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1. Jing Ren, Yang He, Wuyan Chen, Tiantian Chen, Guan Wang, Zhen Wang, Zhijian Xu, Xiaomin Luo, Weiliang Zhu, Hualiang Jiang, Jingshan Shen*, and Yechun Xu*. Thermodynamic and Structural Characterization of Halogen Bonding in Protein-ligand Interactions: A Case Study of PDE5 and Its Inhibitors. J. Med. Chem. 2014, 57, 3588-3593.
2. Ida Fejos, Yang He, Gergely Volgyi, Adrienn Kazsoki, Jin Sun, Weiming Chen, Tamas Sohajda, Lajos Szente, Xiangrui Jiang*, Szabolcs Beni*. Tapentadol enantiomers: Synthesis, physico-chemical characterization and cyclodextrin interactions. J. Pharm. Biomed. 2014, 88, 594-601.
3. Zhen Wang, Difeng Zhu, Xiaochun Yang, Jianfeng Li, Xiangrui Jiang, Guanghui Tian, Nicholas Kenneth Terrett, Jie Jin, Honghai Wu, Qiaojun He, Bo Yang, Jingshan Shen. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J. Sex. Med. 2013, 10 (11), 2790-2797.
4. Xudong Gong, Guan Wang, Jing Ren, Zheng Liu, Zhen Wang, Tiantian Chen, Xiaojun Yang, Xiangrui Jiang, Jingshan Shen, Hualiang Jiang, Haji Akber Aisa, Yechun Xu, Jianfeng Li. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg. Med. Chem. Lett. 2013, 23, 4944-4947.
5. Yongjun Mao, Wenxiu Zhu, Xiaoguang Kong, Zhen Wang, Hua Xie, Jian Ding, Nicholas Kenneth Terrett, Jingkang Shen, Jingshan Shen. Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors. Bioorg. Med. Chem. 2013, 21, 3090-3104.
6. Guan Wang, Zheng Liu, Tiantian Chen, Zhen Wang, Huaiyu Yang, Mingyue Zheng, Jing Ren, Guanghui Tian, Xiaojun Yang, Li Li, Jianfeng Li, Jin Suo, Rongxia Zhang, Xiangrui Jiang, Nicholas Kenneth Terrett, Jingshan Shen*, Yechun Xu*, Hualiang Jiang*. Design, Synthesis, and Pharmacological Evaluation of Monocyclic Pyrimidinones as Novel Inhibitors of PDE5. J. Med. Chem. 2012, 55 (23), 10540-10550.
7. Yongjun Mao, Zheng Liu, Xiaojun Yang, Xiangfei Xia, Rongxia Zhang, Jianfeng Li, Xiangrui Jiang, Kai Xie, Jin Zheng, Hui Zhang, Jin Suo, Jingshan Shen*. A New and Improved Process for N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide. Org. Process Res. Dev. 2012, 16 (12), 1970-1973.
8. Qiang Zhang, Jian-Feng Li, Guang-Hui Tian, Rong-Xia Zhang, Jin Sun, Jin Suo, Xin Feng, Du Fang, Xiang-Rui Jiang*, Jing-Shan Shen. A Practical and Enantioselective Synthesis of Tapentadol. Tetrahedron: Asymmetry. 2012, 23, 577-582.
9. Zhijian Xu, Zheng Liu, Tong Chen, TianTian Chen, Zhen Wang, Guanghui Tian, Jing Shi, Xuelan Wang, Yunxiang Lu, Xiuhua Yan, Guan Wang, Hualiang Jiang, Kaixian Chen, Shudong Wang, Yechun Xu, Jingshan Shen*, and Weiliang Zhu*. Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. J. Med. Chem. 2011, 54 (15), 5607-5611.
10. Zhi Chen, Guanghui Tian, Zhen Wang, Hualiang Jiang, Jingshan Shen*, Weiliang Zhu*. Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity. J. Chem. Inf. Model. 2010, 50 (4), 615-625.
11. Yongjun Mao, Guanghui Tian, Zheng Liu, Jingkang Shen, Jingshan Shen*. An Improved Synthetic Route for Preparative Process of Vardenafil. Org. Process Res. Dev. 2009, 13 (6), 1206-1208.
12. Xiangrui Jiang, Jianfeng Li, Rongxia Zhang, Hongli Guo, Shaolei Huang, Jingshan Shen*. Improved Preparation of 3-(1,1-Dimethylallyl)decursinol. J. Heterocycl. Chem. 2009, 46, 560-562.
13. Hongliang Duan, Jin Zheng, Qinglin Lai, Zheng Liu, Guanghui Tian, Zhen Wang, Jianfeng Li, Jingshan Shen*. 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6. Bioorg. Med. Chem. Lett. 2009, 19 (10), 2777-2779.
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