retro-Diels–Alder reactions Wu, L. C. & De Bo, G., Mar 2022, In: SYNLETT. A Catenane as a Mechanical Protecting Group: Journal of the American Chemical Society Zhang, M. & De Bo, G., 18 Mar 2020, In: J. Am. Chem. Soc.. 142, 11, p. 5029-5033 5 p. A mechanochromic hydrogen bonded rotaxane De Bo, G., 12 Oct 2020, (E-pub ahead of print) In: Macromolecular rapid communications. A Track-Based Molecular Synthesizer that Builds a Single-Sequence Oligomer Through Iterative Carbon-Carbon Bond Formation Mcternan, C., De Bo, G. & Leigh, D., 15 Oct 2020, In: Chem. 6, 11, p. 2964-2973 10 p. Expedient Synthesis of Heterobifunctional Triarylmethane Stoppers for Macromolecular Rotaxanes Zhang, M., Shvetsova, O. & De Bo, G., 21 Feb 2020, In: The Journal of organic chemistry. 85, 4, p. 2770-2774 5 p. Isotope Effect in the Activation of a Mechanophore Nixon, R. & De Bo, G., 31 Dec 2020, In: J. Am. Chem. Soc.. Mechanical activation of polymers containing two adjacent mechanophores Stevenson, R., Zhang, M. & De Bo, G., 2020, In: Polymer Chemistry. Polymer Mechanochemistry and the Emergence of the Mechanophore Concept De Bo, G., 22 Sept 2020, In: Macromolecules. 53, 18, p. 7615-7617 Three concomitant C-C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor Nixon, R. & De Bo, G., 20 Jul 2020, In: Nature Chemistry. 12, p. 826-831 Zhang, M. & De Bo, G., 2019, In: J. Am. Chem. Soc.. Research output: Contribution to journal › Article › peer-review An artificial molecular machine that builds an asymmetric catalyst De Bo, G., Gall, M. A. Y., Kuschel, S., De Winter, J., Gerbaux, P. & Leigh, D. A., 1 May 2018, In: Nature Nanotechnology. 13, 5, p. 381-385 5 p. Emerging investigators in the UK – editorial Bo, G. D., Kitchen, J. A. & Serpell, C. J., 2 Sept 2018, In: Supramolecular Chemistry. 9, p. 731 1 p. Zhang, M. & De Bo, G., 28 Sept 2018, In: Journal of the American Chemical Society. 140, 40, p. 12724-12727 4 p.