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Hao Jiang, Shijia Zu, Yu Lu, Zhongya Sun, Akejiang Adeerjiang, Qiao Guo, Huimin Zhang, Chen Dong, Qiqi Wu, Hong Ding, Daohai Du, Mingliang Wang, Chuanpeng Liu, Yong Tang, Zhongjie Liang, Cheng Luo. A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region. JOURNAL OF STRUCTURAL BIOLOGY. 2023, 215(2): http://dx.doi.org/10.1016/j.jsb.2023.107942.
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang. Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2023, 8(1): 1-16, http://dx.doi.org/10.1038/s41392-022-01231-4.
Xiao, Senhao, Guo, Siqi, Han, Jie, Sun, Yanli, Wang, Mingchen, Chen, Yantao, Fang, Xueyu, Yang, Feng, Mu, Yajuan, Zhang, Liang, Ding, Yiluan, Zhang, Naixia, Jiang, Hualiang, Chen, Kaixian, Zhao, Kehao, Luo, Cheng, Chen, Shijie. High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(2): http://dx.doi.org/10.1093/nar/gkab989.
Liu, Tonghai, Shi, Wenjia, Ding, Yiluan, Wu, Qiqi, Zhang, Bei, Zhang, Naixia, Wang, Mingliang, Du, Daohai, Zhang, Hao, Han, Bo, Guo, Dean, Zheng, Jie, Li, Qi, Luo, Cheng. (-)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase. ACS MEDICINAL CHEMISTRY LETTERS. 2022,
Lei, Yixuan, Fei, Panyu, Song, Bin, Shi, Wenjia, Luo, Cheng, Luo, Dahai, Li, Dan, Chen, Wei, Zheng, Jie. A loosened gating mechanism of RIG-I leads to autoimmune disorders. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(10): 5850-5863, http://dx.doi.org/10.1093/nar/gkac361.
Liao Liping, Dang Wenzhen, Lin Tingting, Yu Jinghua, Liu Tonghai, Li Wen, Xiao Senhao, Feng Lei, Huang Jing, Fu Rong, Li Jiacheng, Liu Liping, Wang Mingchen, Tao Hongru, Jiang Hualiang, Chen Kaixian, Diao Xingxing, Zhou Bing, Shen Xiaoyan, Luo Cheng. A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1b and IL-6. ACTA PHARMACEUTICA SINICA B[J]. 2022, 12(11): 4180-4192, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7343049&detailType=1.
Huang, Jing, Wang, Xiaobo, Li, Bing, Shen, Shiyu, Wang, Ruina, Tao, Hongru, Hu, Junchi, Yu, Jin, Jiang, Hualiang, Chen, Kaixian, Luo, Cheng, Dang, Yongjun, Zhang, Yuanyuan. L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression. JOURNAL FOR IMMUNOTHERAPY OF CANCER[J]. 2022, 10(6): https://doaj.org/article/417fb981fcae4ac29843cc2102fbc22e.
Liping Liao, Wenzhen Dang, Tingting Lin, Jinghua Yu, Tonghai Liu, Wen Li, Senhao Xiao, Lei Feng, Jing Huang, Rong Fu, Jiacheng Li, Liping Liu, Mingchen Wang, Hongru Tao, Hualiang Jiang, Kaixian Chen, Xingxing Diao, Bing Zhou, Xiaoyan Shen, Cheng Luo. A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6. ACTA PHARMACEUTICA SINICA B[J]. 2022, 12(11): 4180-4192, http://dx.doi.org/10.1016/j.apsb.2022.05.012.
Mao, Jianhua, Zhu, Kongkai, Long, Zhangbiao, Zhang, Huimin, Xiao, Bing, Xi, Wenda, Wang, Yun, Huang, Jiansong, Liu, Jingqiu, Shi, Xiaofeng, Jiang, Hao, Lu, Tian, Wen, Yi, Zhang, Naixia, Meng, Qian, Zhou, Hu, Ruan, Zheng, Wang, Jin, Luo, Cheng, Xi, Xiaodong. Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis. ADVANCED SCIENCE[J]. 2022, 9(7): http://dx.doi.org/10.1002/advs.202103228.
Liu, Liping, Zhu, Rui, Li, Jiacheng, Pei, Yuan, Wang, Shuangshuang, Xu, Pan, Wang, Mingyu, Wen, Yu, Zhang, Hao, Du, Daohai, Ding, Hong, Jiang, Hualiang, Chen, Kaixian, Zhou, Bing, Yu, Lifang, Luo, Cheng. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 65(3): 2174-2190, http://dx.doi.org/10.1021/acs.jmedchem.1c01686.
Fu, Rong, Zu, ShiJia, Liu, YanJun, Li, JiaCheng, Dang, WenZhen, Liao, LiPing, Liu, LiPing, Chen, PanYu, Huang, HeMing, Wu, KangHui, Zhou, Bing, Pan, Qin, Luo, Cheng, Zhang, YuanYuan, Li, GuangMing. Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis. BIOENGINEERED[J]. 2022, 13(4): 10914-10930, http://dx.doi.org/10.1080/21655979.2022.2066756.
Yang, Fan, Sun, Rui, Hou, Zeng, Zhang, FangLin, Xiao, Yi, Yang, YunSong, Yang, ShaoYing, Xie, YiFan, Liu, YingYing, Luo, Cheng, Liu, GuangYu, Shao, ZhiMin, Li, DaQiang. HSP90 N-terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2-driven breast cancer progression. CLINICAL AND TRANSLATIONAL MEDICINE[J]. 2022, 12(5): http://dx.doi.org/10.1002/ctm2.825.
Wang, Yang, Yuan, Wenjie, Guo, Siqi, Li, Qiqi, Chen, Xiaomei, Li, Cheng, Liu, Qianying, Sun, Lei, Chen, Zhenguo, Yuan, Zhenghong, Luo, Cheng, Chen, Shijie, Tong, Shuping, Nassal, Michael, Wen, YuMei, Wang, YongXiang. A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-32423-9.
Xiaotong Diao, Fei Ye, Meina Zhang, Xintong Ren, Xiaoxu Tian, Jingping Lu, Xiangnan Sun, Zeng Hou, Xiaoyu Chen, Fengwei Li, Jingjing Zhuang, Hong Ding, Chao Peng, Fraydoon Rastinejad, Cheng Luo, Dalei Wu. Identification of oleoylethanolamide as an endogenous ligand for HIF-3α. NATURE COMMUNICATIONS[J]. 2022, 13(1): 1-12, https://doaj.org/article/3f12a7f39e5c4af89eb48bcbee994f58.
Fan, Shijie, Yue, Liyan, Wan, Wei, Zhang, Yuanyuan, Zhang, Bidong, Otomo, Chinatsu, Li, Quanfu, Lin, Tingting, Hu, Junchi, Xu, Pan, Zhu, Mingrui, Tao, Hongru, Chen, Zhifeng, Li, Lianchun, Ding, Hong, Yao, Zhiyi, Lu, Junyan, Wen, Yi, Zhang, Naixia, Tan, Minjia, Chen, Kaixian, Xie, Yuli, Otomo, Takanori, Zhou, Bing, Jiang, Hualiang, Dang, Yongjun, Luo, Cheng. Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(50): 26105-26114, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000714779000001.
Xiong, Fengmin, Ding, Xiaoyu, Zhang, Hao, Luo, Xiaomin, Chen, Kaixian, Jiang, Hualiang, Luo, Cheng, Xu, Heng. Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2021, 41: http://dx.doi.org/10.1016/j.bmcl.2021.127986.
Gao, Feng, Chen, Xiaoxu, Lu, Junyan, Hu, Shulei, Xu, Hui, Shi, Yuqiang, Feng, Mingshun, Ding, Jian, Liu, Hong, Luo, Cheng, Xie, Zuoquan, Wang, Jiang. Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 215: http://dx.doi.org/10.1016/j.ejmech.2021.113274.
Zhang, Youyi, Ye, Fei, Zhang, Tongtong, Lv, Shiyun, Zhou, Liping, Du, Daohai, Lin, He, Guo, Fei, Luo, Cheng, Zhu, Shujia. Structural basis of ketamine action on human NMDA receptors. NATURE[J]. 2021, 596(7871): 301-+, http://dx.doi.org/10.1038/s41586-021-03769-9.
Zhang, Huimin, He, Jixiao, Hu, Guang, Zhu, Fei, Jiang, Hao, Gao, Jing, Zhou, Hu, Lin, Hua, Wang, Yingjuan, Chen, Kaixian, Meng, Fanwang, Hao, Minghong, Zhao, Kehao, Luo, Cheng, Liang, Zhongjie. Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(20): 15111-15125, http://dx.doi.org/10.1021/acs.jmedchem.1c01076.
Song, Bin, Chen, Yun, Liu, Xin, Yuan, Fei, Tan, Eddie Yong Jun, Lei, Yixuan, Song, Ning, Han, Yinqi, Pascal, Bruce D, Griffin, Patrick R, Luo, Cheng, Wu, Bin, Luo, Dahai, Zheng, Jie. Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. IMMUNITY[J]. 2021, 54(10): 2218-+, http://dx.doi.org/10.1016/j.immuni.2021.09.008.
Ding, Hong, Pei, Yuan, Li, Yuanqing, Xu, Wen, Mei, Lianghe, Hou, Zeng, Guang, Yiman, Cao, Liyuan, Li, Peizhuo, Cao, Haijing, Bian, Jinlei, Chen, Kaixian, Luo, Cheng, Zhou, Bing, Zhang, Ting, Li, Zhiyu, Yang, Yaxi. Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2021, 52: http://dx.doi.org/10.1016/j.bmc.2021.116512.
Lin, Tingting, Li, Jiacheng, Liu, Liping, Li, Yuanqing, Jiang, Hualiang, Chen, Kaixian, Xu, Pan, Luo, Cheng, Zhou, Bing. Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 215: http://dx.doi.org/10.1016/j.ejmech.2021.113281.
Zhou, Xiaoru, Li, Xiao, Liao, Liping, Han, Jie, Huang, Jing, Li, Jiacheng, Tao, Hongru, Fan, Shijie, Chen, Zhifeng, Li, Qi, Chen, Shijie, Ding, Hong, Yang, Yaxi, Zhou, Bing, Jiang, Hualiang, Chen, Kaixian, Zhang, Yuanyuan, Huang, Chuanxin, Luo, Cheng. P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K delta inhibitor idelalisib. ACTA PHARMACOLOGICA SINICA[J]. 2021, https://www.webofscience.com/wos/woscc/full-record/WOS:000639768200001.
Lu, Tian, Li, Yong, Lu, Wenchao, Spitters, Twgm, Fang, Xueyu, Wang, Jun, Cai, Simian, Gao, Jing, Zhou, Yanting, Duan, Zhe, Xiong, Huan, Liu, Liping, Li, Qi, Jiang, Hualiang, Chen, Kaixian, Zhou, Hu, Lin, Hua, Feng, Huijin, Zhou, Bing, Antos, Christopher L, Luo, Cheng. Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3. ACTA PHARMACEUTICA SINICA B[J]. 2021, 11(10): 3206-3219, http://dx.doi.org/10.1016/j.apsb.2021.04.015.
Kong, Qidi, Pan, Wei, Xu, Heng, Xue, Yaru, Guo, Bin, Meng, Xin, Luo, Cheng, Wang, Ting, Zhang, Shuhua, Yang, Yushe. Design, Synthesis, and Biological Evaluation of Novel Pyrimido4,5-bindole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(12): 8644-8665, http://dx.doi.org/10.1021/acs.jmedchem.1c00621.
Li, Wen, Liao, Liping, Song, Ning, Liu, Yanjun, Ding, Yiluan, Zhang, Yuanyuan, Zhou, Xiaoru, Sun, Zhongya, Xiao, Senhao, Wang, Hongbo, Lu, Jing, Zhang, Naixia, Jiang, Hualiang, Chen, Kaixian, Liu, Chuanpeng, Zheng, Jie, Zhao, Kehao, Luo, Cheng. Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase. ACTA PHARMACOLOGICA SINICA[J]. 2021, https://www.webofscience.com/wos/woscc/full-record/WOS:000639768200002.
Du, Daohai, Xu, Dandan, Zhu, Licheng, Stazi, Giulia, Zwergel, Clemens, Liu, Yanli, Luo, Zhongyuan, Li, Yuanqing, Zhang, Yuanyuan, Zhu, Kongkai, Ding, Yiluan, Liu, Jingqiu, Fan, Shijie, Zhao, Kaiyan, Zhang, Naixia, Kong, Xiangqian, Jiang, Hualiang, Chen, Kaixian, Zhao, Kehao, Valente, Sergio, Min, Jinrong, Duan, Wenhu, Luo, Cheng. Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(12): 8194-8207, http://dx.doi.org/10.1021/acs.jmedchem.0c02261.
Wang, Zhen, Zhang, Hao, Chen, Baoen, Ouyang, Sisheng, Zheng, Tong, Zhou, Ran, Dong, Ze, Huang, Yue, Zhang, Tao, Jiang, Hualiang, Gan, Jianhua, Luo, Cheng, Yang, CaiGuang. A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP-Protein Interactions in Kidney Cancer Cells. CHINESE JOURNAL OF CHEMISTRY[J]. 2021, 39(2): 274-280, http://dx.doi.org/10.1002/cjoc.202000462.
Ding, Xiaoyu, Zhao, Zijie, Wu, Yue, Zhang, Hao, Chen, Kaixian, Luo, Cheng, Luo, Xiaomin, Xu, Heng. Identification of novel anti-inflammatory Nur77 modulators by virtual screening. BIOORGANIC CHEMISTRY[J]. 2021, 112: http://dx.doi.org/10.1016/j.bioorg.2021.104912.
Huang, HeMing, Zhou, XiaoRu, Liu, YanJun, Fan, ShiJie, Liao, LiPing, Huang, Jing, Shi, CuiCui, Yu, Liang, Pen, JinJin, Luo, Cheng, Zhang, YuanYuan, Li, GuangMing. Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation. MOLECULAR MEDICINE REPORTS[J]. 2021, 23(5): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974418/.
Luo, Zhongyuan, Du, Daohai, Liu, Yanjun, Lu, Tian, Liu, Liping, Jiang, Hualiang, Chen, Kaixian, Shan, Changliang, Luo, Cheng. Discovery and characterization of a novel glucose-6-phosphate dehydrogenase (G6PD) inhibitor via high-throughput screening. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2021, 40: http://dx.doi.org/10.1016/j.bmcl.2021.127905.
Dong, Ze, Wang, Zhen, Guo, ZhongQiang, Gong, Shouzhe, Zhang, Tao, Liu, Jiang, Luo, Cheng, Jiang, Hualiang, Yang, CaiGuang. Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(9): 4849-4866, https://www.webofscience.com/wos/woscc/full-record/WOS:000535279800029.
Zuo, Yu, Xu, Heng, Chen, Zhifeng, Xiong, Fengmin, Zhang, Bei, Chen, Kaixian, Jiang, Hualiang, Luo, Cheng, Zhang, Hao. 17-AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA-MB-231 breast cancer cells. ONCOLOGY REPORTS[J]. 2020, 43(6): 1928-1944,
Hou, Zeng, Min, Wenjian, Zhang, Rukang, Niu, Ao, Li, Yuanqing, Cao, Liyuan, Han, Jie, Luo, Cheng, Yang, Peng, Ding, Hong. Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2020, 30(9): http://dx.doi.org/10.1016/j.bmcl.2020.127061.
Li, Zizhou, Xiao, Senhao, Yang, Yaxi, Chen, Chao, Lu, Tian, Chen, Zhifeng, Jiang, Hualiang, Chen, Shijie, Luo, Cheng, Zhou, Bing. Discovery of 8-Methyl-pyrrolo1,2-apyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(8): 3956-3975,
Lu, Tian, Lu, Wenchao, Luo, Cheng. A patent review of BRD4 inhibitors (2013-2019). EXPERT OPINION ON THERAPEUTIC PATENTS[J]. 2020, 30(1): 57-81, https://www.webofscience.com/wos/woscc/full-record/WOS:000502444100001.
Sun, Zhongya, Zhang, Hao, Zhang, Yuanyuan, Liao, Liping, Zhou, Wen, Zhang, Fengcai, Lian, Fulin, Huang, Jing, Xu, Pan, Zhang, Rukang, Lu, Wenchao, Zhu, Mingrui, Tao, Hongru, Yang, Feng, Ding, Hong, Chen, Shijie, Yue, Liyan, Zhou, Bing, Zhang, Naixia, Tan, Minjia, Jiang, Hualiang, Chen, Kaixian, Liu, Bo, Liu, Chuanpeng, Dang, Yongjun, Luo, Cheng. Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion. ADVANCED SCIENCE[J]. 2020, 7(14): https://doaj.org/article/2e4dbc3d2ae14c49977b0ef0da5f68ca.
Li, Zhiqiang, Li, Xinzhi, Su, MingBo, Gao, LiXin, Zhou, YuBo, Yuan, Bingchuan, Lyu, Xilin, Yan, Ziqin, Hu, Chujiao, Zhang, Hao, Luo, Cheng, Chen, Zheng, Li, Jia, Zhao, Yujun. Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(8): 4388-4407, https://www.webofscience.com/wos/woscc/full-record/WOS:000529170200035.
Min, Wenjian, Hou, Zeng, Zhang, Fang, Xie, Shengnan, Yuan, Kai, Dong, Haojie, Wang, Liping, Qi, Lianwen, Luo, Cheng, Ding, Hong, Yang, Peng. Computational discovery and biological evaluation of novel inhibitors targeting histone-lysine N-methyltransferase SET7. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2020, 28(7): http://dx.doi.org/10.1016/j.bmc.2020.115372.
Hait, Nitai C, Maiti, Aparna, Xu, Pan, Qi, Qianya, Kawaguchi, Tsutomu, Okano, Maiko, Takabe, Kazuaki, Yan, Li, Luo, Cheng. Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate. FASEB JOURNAL[J]. 2020, 34(3): 4293-4310, https://www.webofscience.com/wos/woscc/full-record/WOS:000511114000001.
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