Kadhim, Munira - Oxford Brookes University - Department of Biological and Medical Sciences

个人简介

Munira's research background is in the effects of damaging agents such as chemicals and radiation on cells and tissues. She gained her first degree in Biology from Baghdad University and her PhD in Genetics from Swansea University. Before coming to Oxford Brookes University, she worked as a post-doc at Swansea University; the Weatherall Institute of Molecular Medicine, University of Oxford then moved to the Medical Research Council, Harwell where she became a research group leader for Genomic Instability (GI). Currently her research at Brookes is focused on the damaging effects of radiation on mammalian cells.

研究领域

Munira's research centres on understanding the mechanisms of early and delayed damaging responses of radiation in directly irradiated and neighbouring bystander cells/tissues and their descendents. These include primary murine and human haemopoietic stem cells, lymphocytes, fibroblasts and cancer cells. This research is focused on investigating factors which influence these damages such as radiation type, dose and genetic background as well as identifying the nature of communication molecules involved in these responses. These investigations are carried out using several cellular and molecular approaches such as chromosome analysis for chromosome damage, general and specific DNA damage and advanced techniques for cellular signalling.

近期论文

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Kadhim, M., Salomma,S., Wright,E., Hildebrandt,G., Belyakov,O., Prise,K., Little,M. (2013) Non-targeted effects of ionizing radiation- Implication for low dose risk, Mutation Research Review doi:pii: S1383-5742(12)00066-X. 10.1016/j.mrrev.2012.12.001. 752: 84-98 Klammer, H., Zhang, L., Kadhim, M. and Iliakis, G. (2012) Dependence of adaptive response and its bystander transmission on the genetic background of tested cells IJRB 88 (10): 720-726 Irons, SL. Serra, V., Bowler, D.A., Chapman, K.L., Militi, S., Lyng, F. and Kadhim, M.A. (2012) The effect of genetic background and dose on non-targeted effects of radiation IJRB 88 (10): 735-742 Chapman, KL. Al-Mayah, A.H., Bowler, D.A., Irons, S.L. and Kadhim, M.A. (2012) No influence of serotonin levels in foetal bovine sera on radiation induced bystander effects and genomic instability, IJRB 88 (10): 781-785 Al-Mayah, A.H., Irons, S.L., Pink, R.C., Carter, D.R., Kadhim, M.A. (2012) Possible role of Exosomes Containing RNA in mediating Non-Targeted Effect of Ionizing Radiation. Radiation Research 177: 539-545. Schilling-Tóth, B., Sándor, N., Kis, E., Kadhim, M., Sáfrány, G. and Hegyesi, H. (2011) Analysis of the common deletions in the mitochondrial DNA is a sensitive biomarker detecting direct and non-targeted cellular effects of low dose ionizing radiation, Mutation Research 716 (1-2), pp 33, DOI:10.1016/j.mrfmmm.2011.07.018 Klammer, H., Kadhim, M. and Iliakis, G (2010) Evidence of an adaptive response targeting DNA nonhomologous endjoining and its transmission to bystander cells Cancer Research 70(21) pp8498 DOI:10.1158/0008-5472.CAN-10-1181