Meredith, David - Oxford Brookes University - Department of Biological and Medical Sciences

研究领域

The Membrane Transport Group research involves investigating the structure-function relationship of membrane transport proteins, to try to elucidate how they bind and transport their substrates. In particular, we study (nutrient) transporters that are naturally present in the intestine with a view to designing small drug molecules that can be taken up through them. These transporters include the peptide transporter (PepT1), amino acid transporters (the PAT family), monocarboxylate transporters (MCTs) and organic anion transporters (OATPs). The techniques involved range from expression of wild-type and mutated transporter proteins in model systems, cell culture, organic chemistry (with the group of Prof Pat Bailey, Keele University) and protein crystallography and molecular modelling (with Dr Newstead and Prof Samson's groups, respectively, University of Oxford).

近期论文

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Suhre, K., Shin, S.Y., Petersen, A.K., Mohney, R.P., Meredith, D., Wägele, B., Altmaier, E., CARDIoGRAM, Deloukas, P., Erdmann, J., Grundberg, E., Hammond, C.J., de Angelis, M.H., Kastenmüller, G., Köttgen, A., Kronenberg, F., Mangino, M., Meisinger, C., Meitinger, T., Mewes, H.W., Milburn, M.V., Prehn, C., Raffler, J., Ried, J.S., Römisch-Margl, W., Samani, N.J., Small, K.S., Wichmann, H.E., Zhai, G., Illig, T., Spector, T.D., Adamski, J., Soranzo, N. and Gieger, C. (2011). Human metabolic individuality in biomedical and pharmaceutical research. Nature, 477, 54-60. Pillai, S.M. and Meredith, D. (2011). SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. Journal of Biological Chemistry, 286, 2455-2460. Pieri, M., Christian, H.C., Wilkins, R.J., Boyd, C.A.R. and Meredith, D. (2010). The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase. American Journal of Physiology, 299, G136-G143. Foley, D.W., Rajamanickam, J., Bailey, P.D. and Meredith, D. (2010). Bioavailability through PepT1: the role of computer modelling in intelligent drug design. Current Computer-Aided Drug Design, 6, 68-78. Foley, D., Pieri, M., Pettecrew, R., Price, R., Miles, S., Lam, H.K., Bailey, P. and Meredith, D. (2009). The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transorter, PepT1. Organic Biomolecular Chemistry, 7, 3652-3656. Pieri, M., Gan, C., Bailey, P. and Meredith, D. (2009). The transmembrane tyrosines Y56, Y91 and Y167 play important roles in determining the affinity and transport rate of the rabbit proton-coupled peptide transporter PepT1. International Journal of Biochemistry and Cell Biology, 41, 2304-2313.