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个人简介

2005年在中国科学院上海药物研究所获得有机化学博士学位。2005-2006年在美国犹他大学从事博士后研究,2006-2010年在美国马里兰大学任研究助理,2010-2012年在美国马里兰大学任助理教授。2012年受聘于上海药物研究所,担任课题组长。2020年兼任国科大杭州高等研究院药物科学与技术学院执行院长。 工作经历 2002.09.01 - 2005.07.01 有机化学博士,中国科学院上海药物研究所 1999.09.01 - 2002.07.01 药物化学硕士,沈阳药科大学 1995.09.01 - 1999.07.01 制药工程学士,沈阳药科大学

研究领域

1.单克隆抗体药物的糖基化改造与抗体药物偶联物(ADC)的研发 2.复杂天然产物糖修饰策略与新型糖结构药物研发 3.药物受体糖基化结构与功能及靶向糖基化干预策略 4.细胞表面糖链标记、成像与膜受体糖链功能研究

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Hao Wang, Zhongyu Li, Xiangyang Chen, Jonathan J. Wong, 毕童钰, Xiankun Tong, Zhongliang Xu, 郑明月, Yunhui Wan, Li Tang, Bo Liu, Xinlei Zong, Xu, Dandan, Zuo JianPing, Li Yang, 黄蔚, Kendall N. Houk, Weibo Yang. Multicomponent coupling and macrocyclization enabled by Rh(III)-catalyzed dual C-H activation: macrocyclic oxime inhibitor of influenza H1N1. Chem[J]. 2023, 9: 1-17, Zou, Xiangman, Liu, Zhi, Liu, Liya, Shi, Wei, Li, Wanzhen, Guo, Zifen, Tang, Feng, Huang, Wei. Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2022, 20(15): 3086-3095, Long, Yiru, Sun, Jianhua, Song, TianZhang, Liu, Tingting, Tang, Feng, Zhang, Xinxin, Ding, Longfei, Miao, Yunqiu, Zhu, Weiliang, Pan, Xiaoyan, An, Qi, Qin, Mian, Tong, Xiankun, Peng, Xionghua, Yu, Pan, Zhu, Peng, Xu, Jianqing, Zhang, Xiaoyan, Zhang, Yachun, Liu, Datao, Chen, Ben, Chen, Huilin, Zhang, Leike, Xiao, Gengfu, Zuo, Jianping, Tang, Wei, Zhou, Ji, Li, Heng, Xu, Zhijian, Zheng, HongYi, Long, XinYan, Qin, Qiuping, Gan, Yong, Ren, Jin, Huang, Wei, Zheng, YongTang, Jin, Guangyi, Gong, Likun. CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity. CELL DISCOVERY[J]. 2022, 8(1): Zeng, Yue, Shi, Wei, Dong, Qian, Li, Wanzhen, Zhang, Jianxin, Ren, Xuelian, Tang, Caihong, Liu, Bo, Song, Yuanli, Wu, Yali, Diao, Xingxing, Zhou, Hu, Huang, He, Tang, Feng, Huang, Wei. A Traceless Site-Specific Conjugation on Native Antibodies Enables Efficient One-Step Payload Assembly. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, Lei, E, Tao, Huanyu, Jiao, Shang, Yang, Anming, Zhou, Yu, Wang, Min, Wen, Kang, Wang, Yi, Chen, Zhiyong, Chen, Xianhui, Song, Junfeng, Zhou, Cailing, Huang, Wei, Xu, Lili, Guan, Dongliang, Tan, Cuiyan, Liu, Haoran, Cai, Qingyun, Zhou, Kai, Modica, Justin, Huang, ShengYou, Huang, Wei, Feng, Xinxin. Potentiation of Vancomycin: Creating Cooperative Membrane Lysis through a "Derivatization-for-Sensitization" Approach. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144(23): 10622-10639, http://dx.doi.org/10.1021/jacs.2c03784. Chen, Yao, Tang, Feng, Qin, Hongqiang, Yue, Xuyang, Nie, Yongzhan, Huang, Wei, Ye, Mingliang. Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, Zeng, Yue, Tang, Feng, Shi, Wei, Dong, Qian, Huang, Wei. Recent advances in synthetic glycoengineering for biological applications. CURRENT OPINION IN BIOTECHNOLOGY[J]. 2022, 74: 247-255, Shi, Wei, Li, Wanzhen, Zhang, Jianxin, Li, Tiehai, Song, Yakai, Zeng, Yue, Dong, Qian, Lin, Zeng, Gong, Likun, Fan, Shuquan, Tang, Feng, Huang, Wei. One-step synthesis of site-specific antibody-drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates. ACTA PHARMACEUTICA SINICA B[J]. 2022, 12(5): 2417-2428, Li, Jian, Guan, Dongliang, Chen, Feifei, Shi, Weiwei, Lan, Lefu, Huang, Wei. Total and Semisyntheses of Polymyxin Analogues with 2-Thr or 10-Thr Modifications to Decipher the Structure-Activity Relationship and Improve the Antibacterial Activity. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(9): 5746-5765, Li, Jian, Zhu, Yue, Liu, Bo, Tang, Feng, Zheng, Xing, Huang, Wei. An Atom-Economic Inverse Solid-Phase Peptide Synthesis Using Bn or BcM Esters of Amino Acids. ORGANIC LETTERS[J]. 2021, 23(19): 7571-7574, Wang, Siqi, Miao, Erfei, Wang, Hao, Song, Bichao, Huang, Wei, Yang, Weibo. Rh-Catalyzed cascade C-H activation/C-C cleavage/cyclization of carboxylic acids with cyclopropanols. CHEMICAL COMMUNICATIONS[J]. 2021, 57(48): 5929-5932, Shi, Weiwei, Chen, Feifei, Zou, Xiangman, Jiao, Shang, Wang, Siqi, Hu, Yu, Lan, Lefu, Tang, Feng, Huang, Wei. Design, synthesis, and antibacterial evaluation of vancomycin-LPS binding peptide conjugates. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2021, 45: Song, Yakai, Deng, Xiaojie, Shi, Wei, Tang, Feng, Huang, Wei, Gong, Likun, Qin, Qiuping. A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies. JOURNAL OF IMMUNOLOGICAL METHODS[J]. 2021, 499: Pan, Deng, Tang, Yubo, Tong, Jiao, Xie, Chengmei, Chen, Jiaxi, Feng, Chunchao, Hwu, Patrick, Huang, Wei, Zhou, Dapeng. An antibody-drug conjugate targeting a GSTA glycosite-signature epitope of MUC1 expressed by non-small cell lung cancer. CANCER MEDICINE[J]. 2020, 9(24): 9529-9540, Liu, Yichu, Wang, Yibing, Dai, Wenhao, Huang, Wei, Li, Yingxia, Liu, Hong. Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(9): 3491-3494, Shi, Wei, Tang, Feng, Ao, Jiwei, Yu, Qun, Liu, Junjie, Tang, Yubo, Jiang, Bofeng, Ren, Xuelian, Huang, He, Yang, Weibo, Huang, Wei. Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(45): 19940-19944, Lu, Dan, Yin, Hongli, Wang, Siyao, Tang, Feng, Huang, Wei, Wang, Ping. Chemical Synthesis of the Homogeneous Granulocyte-Macrophage Colony-Stimulating Factor Through Se-Auxiliary-Mediated Ligation. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 85(3): 1652-1660, Tang, Feng, Zhou, Mang, Qin, Ken, Shi, Wei, Yashinov, Ansor, Yang, Yang, Yang, Liyun, Guan, Dongliang, Zhao, Lei, Tang, Yubo, Chang, Yujie, Zhao, Lifen, Yang, Huaiyu, Zhou, Hu, Huang, Ruimin, Huang, Wei. Selective N-glycan editing on living cell surfaces to probe glycoconjugate function. NATURE CHEMICAL BIOLOGY[J]. 2020, 16(7): 766-+, Ming Li, Yaqiang Bai, Jiaorui Zhou, Wei Huang, Jingyu Yan, Jia Tao, Qingjie Fan, Yang Liu, Di Mei, Qiulong Yan, Jieli Yuan, Patrice Malard, Zhongfu Wang, Jianguo Gu, Naoyuki Tanigchi, Wenzhe Li. Core Fucosylation of Maternal Milk N-Glycan Evokes B Cell Activation by Selectively Promoting the l-Fucose Metabolism of Gut Bifidobacterium spp. and Lactobacillus spp.. mBio[J]. 2019, 10(2): IR_Article. Faridoon, Shi, Wei, Qin, Ken, Tang, Yubo, Li, Mingjie, Guan, Dongliang, Tian, Xiaobo, Jiang, Bofeng, Dong, Jinhua, Tang, Feng, Huang, Wei. New linker structures applied in glycosite-specific antibody drug conjugates. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(17): 3144-3149,

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