Li, Gang - Utah State University - Department of Chemistry and Biochemistry

个人简介

Gang (pronounced as G-ah-ng) was born and raised in Chongqing, a secret metropolis in southwestern China famous for spicy food and beautiful scenery. He obtained his B.S. from Wuhan University, working with Prof. Aiwen Lei on Pd-catalyzed cross-coupling reactions. Fascinated by the power of transition-metal complexes, he decided to go across the Pacific Ocean to learn more about the mechanisms of transition-metal catalyzed reactions with Prof. Jack R. Norton at Columbia University. After obtaining his Ph.D. from Columbia, he decided to move to the other side of the Hudson River and learn how transition-metal complexes can serve as models of metalloenzymes with Prof. John T. Groves at Princeton University. He was supported by Bristol-Myers Squibb Postdoctoral Fellowship which allowed him to collaborate with the world-renowned pharmaceutical company Bristol-Myer Squibb and apply his knowledge in medicinal chemistry. Gang joins the faculty at Utah State University in summer 2019.

研究领域

Design and synthesis of bioinspired transition-metal complexes that mimic metalloenzymes Investigating reaction mechanisms to gain insightful information to guide new reaction design Development of new chemical transformations that meet the criteria of sustainable chemistry

近期论文

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Cooperative Fe/Co Catalyzed Remote Desaturation for the Synthesis of Unsaturated Amide Derivatives Wan, Y.; Ramirez E.; Ford, A.^; Zhang, H. K.; Norton, J. R.*; Li, G.* J. Am. Chem. Soc. 2024, 146, 4985-4992. Preprint available: https://doi.org/10.26434/chemrxiv-2023-27mjd Hydrogen Atom Transfer (HAT)-Mediated Remote Desaturation Enabled by Fe/Cr-H Cooperative Catalysis Wan, Y.; Adda, A.;Qian, J.; Vaccaro, D.; He, P.; Li, G.*; Norton, J. R.* J. Am. Chem. Soc. 2024, 146, 4795-4802. Preprint available: https://doi.org/10.21203/rs.3.rs-3260796/v1 Rapid Olefin Cyclopropanation Catalyzed by a Bioinspired Cobalt Complex Tan, L.; Wu, K.; Li, G.* Chem. Asian J. 2023, e202300873. Highlighted in European Journal of Organic Chemistry Hot Topic: Earth-Abundant Transition Metal Catalysis. Fe-Catalyzed C(sp3)–H Diversification toward γ-Functionalized Amides via Iron Nitrenoid: Mechanistic Insights and Applications Wan, Y.; Ramirez, L.; Ford, A.^; Bustamante, V,^; Li, G.* ACS Catal. 2023, 13, 14023. C(sp3)–H Oxidation and Chlorination Catalysed by A Bioinspired Pincer Iron(III) Complex Han, J.; Tan, L.; Wan, Y.; Li, G.*; Anderson, S. N. Dalton Trans. 2022, 51, 11620. Bioinspired C(sp3)–H Functionalization by High-Valent Iron/Manganese Oxo Complexes and Applications in Organic Syntheses Wan, Y.; Tan, L.; Wu, K.; Li, G.* in Handbook of CH-Functionalization 2022, ed. by D. Maiti (Book Chapter) Chloride-Mediated Electrochemical Synthesis of Oxazolines Wu, W.; Li, G.*; Liu, T. L.* Chem Catal. 2021, 1, 966. Unmasking the Ligand Effect in Manganese-Catalyzed Hydrogenation: Mechanistic Insight and Catalytic Application Wang, Y.; Zhu, L.; Shao, Z.; Li, G.; Lan, Y.*; Liu, Q.* J. Am. Chem. Soc. 2019, 141, 13774. Manganese-Catalyzed Desaturation of N-Acyl Amines and Ethers Li, G.; Kates, P. A.; Dilger, A. K.; Cheng, P. T., Ewing, W. R., Groves, J. T.* ACS Catal. 2019, 9, 9513. Selective C-H Halogenations with a Highly Fluorinated Manganese Porphyrin Li, G.; Dilger, A. K.; Cheng, P. T., Ewing, W. R., Groves, J. T.* Angew. Chem., Int. Ed. 2018, 57, 1251. Radical Isomerization and Cycloisomerization Initiated by H• Transfer Li, G.; Kuo, J. L.; Han, A.; Abuyuan, J. M.; Young, L. C.; Norton, J. R.*; Palmer, J. H. J. Am. Chem. Soc. 2016, 138, 7698. Dihydrogen Activation by Cobaloximes with Various Axial Ligands. Li, G.; Estes, D. P.; Norton, J. R.*; Ruccolo, S. Sattler, A., Sattler, W. Inorg. Chem., 2014, 53, 10743. Kinetics and Mechanism of the Hydrogenation of the CpCr(CO)3•/[CpCr(CO)3]2 Equilibrium to CpCr(CO)3H. Norton, J. R.*; Spataru, T.; Camaioni, D. M.; Lee, S. –J.; Li, G.; Choi, J.; Franz. J. A. Organometallics 2014, 33, 2496. Effect of Double-Bond Substituents on the Rate of Cyclization of α-Carbomethoxyhex-5-enyl Radicals. Han, A.; Spataru. T.; Hartung, J.; Li, G.; Norton, J. R.* J. Org. Chem. 2014, 79, 1938. Evidence for Formation of a CoH Bond from (H2O)2Co(dmgBF2)2 under H2: Application to Radical Cyclizations. Li, G.; Han, A.; Pulling, M. E.; Estes, D. P.; Norton, J. R.*, J. Am. Chem. Soc. 2012, 134, 14662. Pd-Catalyzed Direct and Selective C-H Functionalization: C3-Acetoxylation of Indoles. Liu, Q.; Li, G.; Yi, H.; Wu, P.; Liu, J.; Lei, A.* Chem. Eur. J. 2011, 17, 2353. Palladium-Catalyzed Aerobic Oxidative Carbonylation of Arylboronate Esters under Mild Conditions. Liu, Q.; Li, G.; He, J.; Liu, J.; Li, P.; Lei, A.* Angew. Chem., Int. Ed. 2010, 49, 3371. Revealing a Second Transmetalation Step in the Negishi Coupling and Its Competition with Reductive Elimination: Improvement in the Interpretation of the Mechanism of Biaryl Syntheses. Liu, Q.; Lan, Y.; Liu, J.; Li, G.; Wu, Y.*; Lei, A.* J. Am. Chem. Soc. 2009, 131, 10201. An Electron-Deficient Diene as Ligand for Palladium-Catalyzed Cross-Coupling Reactions: An Efficient Alkylation of Aryl Iodides by Primary and Secondary Alkylzinc Reagents. Liu, Q.; Duan, H.; Luo, X.; Tang, Y.; Li, G.; Huang, R.; Lei, A.* Adv. Synth. Catal. 2008, 350, 1349.