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1983年至1988年攻读北京农业大学动物生理生化杨传任教授的硕士和博士学位研究生,从事生殖内分泌学的研究。1991年至1994年,公派到丹麦国家教学研究医院(Rigshospitalet)生殖生物学实验室做博士后研究工作,师从国际著名胚胎学家Anne Grete Byskov教授,从事胚胎卵巢中卵母细胞的发育调控的研究。1994年回到母校中国农业大学工作,并在当年破格提升为教授。在回国人员启动基金和国家自然科学基金的资助下,继续研究促性腺激素诱导卵母细胞体外成熟的作用机制。已经培养70余名博士研究生、10余名硕士研究生及多名博士后,其中十余名学生已在全国高等院校及科研院所担任教授或研究员,奋斗在生殖生物学领域的教学科研岗位上。 目前实验室主要从事雌性哺乳动物卵母细胞减数分裂恢复的分子机理、原始卵泡形成及激活的调控机制研究,已在Nature、Science、JCI、PNAS、Development、Cell Mol Life Sci、J Cell Sci、Cell Death Disease、Endocrinology、Mol Endocrinol、J Lipid Res、Biol Reprod、J Biol Chem、Mol Cell Endocrinol、J Cell Physiol、J Endocrinol、等国际学术杂志发表研究论文100余篇,被引1600余次。在2010年发表在Science的关于卵泡颗粒细胞分泌的C型钠肽通过其受体NPR2抑制卵母细胞成熟的工作引起了极大反响,为揭示卵母细胞成熟的分子机制提供了重要的理论依据。主编《生殖生物学》及《动物生理学》等高教精品教材。 获奖情况 "973"项目首席科学家,国家杰出青年基金获得者,“宝钢优秀教师”获得者,北京市优秀教师,北京市优秀教育工作者 承担项目及课题 目前承担国家重点研发项目子课题1项,主持国家自然科学基金1项,北京市自然基金项目1项 社会兼职 担任中国畜牧兽医学会动物生理生化分会理事长、中国生殖生物学会副理事长、中国生理学会理事、中国动物学会教学工作委员会委员及教育部生物学教学指导委员会委员。中国科学院动物所国家重点“生殖生物学国家实验室”学术委员会委员,内蒙古大学“哺乳动物胚胎工程及生物技术”教育部重点实验室学术委员会委员和宁夏大学“分子生物学及生物技术”教育部重点实验室学术委员会副主任等学术工作。

研究领域

研究内容包括哺乳动物卵母细胞减数分裂成熟的分子机制;调控原始卵泡形成及激活的关键信号转导

近期论文

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Hao Yan, Jiawei Zhang, Jia Wen, Yibo Wang, Wanbao Niu, Zhen Teng, Tongtong Zhao, Yanli Dai, Yan Zhang, Chao Wang, Yingying Qin, Guoliang Xia, Hua Zhang. CDC42 in oocytes controls the activation of primordial follicles by regulating PI3K signaling in mice. BMC Biology 2018 16:3 Xiao Wang#, Huarong Wang#, Wei Liu, Zhiyuan Zhang, Yanhao Zhang, Wenqiang Zhang, Zijiang Chen, Guoliang Xia, Chao Wang. High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice. Clinical Science, 2018 132:759-776. Zhao Y, Zhang Y, Li J, Zheng N, Xu X, Yang J, Xia G, Zhang M. 2018. MAPK3/1 participates in the activation of primordial follicles through mTORC1-KITL signaling. Journal Of Cellular Physiology 233:226-237. Xin Q, Kong S, Yan J, Qiu J, He B, Zhou C, Ni Z, Bao H, Huang L, Lu J, Xia G, Liu X, Chen Z-J, Wang C, Wang H. 2018. Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation. Journal Of Clinical Investigation 128:175-189. Wang X, Wang H, Liu W, Zhang Z, Zhang Y, Zhang W, Chen Z, Xia G, Wang C. 2018. High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice. Clinical science (London, England : 1979) 132:759-776. Huang K, Wang Y, Zhang T, He M, Sun G, Wen J, Yan H, Cai H, Yong C, Xia G, Wang C. 2018. JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice. Biology open 7. Zhang Y, Wang H, Liu W, Yang Y, Wang X, Zhang Z, Guo Q, Wang C, Xia G. 2017. Natriuretic peptides improve the developmental competence of in vitro cultured porcine oocytes. Reproductive Biology and Endocrinology 15:(30 May 2017)-(30 May 2017). Yang Y, Yang C-R, Han SJ, Daldello EM, Cho A, Martins JPS, Xia G, Conti M. 2017. Maternal mRNAs with distinct 3 ' UTRs define the temporal pattern of Ccnb1 synthesis during mouse oocyte meiotic maturation. Genes & Development 31:1302-1307. Xin Q, Li M, Wang H, Cui S, Xia G, Kong S. 2017. Transcript analysis identifies differential uterine gene expression profile beyond the normal implantation window in mice. Theriogenology 104:55-61. Wang C, Zhou B, Xia G. 2017. Mechanisms controlling germline cyst breakdown and primordial follicle formation. Cellular And Molecular Life Sciences 74:2547-2566. Wang C, Sun G, Wang Y, Kong N, Chi Y, Yang L, Xin Q, Teng Z, Wang X, Wen Y, Li Y, Xia G. 2017. Bacterial magnetic particles improve testes-mediated transgene efficiency in mice. Drug Delivery 24:651-659. Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng G-S, Xia G, Lu Z, Wang C, Wang H. 2017. Nuclear Shp2 directs normal embryo implantation via facilitating the ERa tyrosine phosphorylation by the Src kinase. Proceedings Of the National Academy Of Sciences Of the United States Of America 114:4816-4821. Liu W, Xin Q, Wang X, Wang S, Wang H, Zhang W, Yang Y, Zhang Y, Zhang Z, Wang C, Xu Y, Duan E, Xia G. 2017. Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals. Cell Death & Disease 8. Kong N, Xu X, Zhang Y, Wang Y, Hao X, Zhao Y, Qiao J, Xia G, Zhang M. 2017. Natriuretic peptide type C induces sperm attraction for fertilization in mouse. Scientific Reports 7. Zhao L, Du X, Huang K, Zhang T, Teng Z, Niu W, Wang C, Xia G. 2016. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Scientific Reports 6. Niu W, Wang Y, Wang Z, Xin Q, Wang Y, Feng L, Zhao L, Wen J, Zhang H, Wang C, Xia G. 2016. JNK signaling regulates E-cadherin junctions in germline cysts and determines primordial follicle formation in mice. Development 143:1778-1787. Hao X, Wang Y, Kong N, Zhang Y, Zhao Y, Xia G, Zhang M. 2016. Epidermal Growth Factor-Mobilized Intracellular Calcium of Cumulus Cells Decreases Natriuretic Peptide Receptor 2 Affinity for Natriuretic Peptide Type C and Induces Oocyte Meiotic Resumption in the Mouse. Biology Of Reproduction 95. Feng L, Wang Y, Cai H, Sun G, Niu W, Xin Q, Tang X, Zhang J, Wang C, Zhang H, Xia G. 2016. ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice. Journal Of Cell Science 129:2202-2212. Fang J, Wang H, Miao L, Kuang X, Ma W, Wang C, Zhang J, Xia G. 2016. Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevist. Biology Of Reproduction 95. Zhao Q, Liu S, Zhang H, Li N, Wang X, Cao Y, Ning L, Duan E, Xia G. 2015. Spatiotemporal Expression of p63 in Mouse Epidermal Commitment. International Journal Of Molecular Sciences 16:29542-29553. Zhang W, Yang Y, Liu W, Chen Q, Wang H, Wang X, Zhang Y, Zhang M, Xia G. 2015. Brain Natriuretic Peptide and C-Type Natriuretic Peptide Maintain Porcine Oocyte Meiotic Arrest. Journal Of Cellular Physiology 230:71-81. Wang Z, Niu W, Wang Y, Teng Z, Wen J, Xia G, Wang C. 2015. Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary. Plos One 10. Wang Y, Teng Z, Li G, Mu X, Wang Z, Feng L, Niu W, Huang K, Xiang X, Wang C, Zhang H, Xia G. 2015. Cyclic AMP in oocytes controls meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary. Development 142:343-351. Teng Z, Wang C, Wang Y, Huang K, Xiang X, Niu W, Feng L, Zhao L, Yan H, Zhang H, Xia G. 2015. S100A8, An Oocyte-Specific Chemokine, Directs the Migration of Ovarian Somatic Cells During Mouse Primordial Follicle Assembly. Journal Of Cellular Physiology 230:2998-3008. Zheng-Pin Wang, Xin-Yi Mu1, Meng Guo2, Yi-Jing Wang, Zhen Teng, Guan-Ping Mao, Wan-Bao Niu, Li-Zhao Feng, Li-Hua Zhao and Guo-Liang Xia (2014). "Transforming Growth Factor-beta Signaling Participates in the Maintenance of the Primordial Follicle Pool in the Mouse Ovary." J Biol Chem 289(12): 8299-8311. Liu S, Wang X, Zhao Q, Liu S, Zhang H, Shi J, Li N, Lei X, Zhao H, Deng Z, Cao Y, Ning L, Xia G, Duan E. 2015. Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27(KIP1)/p15(INK4b) signaling. Cellular And Molecular Life Sciences 72:2949-2960. Zhang Y, Hao X, Xiang X, Wei K, Xia G, Zhang M. 2014. Porcine Natriuretic Peptide Type B ( pNPPB) Maintains Mouse Oocyte Meiotic Arrest Via Natriuretic Peptide Receptor 2 ( NPR2) in Cumulus Cells. Molecular Reproduction And Development 81:462-469. Zhang W, Chen Q, Yang Y, Liu W, Zhang M, Xia G, Wang C. 2014. Epidermal Growth Factor-Network Signaling Mediates Luteinizing Hormone Regulation of BNP and CNP and Their Receptor NPR2 During Porcine Oocyte Meiotic Resumption. Molecular Reproduction And Development 81:1030-1041. Tu Z, Ran H, Zhang S, Xia G, Wang B, Wang H. 2014. Molecular determinants of uterine receptivity. International Journal Of Developmental Biology 58:147-154. Chen Q, Zhang W, Ran H, Feng L, Yan H, Mu X, Han Y, Liu W, Xia G, Wang C. 2014. PKC delta and theta Possibly Mediate FSH-Induced Mouse Oocyte Maturation via NOX-ROS-TACE Cascade Signaling Pathway. Plos One 9. Zhang J, Gao W, Yang X, Kang J, Zhang Y, Guo Q, Hu Y, Xia G, Kang Y. 2013. Tolerogenic Vaccination Reduced Effector Memory CD4 T Cells and Induced Effector Memory Treg Cells for Type I Diabetes Treatment. Plos One 8. Zhang J, Gao W, Guo Q, Huang B, Wang B, Xia G, Kang Y. 2013. Helminth Protein Vaccine Induced Follicular T Helper Cell for Enhancement of Humoral Immunity against Schistosoma japonicum. Biomed Research International doi:10.1155/2013/798164. Zhang C, Wang X, Wang Z, Niu W, Zhu B, Xia G. 2013. Effect of Different Culture Systems and 3, 5, 3 '-Triiodothyronine/Follicle-Stimulating Hormone on Preantral Follicle Development in Mice. Plos One 8. Wang Y, Kong N, Li N, Hao X, Wei K, Xiang X, Xia G, Zhang M. 2013. Epidermal Growth Factor Receptor Signaling-Dependent Calcium Elevation in Cumulus Cells Is Required for NPR2 Inhibition and Meiotic Resumption in Mouse Oocytes. Endocrinology 154:3401-3409. Mu X, Wen J, Guo M, Wang J, Li G, Wang Z, Wang Y, Teng Z, Cui Y, Xia G. 2013. Retinoic acid derived from the fetal ovary initiates meiosis in mouse germ cells. Journal Of Cellular Physiology 228:627-639. Liu L, Kong N, Xia G, Zhang M. 2013. Molecular control of oocyte meiotic arrest and resumption. Reproduction Fertility And Development 25:463-471. Han Y, Xia G, Tsang BK. 2013. Regulation of Cyclin D2 Expression and Degradation by Follicle-Stimulating Hormone During Rat Granulosa Cell Proliferation In Vitro. Biology Of Reproduction 88. Gao W, Sun Y, Chen S, Zhang J, Kang J, Wang Y, Wang H, Xia G, Liu Q, Kang Y. 2013. Mushroom lectin enhanced immunogenicity of HBV DNA vaccine in C57BL/6 and HBsAg-transgenic mice. Vaccine 31:2273-2280. Bian F, Mao G, Guo M, Mao G, Wang J, Li J, Han Y, Chen X, Zhang M, Xia G*. Gradients of natriuretic peptide precursor A (NPPA) in oviduct and of natriuretic peptide receptor 1 (NPR1) in spermatozoon are involved in mouse sperm chemotaxis and fertilization. J Cell Physiol. 2012 May;227(5):2230-9. Zhang M, Xia G. 2012. Hormonal control of mammalian oocyte meiosis at diplotene stage. Cellular And Molecular Life Sciences 69:1279-1288. Zhang C, Niu W, Wang Z, Wang X, Xia G. 2012. The Effect of Gonadotropin on Glucose Transport and Apoptosis in Rat Ovary. Plos One 7. Wang J, Chen Q, Zhou J, Wen J, Bian F, Li G, Mu X, Han Y, Xia G, Zhang M. 2012. Specific Protein Kinase C Isoforms alpha And beta I Are Involved in Follicle-Stimulating Hormone-Induced Mouse Follicle-Enclosed Oocytes Meiotic Resumption. Plos One 7. Li J, Mao G, Xia G. 2012. FSH Modulates PKAI and GPR3 Activities in Mouse Oocyte of COC in a Gap Junctional Communication (GJC)-Dependent Manner to Initiate Meiotic Resumption. Plos One 7. Kang Y, Zheng G, Chen A, Wang J, Hu Y, Li J, Zhang J, Gao W, Fu H, Xia G, Wang B. 2012. Tolerogenic DNA Vaccine for Prevention of Autoimmune Ovarian Disease. Immunological Investigations 41:249-260. Kang Y, Sun Y, Zhang J, Gao W, Kang J, Wang Y, Wang B, Xia G. 2012. Treg Cell Resistance to Apoptosis in DNA Vaccination for Experimental Autoimmune Encephalomyelitis Treatment. Plos One 7. Han Y, Yan J, Zhou J, Teng Z, Bian F, Guo M, Mao G, Li J, Wang J, Zhang M, Xia G. 2012. Acute fasting decreases the expression of GLUT1 and glucose utilisation involved in mouse oocyte maturation and cumulus cell expansion. Reproduction Fertility And Development 24:733-742. Guo M, Zhang H, Bian F, Li G, Mu X, Wen J, Mao G, Teng Z, Xia G, Zhang M. 2012. P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis. Frontiers in bioscience (Elite edition) 4:2631-44. Zhang M, Su Y-Q, Sugiura K, Wigglesworth K, Xia G, Eppig JJ. 2011. Estradiol Promotes and Maintains Cumulus Cell Expression of Natriuretic Peptide Receptor 2 (NPR2) and Meiotic Arrest in Mouse Oocytes In Vitro. Endocrinology 152:4377-4385. Zhang C, Xia G, Tsang BK. 2011. Interactions of thyroid hormone and FSH in the regulation of rat granulosa cell apoptosis. Frontiers in bioscience (Elite edition) 3:1401-13. Li G, Zhang H, Wang Y, Wen J, Teng Z, Mao G, Wang J, Guo M, Mu X, Xia G. 2011. Stage-specific mice ovarian somatic cell is involved in primordial folliculogenesis. Frontiers in bioscience (Elite edition) 3:1025-33. Zhang M, Su Y-Q, Sugiura K, Xia G, Eppig JJ. 2010. Granulosa Cell Ligand NPPC and Its Receptor NPR2 Maintain Meiotic Arrest in Mouse Oocytes. Science 330:366-369. Wang F, Yang J, Wang H, Xia G. 2010. Gonadotropin-regulated expressions of lanosterol 14 alpha-demethylase, sterol Delta 14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads. Prostaglandins & Other Lipid Mediators 92:25-32. Mao G, Wang J, Kang Y, Tai P, Wen J, Zou Q, Li G, Ouyang H, Xia G, Wang B. 2010. Progesterone Increases Systemic and Local Uterine Proportions of CD4(+)CD25(+) Treg Cells during Midterm Pregnancy in Mice. Endocrinology 151:5477-5488. Zhang M, Hong O, Xia G. 2009. The signal pathway of gonadotrophins-induced mammalian oocyte meiotic resumption. Molecular Human Reproduction 15:399-409. Zhang H, Xu B, Xie H, Zhou B, Ouyang H, Ning G, Li G, Zhang M, Xia G. 2009. Lanosterol Metabolic Product(s) Is Involved in Primordial Folliculogenesis and Establishment of Primordial Follicle Pool in Mouse Fetal Ovary. Molecular Reproduction And Development 76:514-521. Wen J, Zhang H, Li G, Mao G, Chen X, Wang J, Guo M, Mu X, Ouyang H, Zhang M, Xia G. 2009. PAR6, A Potential Marker for the Germ Cells Selected to Form Primordial Follicles in Mouse Ovary. Plos One 4. Wang C, Xu B, Zhou B, Zhang C, Yang J, Ouyang H, Ning G, Zhang M, Shen J, Xia G. 2009. Reducing CYP51 inhibits follicle-stimulating hormone induced resumption of mouse oocyte meiosis in vitro. Journal Of Lipid Research 50:2164-2172. Song X, Hong O, Tai P, Chen X, Xu B, Yan J, Xia G, Zhang M. 2009. Stage-specific Expression of Lanosterol 14 alpha-Demethylase in Mouse Oocytes in Relation to Fertilization and Embryo Development Competence. Asian-Australasian Journal Of Animal Sciences 22:319-327. Yang J, Fu M, Wang S, Chen X, Ning G, Xu B, Ma Y, Zhang M, Xia G. 2008. An antisense oligodeoxynucleotide to the LH receptor attenuates FSH-induced oocyte maturation in mice. Asian-Australasian Journal Of Animal Sciences 21:972-979. Yan J, Zhou B, Yang J, Tai P, Chen X, Zhang H, Zhang M, Xia G. 2008. Glucose can reverse the effects of acute fasting on mouse ovulation and oocyte maturation. Reproduction Fertility And Development 20:703-712. Xu B, Wang C, Yang J, Mao G, Zhang C, Liu D, Tai P, Zhou B, Xia G, Zhang M. 2008. Silencing of mouse hepatic lanosterol 14-alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNA. Biological & Pharmaceutical Bulletin 31:1182-1191. Tai P, Wang J, Jin H, Song X, Yan J, Kang Y, Zhao L, An X, Du X, Chen X, Wang S, Xia G, Wang B. 2008. Induction of regulatory T cells by physiological level estrogen. Journal Of Cellular Physiology 214:456-464. Song X, Tai P, Yan J, Xu B, Chen X, Hong O, Zhang M, Xia G. 2008. Expression and regulation of lanosterol 14 alpha-demethylase in mouse embryo and uterus during the peri-implantation period. Reproduction Fertility And Development 20:964-972. Ning G, Ouyang H, Wang S, Chen X, Xu B, Yang J, Zhang H, Zhang M, Xia G. 2008. 3 ',5 '-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14 alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation. Molecular Endocrinology 22:1682-1694. Chen X, Zhou B, Yan J, Xu B, Tai P, Li J, Peng S, Zhang M, Xia G. 2008. Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes. Journal Of Endocrinology 197:409-419. Zhang M, Xia G, Zhou B, Wang C. 2007. Gonadotropin-controlled mammal oocyte meiotic resumption. Frontiers In Bioscience 12:282-296. Fu M, Chen X, Yan J, Lei L, Jin S, Yang J, Song X, Zhang M, Xia G. 2007. Luteinizing hormone receptors expression in cumulus cells closely related to mouse oocyte meiotic maturation. Frontiers In Bioscience 12:1804-1813. Zhang MJ, Hong HY, Zhou B, Jin SY, Wang C, Fu MY, Wang SB, Xia GL. 2006. The expression of atrial natriuretic peptide in the oviduct and its functions in pig spermatozoa. Journal Of Endocrinology 189:493-507. Weng Q, Wang H, Medan MS, Jin W, Xia G, Watanabe G, Taya K. 2006. Expression of inhibin/activin subunits in the ovaries of fetal and neonatal mice. Journal Of Reproduction And Development 52:607-616. Wang FC, Shen Y, Song XM, Xia GL, Chen X, Zhou B, Lei L. 2006. cDNA cloning, genomic structure and expression analysis of the bovine lanosterol 14 alpha-demethylase (CYP51) in gonads. Biological & Pharmaceutical Bulletin 29:430-436. Wang C, Xie H, Song X, Ning G, Yan J, Chen X, Xu B, Hong O, Xia G. 2006. Lanosterol 14 alpha-demethylase expression in the mouse ovary and its participation in cumulus-enclosed oocyte spontaneous meiotic maturation in vitro. Theriogenology 66:1156-1164. Lei L, Zhang H, Jin S, Wang F, Fu M, Wang H, Xia G. 2006. Stage-specific germ-somatic cell interaction directs the primordial folliculogenesis in mouse fetal ovaries. Journal Of Cellular Physiology 208:640-647. Jin SY, Zhang MJ, Lei L, Wang C, Fu MY, Ning G, Xia GL. 2006. Meiosis activating sterol (MAS) regulate FSH-induced meiotic resumption of cumulus cell-enclosed porcine oocytes via PKC pathway. Molecular And Cellular Endocrinology 249:64-70. Zhenlong W, Liping X, Guoliang X, Jinfang Z, Yancheng N, Jiangchun H, Shujin W, Rongqing Z. 2005. A new tetrodotoxin-producing actinomycete, Nocardiopsis dassonvillei, isolated from the ovaries of puffer fish Fugu rubripes. Toxicon 45:851-859.2 Zhang MJ, Tao Y, Xia GL, Xie HR, Hong HY, Wang FC, Lei L. 2005. Atrial natriuretic peptide negatively regulates follicle-stimulating hormone-induced porcine oocyte maturation and cumulus expansion via cGMP-dependent protein kinase pathway. Theriogenology 64:902-916. Zhang MJ, Tang HB, Shen GC, Zhou B, Wu ZL, Peng ZX, Zhang JG, Yan J, Xia GL. 2005. Atrial natriuretic peptide induces an acrosome reaction in giant panda spermatozoa and enhances their penetration of salt-stored porcine oocytes. Theriogenology 64:1297-1308. Wu ZL, Yang Y, Xie LP, Xia GL, Hu JC, Wang SJ, Zhang RQ. 2005. Toxicity and distribution of tetrodotoxin-producing bacteria in puffer fish Fugu rubripes collected from the Bohai Sea of China. Toxicon 46:471-476. Wu ZL, Yang Y, Chen Y, Xia GL, Zhang RQ. 2005. Effects of subcutaneous administration of daidzein on blastocyst implantation in rats. Food And Chemical Toxicology 43:167-172. Wu ZL, Xie LP, Xia GL, Zhang JF, Nie YC, Hu JC, Wang SJ, Zhang RQ. 2005. A new tetrodotoxin-producing actinomycete, Nocardiopsis dassonvillei, isolated from the ovaries of puffer fish Fugu rubripes. Toxicon 45:851-859. Tao Y, Xie HR, Hong HY, Chen XF, Jang J, Xia GL. 2005. Effects of nitric oxide synthase inhibitors on porcine oocyte meiotic maturation. Zygote 13:1-9. Tao Y, Fu Z, Xia GL, Lei L, Chen XF, Yang M. 2005. Inducible nitric oxide synthase expression and luteal cell DNA fragmentation of porcine cyclic corpora lutea. Asian-Australasian Journal Of Animal Sciences 18:626-631. J.Y. Tao, Z. Fu, M.L. Zhang, G. Xia, L. Lei, Z.L. Wu (2005). "Nitric oxide influences the meiotic maturation of porcine oocytes cultured in hypoxanthine-supplemented medium." J Anim Physiol Anim Nutr (Berl) 89(1-2): 38-44. Xie HR, Xia GL, Byskov AG, Andersen CY, Bo SM, Tao Y. 2004. Roles of gonadotropins and meiosis-activating sterols in meiotic resumption of cultured follicle-enclosed mouse oocytes. Molecular And Cellular Endocrinology 218:155-163. Tao Y, Xia GL, Bo SM, Zhou B, Zhang MJ, Wang FH. 2004. Nitric oxide exerts different functions on porcine oocytes cultured in different models, which is affected by beta-mercaptoethanol. Asian-Australasian Journal Of Animal Sciences 17:317-324. Tao Y, Xia G. 2004. NO and MAPK in mouse oocytes cultured in vitro. Vyzkum v Chovu Skotu 46:58-59. Tao Y, Xia G. 2004. Inducible nitric oxide synthase expression and porcine luteal cell DNA fragmentation. Vyzkum v Chovu Skotu 46:57-58. Tao Y, Xia G. 2004. Effects of nitric oxide synthase inhibitors on porcine oocyte meiotic maturation. Vyzkum v Chovu Skotu 46:56-57. Tao Y, Fu Z, Zhang MJ, Xia GL, Yang J, Xie HR. 2004. Immunohistochemical localization of inducible and endothelial nitric oxide synthase in porcine ovaries and effects of NO on antrum formation and oocyte meiotic maturation. Molecular And Cellular Endocrinology 222:93-103. Bu SB, Xie HR, Tao Y, Wang JH, Xia GL. 2004. Nitric oxide influences the maturation of cumulus cell-enclosed mouse oocytes cultured in spontaneous maturation medium and hypoxanthine-supplemented medium through different signaling pathways. Molecular And Cellular Endocrinology 223:85-93. Bu SM, Xia GL, Tao Y, Lei L, Zhou B. 2003. Dual effects of nitric oxide on meiotic maturation of mouse cumulus cell-enclosed oocytes in vitro. Molecular And Cellular Endocrinology 207:21-30. Zhang CQ, Fang CG, Liu L, Xia GL, Qiao HL. 2002. Disrupting effects of polychlorinated biphenyls on gonadal development and reproductive functions in chickens. Journal Of Environmental Science And Health Part a-Toxic/Hazardous Substances & Environmental Engineering 37:509-519. Fang CG, Zhang CQ, Xia GL, Yang W. 2002. Damaging effects of polychlorinated biphenyls on chicken primordial germ cells. Reproduction Fertility And Development 14:177-183. Fan HY, Li MY, Tong C, Chen DY, Xia GL, Song XF, Schatten H, Sun QY. 2002. Inhibitory effects of cAMP and protein kinase C on meiotic maturation and MAP kinase phosphorylation in porcine oocytes. Molecular Reproduction And Development 63:480-487. Wang HB, Xia GL, Watanabe G, Taya K. 2001. A new simple scheme to induce superovulation in mice using inhibin antiserum. Biology Of Reproduction 64:160-160. Lu ZX, Xia GL, Zhang JC. 2001. Protein kinase C, rather than protein kinase A is involved in follicle-stimulating hormone-mediated meiotic resumption of mouse cumulus cell-enclosed oocytes in hypoxanthine-supplemented medium. Molecular And Cellular Endocrinology 182:225-232. Xia GL, Kikuchi K, Noguchi J, Izaike Y. 2000. Short time priming of pig cumulus-oocyte complexes with FSH and forskolin in the presence of hypoxanthine stimulates cumulus cells to secrete a meiosis-activating substance. Theriogenology 53:1807-1815. Lu ZX, Xia GL, Byskov AG, Andersen CY. 2000. Effects of amphotericin B and ketoconazole on mouse oocyte maturation: implications on the role of meiosis-activating sterol. Molecular And Cellular Endocrinology 164:191-196. Su YQ, Xia GL, Byskov AG, Fu CD, Yang CR. 1999. Protein kinase C and intracellular calcium are involved in follicle-stimulating hormone-mediated meiotic resumption of cumulus cell-enclosed porcine oocytes in hypoxanthine-supplemented medium. Molecular Reproduction And Development 53:51-58. Andersen CY, Ziebe S, Xia GL, Byskov AG. 1999. Requirements for human chorionic gonadotropin and recombinant human luteinizing hormone for follicular development and maturation. Journal Of Assisted Reproduction And Genetics 16:425-430. Byskov AG, Andersen CY, Hossaini A, Xia GL. 1997. Cumulus cells of oocyte-cumulus complexes secrete a meiosis-activating substance when stimulated with FSH. Molecular Reproduction And Development 46:296-305. Byskov AG, Andersen CY, Xia GL. 1995. FSH, BUT NOT LH OR HCG, STIMULATES CUMULUS CELLS TO INDUCE RESUMPTION OF MEIOSIS. Biology Of Reproduction 52:108-108. Byskov AG, Andersen CY, Nordholm L, Thogersen H, Xia GL, Wassmann O, Andersen JV, Guddal E, Roed T. 1995. Chemical-structure of sterols that activate oocyte meiosis. Nature 374:559-562. Xia GL, Byskov AG, Andersen CY. 1994. Cumulus cells secrete a meiosis-inducing substance stimulation with forskolin and dibutyric cyclic adenosine-monophosphate. Molecular Reproduction And Development 39:17-24.

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