James, Chloe - University of Salford - Biomedical Research Centre

研究领域

My chief research interests lie in bacterial pathogenicity, development and spread of antibiotic resistance and in how microbial evolution is driven by interaction with microbial communities and their environments. Specifically I have worked on molecular aspects of pathogenicity, regulation and antibiotic resistance in Escherichia coli, Porphyromonas gingivalis, Streptococcus gordonii; Enterobacter aerogenes; Pseudomonas aeruginosa; Campylobacter jejuni. I am particularly interested in Gram-negative bacteria in multi-species biofilms, and in bacteriophages. I determined that shigatoxigenic phages are able to infect a broad range of bacterial hosts. My most recent publications focus on the characterization of several temperate bacteriophages that play a role in the competitiveness of the opportunistic pathogen, Pseudomonas aeruginosa in the Cystic Fibrosis lung environment.

近期论文

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Characterisation of three active prophages from an epidemic strain of Pseudomonas aeruginosa (2012) BMC Microbiology (12) 216-28 Use of artificial sputum medium to test antibiotic efficacy against Pseudomonas aeruginosa in conditions more relevant to the cystic fibrosis lung (2012) The Journal of Visualised Experiments 64:e385 Novel therapeutic strategies to counter Pseudomonas aeruginosa infections (2012) Expert Reviews of Anti Infective Therapy (10) 219–235 The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa. (2011) Antimicrob Agents Chemother (55) 426-8 How b-Lactam Antibiotics Enter Bacteria: A Dialogue with the Porins (2009) PLoS ONE 4 (5). e5453. doi:10.1371