Reithofer, Michael - University of Hull

个人简介

Michael Reithofer studied Chemistry at the University of Vienna (winning an Award of Academic Excellence every year from the University) where he graduated with a Magistra rerum naturalium (Mag.rer.nat.; equivalent to an MChem) in 2005. Michael stayed in Vienna to pursue his post graduate studies with Prof. Dr. Dr. Bernhard Keppler where he worked on novel platinum(IV) anticancer compounds. This work was recognized with an Award of Excellence for Outstanding Ph.D. Research by the Austrian Federal Ministry of Science and Research. Following his graduation as Dr.rer.nat, Michael received the prestigious Erwin Schrödinger Fellowship from the Austrian Science Fund (FWF) which enabled him to work together with the Nobel Prize Laureate Prof. Richard Schrock at the Massachusetts Institute of Technology (MIT) on the development of novel metathesis catalysts, leading to a patent with Professor Schrock.. He also worked on dinitrogen activation on novel molybdenum complexes. Thereafter, Michael joined the Institute of Bioengineering and Nanotechnology, an A*STAR research institute in Singapore where he worked on carbon dioxide activation and on self-assembling ultrashort peptides for drug delivery. Michael joined the Department of Chemistry at the University of Hull in November 2014.

研究领域

Biological Chemistry

Our research utilizes synthetic chemistry to address important health care problems. We are interested in studying peptide-based materials as drug delivery agents, especially in anti-cancer therapy. We are also interested in utilizing peptidic materials as templates for nanostructures. My group is actively seeking PhD students for multiple projects and self-funded students are strongly encouraged to contact me.

近期论文

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Tan, T.T. Y.; Cham, J. T. M.; Reithofer, M. R.; Hor, T. S. A.; Chin, J. M. "Motorized Janus metal organic framework crystals", Chem. Commun., 2014, 50, 15175 Reithofer, M. R.; Lakshmanan, A.; Tay, K. P. A.; Chin, J. M.; Hauser, C. A. E. "In situ Synthesis of Size-controlled, Stable Silver Nanoparticles within Ultrashort Peptide Hydrogels for Effective Anti-bacterial Therapy", Biomaterials, 2014, 35, 7537-7542. Tan, T.T. Y.; Ahsan, A.; Reithofer, M. R.; Tay, S. W.; Tan, S. Y.; Xu, J.; Hor, T. S. A.; Chin, J. M.; Chew, B. K. J.; Wang, X. B. "Photoresponsive Liquid Marbles and Dry Liquids", Langmuir, 2014, 30, 3448-3454. Reithofer, M. R.*; Chan, K.-H.; Lakshmanan, A.; Lam, D. H.; Mishra, A.; Gopalan, B.; Joshi, M.; Wang, S.; Hauser, C. A. E.* "Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy", Chem. Sci., 2014, 5, 625-630. (*corresponding author), #Featured as HOT paper by Chemical Science. The above paper was highlighted on Nanowerk and A*STAR Research http://www.nanowerk.com/nanotechnology-news/newsid=35880.php http://www.research.a-star.edu.sg/research/6977 Tan, T. T. Y; Reithofer, M. R.; Chen, E.; Menon, A.; Hor, T. S. A.; Xu, J.; Chin, J. M. "Tuning Omniphobicity via Morphological Control of Metal-Organic Framework Functionalized Surfaces", J. Am. Chem. Soc., 2013, 135, 16272-16275. The above paper was highlighted on Nanowerk, USANews and A*STAR Research http://www.nanowerk.com/nanotechnology_news/newsid=35135.php https://www.research.a-star.edu.sg/research/6955 http://www.dailynewsen.com/science/chemical-transformation-yields-surface-bound -microstructures-that-repel-oil-and-water-based-contaminants-h2468799.html Reithofer, M. R.; Sum, Y. N.; Zhang, Y. "Synthesis of Cyclic Carbonates with Carbon Dioxide and Cesium Carbonate", Green Chem., 2013, 15, 2086-2090. Reithofer, M. R.; Dobereiner, G. E.; Schrock, R. R.; Müller, P. "Monoaryloxide Pyrrolide (MAP) Imido Alkylidene Complexes of Molybdenum and Tungsten That Contain 2,6-Bis(2,5- R2-pyrrolyl)phenoxide (R = i-Pr, Ph) Ligands and an Unsubstituted Metallacyclobutane on Its Way to Losing Ethylene", Organometallics, 2013, 32, 2489-2492. Mishra, A.; Chan, K.-H.; Reithofer, M. R.; Hauser, C. A. E. "Influence of metal salts on the hydrogelation properties of ultrashort aliphatic peptides", RSC Advances, 2013, 3, 9985-9993. Chin, J. M.; Reithofer, M. R.; Tan, T. T. Y.; Menon, A. G.; Chen, E. Y.; Chow, C. A.; Hor, A. T. S.; Xu, J. "Supergluing MOF liquid marbles", Chem. Commun., 2013, 49, 493-495. The above paper was highlighted on ScienceDaily, Phys.org and Nanowerk http://www.nanowerk.com/news2/newsid=31613.php http://www.sciencedaily.com/releases/2013/07/130731152017.htm http://phys.org/news/2013-07-smart-materials-fused-liquid-marbles.html Buss, I.; Kalayda, G. V.; Lindauer, A.; Reithofer, M. R.; Galanski, M.; Keppler, B. K.; Jaehde, U. "Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues," J. Biol. Inorg. Chem., 2012, 17, 699-708. Ginzinger, W.; Muehlgassner, G.; Arion, V. B.; Jakupec, M. A.; Roller, A.; Galanski, M.; Reithofer, M.; Berger, W.; Keppler, B. K. "A SAR study of novel antiproliferative ruthenium and osmium complexes with quinoxalinone ligands in human cancer cell lines", J. Med. Chem., 2012, 55, 3398-3413. Reithofer, M. R.; Bytzek, A. K.; Valiahdi, S. M.; Kowol, C. R.; Groessl, M.; Hartinger, C. G.; Jakupec, M. A.; Galanski, M.; Keppler, B. K. "Tuning of Lipophilicity and Cytotoxic Potency by Structural Variation of Anticancer Platinum(IV) Complexes", J. Inorg. Biochem, 2011, 105, 46-51. Reithofer, M. R.; Schrock, R. R.; Müller; P. "Synthesis of [(DPPNCH2CH2N)3N]3− Molybdenum Complexes (DPP = 3,5-(2,5-diisopropylpyrrolyl)2C6H3) and Studies Relevant to Catalytic Reduction of Dinitrogen", J. Am. Chem. Soc., 2010, 132, 8349-8358. Bytzek, A. K.; Reithofer, M. R.; Galanski, M.; Groessl, M.; Keppler, B. K.; Hartinger C. G. "The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes", Electrophoresis, 2009, 31, 1144-1150. Reithofer, M. R.*; Schwarzinger, A.; Valiahdi, S. M.; Galanski, M.; Jakupec, M. A.; Keppler, B. K. "Novel dicarboxylatodichlorido(ethan-1,2-diamine)platinum(IV) complexes with exceptionally high cytotoxicity", J. Inorg. Biochem, 2008, 102, 2072-2077, (*corresponding author). Reithofer, M. R.; Valiahdi, S. M.; Galanski, M.; Jakupec, M. A.; Arion, V. B.; Keppler, B. K. "Novel endothall containing platinum(IV) complexes - synthesis, characterization, and cytotoxic activity", Chem. Biodiv., 2008, 5, 2160-2170, (ICBIC 13 special issue). Valiahdi, S. M.; Reithofer, M. R.; Egger, A.; Jakupec, M. A.; Galanski, M.; Keppler, B. K. "Structure-activity relationships and DNA platination of new di- and tetra-carboxylatoplatinum(IV) complexes", Met. Ions Biol. Med., 2008,10, 75-81.