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个人简介

2008年获武汉大学化学系学士学位,2011年获Iowa State University化学系硕士学位,2017年获Columbia University化学系博士学位。2017-2019年于哥伦比亚大学化学系任博士后,2020年起任清华大学化学系副教授。研究兴趣为发展分子光谱,化学探针和非线性光学成像技术,及其在细胞活动、药物作用机制和疾病诊断中的应用。获得2016年国家优秀自费留学生奖学金特别优秀奖,2017年哥伦比亚大学化学系Hammett Award,和2019年国家海外高层次人才引进计划青年项目资助。

研究领域

非线性光学显微成像 分子光谱和化学探针 亚细胞水平互作和细胞异质性

近期论文

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Y. Yang, X. Bai, F. Hu*, Photoswitchable polyynes for multiplexed stimulated Raman scattering microscopy with reversible light control, Nat. Commun., 15, 2578 (2024).34.pdf A. N. von Krusenstiern, R. N. Robson, N. Qian, B. Qiu, F. Hu, E. Reznik, N. Smith, F. Zandkarimi, V. M. Estes, M. Dupont, T. Hirschhorn, M. S. Shchepinov, W. Min*, K. A. Woerpel*, B. R. Stockwell*, Identification of essential sites of lipid peroxidation in ferroptosis, Nat. Chem. Biol., 19, 719 (2023).33.pdf J. Shou, R. Oda, F. Hu*, K. Karasawa, M. Nuriya, M. Yasui, B. Shiramizu, W. Min*, Y. Ozeki*, Super-multiplex imaging of cellular dynamics and heterogeneity by integrated stimulated Raman and fluorescence microscopy, iScience, 24, 102832 (2021).32.pdf Y. Miao, N. Qian, L. Shi, F. Hu, W. Min*, 9-Cyanopyronin probe palette for super-multiplexed vibrational imaging, Nat. Commun., 12, 4518 (2021).31.pdf C. Chen, Z. Zhao, N. Qian, S. Wei, F. Hu, and W. Min*, Multiplexed live-cell profiling with Raman probes, Nat. Commun., 12, 3405 (2021).30.pdf Z. Zhao, C. Chen, S. Wei, H. Xiong, F. Hu, Y. Miao, T. Jin, and W. Min*, Ultra-bright Raman dots for multiplexed optical imaging, Nat. Commun., 12, 1305 (2021).29.pdf L. Shi, F. Hu, and W. Min*, Optical mapping of biological water in single live cells by stimulated Raman excited fluorescence microscopy, Nat. Commun., 10, 4764 (2019). F. Hu#, L. Shi#, and W. Min*, Biological imaging of chemical bonds by stimulated Raman scattering microscopy,Nat. Methods, 16, 830-842 (2019). (# equal contribution) J. Seidel, Y. Miao, W. Porterfield, W. Cai, X. Zhu, S. Kim, F. Hu, S. Bhattarai-Kline, W. Min*, W. Zhang*, Structure–activity–distribution relationship study of anti-cancer antimycin-type depsipeptides, Chem. Commun., 55, 9379-9382 (2019). Y. Miao, L. Shi, F. Hu, and W. Min*, Probe design for super-multiplexed vibrational imaging, Phys. Biol., 16, 041003 (2019). Y. Shen, F. Hu, and W. Min*, Raman imaging of small biomolecules, Annu. Rev. Biophys., 48, 347-369 (2019). K. T. Schiessl#, F. Hu#, J. Jo, S. Z. Nazia, B. Wang, A. Price-Whelan, W. Min* and L. E. P. Dietrich*, Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms, Nat. Commun., 10, 762 (2019). (# equal contribution) C. Zeng, F. Hu, R. Long, and W. Min*, A ratiometric Raman probe for live-cell imaging of hydrogen sulfide in mitochondria by stimulated Raman scattering, Analyst, 143, 4844-4848 (2018). M. M. Gaschler, F. Hu, H. Feng, A. Linkermann, W. Min*, and B. R. Stockwell*, Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis, ACS Chem. Biol., 13, 1013-1020 (2018). F. Hu#, C. Zeng#, R. Long, Y. Miao, L. Wei, Q. Xu, and W. Min*, Supermultiplexed optical imaging and barcoding with engineered polyynes, Nat. Methods, 15, 194-200 (2018). (# equal contribution) R. Long, L. Zhang, L. Shi, Y. Shen, F. Hu, C. Zeng and W. Min*, Two-color vibrational imaging of glucose metabolism using stimulated Raman scattering, Chem. Commun., 54, 152-155 (2018). Z. Zhao, Y. Shen, F. Hu, and W. Min*, Applications of vibrational tags in biological imaging by Raman microscopy, Analyst, 142, 4018-4029 (2017). F. Hu#, S. D. Brucks#, T. H. Lambert, L. M. Campos* and W. Min*, Stimulated Raman scattering of polymer nanoparticles for multiplexed live-cell imaging, Chem. Commun., 53, 6187-6190 (2017). (# equal contribution) L. Wei, Z. Chen, L. Shi, R. Long, A. V. Anzalone, L. Zhang, F. Hu, R. Yuste, V. W. Cornish and W. Min*, Super-multiplex vibrational imaging, Nature, 544, 465-470 (2017). F. Hu, M. Lamprecht, L. Wei, B. Morrison* and W. Min*, Bioorthogonal chemical imaging of metabolic activities in live mammalian hippocampal tissues with stimulated Raman scattering, Sci. Rep., 6, 39660, (2016). L. Wei, F. Hu, Z. Chen, Y. Shen, L. Zhang and W. Min*, Live-cell bioorthogonal chemical imaging: stimulated Raman scattering microscopy of vibrational probes, Acc. Chem. Res., 49, 1494-1502 (2016). K. Mishiro, F. Hu, D. W. Paley, W. Min, T. H. Lambert*, Macrosteres: the deltic guanidinium ion, Eur. J. Org. Chem., 2016, 1655-1659 (2016). F. Hu, Z. Chen, L. Zhang, Y. Shen, L. Wei and W. Min*, Vibrational imaging of glucose uptake activity in live cells and tissues by stimulated Raman scattering, Angew. Chem. Int. Ed., 54, 9821-9825 (2015). L. Wei, Y. Shen, F. Xu, F. Hu, J. Harrington, K. Targoff and W. Min*, Imaging complex protein metabolism in live organisms by stimulated Raman scattering microscopy with isotope labeling, ACS Chem. Biol., 10, 901-908 (2015). Y. Shen, F. Xu, L. Wei, F. Hu and W. Min*, Live-cell quantitative imaging of proteome degradation by stimulated Raman scattering, Angew. Chem. Int. Ed., 53, 5596-5599 (2014). L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C.-C. Lin, M. Wang and W. Min*, Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering, Nat. Methods, 11, 410-412 (2014). F. Hu, L. Wei, C. Zheng, Y. Shen and W. Min*, Live cell vibrational imaging of choline metabolites by stimulated Raman scattering coupled with isotope-based metabolic labeling, Analyst, 139, 2312-2317 (2014). Y. Su, F. Hu and M. Hong*, Paramagnetic Cu(II) for probing membrane protein structure and function: inhibition mechanism of the influenza M2 proton channel, J. Am. Chem. Soc., 134, 8693-8702 (2012). M. Hong*, Y. Zhang and F. Hu, Membrane protein structure and dynamics from NMR spectroscopy, Annu. Rev. Phys. Chem., 63, 1-24 (2012). F. Hu, K. Schmidt-Rohr and M. Hong*, NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel, J. Am. Chem. Soc., 134, 3703-3713 (2012). J. Wang, C. Ma, G. Fiorin, V. Carnevale, T. Wang, F. Hu, R. A. Lamb, L. H. Pinto, M. Hong, M. L. Klein*, and W. F. DeGrado*, Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2, J. Am. Chem. Soc., 133, 12834-12841 (2011). F. Hu, W. Luo, S. D. Cady and M. Hong*, Conformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding and membrane thickness, Biochim. Biophys. Acta Biomembranes, 1808, 415-423 (2011). F. Hu, W. Luo, and M. Hong*, Mechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMR, Science, 330, 505-508 (2010). S. D. Cady, W. Luo, F. Hu, and M. Hong*, Structure and function of the influenza M2 proton channel, Biochemistry, 48, 7356-7364 (2009).

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