杨　冬 - 北京师范大学 - 生命科学学院

个人简介

1.受教育经历 2006年：美国Texas A&M University， Department of Biochemistry and Biophysics, 博士 1998年：浙江大学，生物科学与技术系，学士 2.研究工作经历 2010-当前：北京师范大学，生命科学学院，副教授 2006-2010年：美国NIH（国立卫生研究院）博士后

研究领域

■转运必需内体分选复合物（ESCRT）是一类与细胞中的膜结构的重构有关的重要蛋白复合物。其在膜蛋白降解，信号传导，病毒出芽，细胞分裂，膜损伤修复等诸多重要过程中发挥作用。我们主要研究ESCRT系统在白色念珠菌中，对其极性生长，信号转导以及膜损伤修复的作用及机理，从而理解该复合物在致病真菌的致病性上所发挥的作用以及其分子机制。 ■萜类物质是目前具有最广泛多样性的天然产物。其通常可以由植物或者微生物合成，其不仅具有重要生理作用，同时在医药，食品，日化等行业有广泛应用。我们通过结合结构生物学技术，研究重要的萜烯合成酶的机理，从而理解萜类产物多样性的机制。同时，通过蛋白质工程和代谢工程技术，以研究在微生物中合成重要萜烯产物。

近期论文

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■Zhang, J., Zhao, R., Lin, S., Yang, D., Lu, S., Liu, Z., Gao, Y., Zhang, Y., Hou, B., Xi, C., Liu, J., Bing, J., Pang, E., Lin, K. and Zeng, S., Comparison of genes involved in brain development: insights into the organization and evolution of the telencephalic pallium. Sci. Rep., 14, 6102, 2024 ■Ren, Q., Guo, X., Yang, D., Zhao, C., Zhang, X. and Xia, X., A wide survey of heavy metal-induced in-vitro DNA replication stress characterized by rate-limited replication. Curr. Res. Toxicol., 6, 100152, 2024 ■Li, M., Yang, Z., Chen, S., Liu, Z., Tong, L., Zheng, S. and Yang, D., Sphaerotilus natans hemoglobins have an NADH oxidation activity and promote the yield of limonene in an engineered E. coli strain. Int. J. Biol. Macromol., 254 (Pt 3), 128112, 2024 ■Xu, J., Peng, G., Xu, J., Li, Y., Tong, L. and Yang, D., Probing of the plasticity of the active site in pinene synthase elucidates its potential evolutionary mechanism. Phytochemistry, 181, 112573, 2021 ■Yang, T., Li, W., Li, Y., Liu, X. and Yang, D.，The ESCRT System Plays an Important Role in the Germination in Candida albicans by Regulating the Expression of Hyphal-Specific Genes and the Localization of Polarity-Related Proteins. Mycopathologia, 185, 439-454‬, 2020 ■Xu, J., Xu, J., Ai, Y., Farid, R.A., Tong, L. and Yang, D., Mutational analysis and dynamics of S-limonene synthase reveal the importance of Y573: insight into the cyclization mechanism in monoterpene synthases. Arch Biochem Biophys, 638, 27-34, 2018 ■Xu, J., Ai, Y., Wang, J., Xu, J., Zhang, Y. and Yang, D., Converting S-limonene synthase to pinene and phellandrene synthases reveals the plasticity of the active site. Phytochemistry, 137, 34-41, 2017 ■Zhang, Y.，Li, W., Chu, M.，Chen, H.，Yu, H., Fang, C., Sun, N, Wang, Q., Luo, T., Luo, K., She, X., Zhang, M. and Yang, D., The AAA ATPase Vps4 plays important roles in Candida albicans hyphal formation and is inhibited by DBeQ. Mycopathologia, 181, 329-339‬, 2016 ■Qian, M-X., et al., Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis.Cell，153，1012-1024‬, 2013 ■Yang, D. and Hurley, J. H., Structural role of the Vps4-Vta1 interface in the ESCRT-III recycling. Structure，18，976-984‬, 2010 ■Yang, D., Rismanchi, N., Renvois, B., Lippincott-Schwartz, J., Blackstone, C. and Hurley, J. H.， Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat. Struct. Mol. Biol.，15， 1278-1286‬， 2008