Nirmalan, Niroshini - University of Salford - Biomedical Research Centre

个人简介

I graduated from the Faculty of Medicine, Colombo, Sri Lanka in 1991 where I was appointed Lecturer in Parasitology. Following my MSc and PhD at the University of Salford, Manchester, I did my postdoctoral training in Prof. John Hyde’s laboratory at the University of Manchester, Institute of Science and Technology (UMIST). I went on to work as a Postdoctoral Fellow at the Manchester Interdisciplinary Biocenter (MIB, University of Manchester) and my research led to the first annotated 2D proteomic maps for the malarial parasite Plasmodium falciparum and the development of a novel heavy isoleucine-based quantitative proteomic methodology to investigate the malarial proteome. I was appointed Senior Scientist at the Cancer Research UK Clinical Center at St James’s Hospital, University of Leeds in 2007, where I worked on developing a novel label-free quantitative proteomics methodology to investigate formalin-fixed tissue archives. I took up my current role as Senior Lecturer at the University of Salford in April 2010.

研究领域

Malaria continues to inflict a heavy mortality and morbidity burden globally. Drug development has struggled compete with resistance acquisition. My research interests focus on drug discovery/screening and the development of “Omics” methodology to define mechanisms of antimalarial drug action. Drug repositioning, whereby existing FDA approved drugs already used in other diseases are screened for antimalarial activity, offers a fast tracked route to discover new antimalarial options and synergistic combinatorial partners. We have screened a range of drug libraries and identified a series of compounds with antimalarial properties. Fluorescence-based in vitro drug susceptibility assays optimized in the laboratory are used in the preliminary screens. Molecular modelling and synthetic chemistry approaches are used to further refine anti-malarial efficacy and minimize non-target effects. A second research strategy focuses on the investigation of natural product options for antimalarial efficacy. A collaborative project with the National Institute for Pharmaceutical research and development (NIPRD, Nigeria) is currently exploring a series of ‘traditional fever cures’ for in vitro antimalarial activity. Potential leads are taken forward for bioassay-guided fractionation and active compound isolation.

近期论文

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Matthews, H., Hanison, J., Nirmalan, N. J. (2016) “Omics”-Informed Drug and Biomarker Discovery: Opportunities, Challenges and Future Perspectives Proteomes 4(3), 28-35. Sidhaye, A.A., Bhuran, K.C., Zambare, S., Abubaker, M., Nirmalan, N.J, Singh, K. K. (2016). Bio-inspired artemether-loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes. Nanomedicine, 11 (21), 2809-2828. Nirmalan, N.J., Nirmalan, M. (2015). Physiology of Pregnancy. In: Core Topics in Obstetric Anaesthesia , Eds. MacLennan, K., O'Brien, K., Macnab, R. ISBN: 1107028493. Matthews, H., Usman-Idris, M., Khan, F., Read, M., Nirmalan, N.J. (2013). Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate. Malaria Journal (12): 359-370. Nirmalan, N. J., Banks, R. E., Van Eyk, J. E. (2013). Proteomic analysis of formalin fixed tissues. Editorial. Proteomics: Clinical Applications (7), pp 215-216. Thomson, S. M., Craven, R. A., Nirmalan, N. J., Harnden, P., Selby, P. J., Banks, R. E. (2013). Impact of pre-analytical factors on the proteomic analysis of formalin-fixed paraffin-embedded tissue. Proteomics: Clinical Applications (7), pp 241-251. Nirmalan, N.J., Hughes, C., Peng, J., McKenna, T., Langridge, J., Cairns, D. E.,Harnden, P., Selby, P.E., Banks, R.E. (2011). Initial development and validation of a novel extraction method for quantitative mining of the formalin-fixed paraffin embedded tissue proteome for biomarker investigations, Journal of Proteome Research, 4(10), pp.896-906. .