个人简介

January 5th, 1976 Born in Hamburg 06/1995 Abitur (high-school diploma) 07/1995-04/1996 Mandatory military service 04/1996-03/1998 Studies in chemistry at Universität Hamburg 05/1998-09/2000 Advanced studies in chemistry at Ludwig-Maximilians- Universität München 03/2000-09/2000 Diploma thesis under the guidance of Prof. Herbert Mayr (physical organic chemistry) 11/2000-01/2004 Coworker of Prof. Helmut Schwarz at Technische Universität Berlin 11/2000-10/2003 Doctoral Thesis: Gaseous Platinum Clusters - Versatile Models for Heterogeneous Catalysts 03/2001-05/2001 Research visit with Prof. Peter B. Armentrout at the University of Utah, Salt Lake City 03/2001-02/2003 Kekulé fellowship of the Fonds der Chemischen Industrie 11/2004 Schering-Preis of the Schering-Stiftung, Berlin 01/2004-11/2006 Postdoctoral research with Prof. Richard N. Zare, Stanford University (topic: state-to-state dynamics of the hydrogen exchange reaction 09/2004-08/2006 Emmy Noether postdoctoral fellowship of the Deutsche Forschungsgemeinschaft) 12/2006-10/2011 Independent research at Ludwig-Maximilians-Universität München 12/2007 Römer-Preis of the Dr. Klaus Römer-Stiftung, München 12/2010 Support from the Dr. Otto Röhm Gedächtnisstiftung, Darmstadt 01/2012 Habilitation (Organic Chemistry) Since 11/2011 Associate Professor (W2) for Organic Chemistry, Georg- August-Universität Göttingen 03/2015 Mattauch-Herzog-Förderpreis of the Deutsche Gesellschaft für Massenspektrometrie

研究领域

Identification and characterization of organometallic reagents and intermediates. Proof of weakly bonded associates by electrospray ionisation mass spectrometry.

Motivation Our research aims at a detailed understanding of chemical processes at the molecular level. We believe that the thus gained mechanistic insight is not only of interest in its own right, but in the long term will provide the best way for reagent and catalyst optimization, the development of new synthetic methods, and the manipulation of biological systems. Methods Much of our work involves organic/organometallic synthesis to prepare samples of interest, which we then analyze by various analytical methods, such as NMR spectroscopy, UV/vis spectroscopy, and electrical conductivity measurements. As a particularly useful tool to probe ionic intermediates, we employ electrospray ionization (ESI) mass spectrometry. In doing so, we are also interested in achieving a better understanding of the ESI process. Moreover, we apply tandem-mass spectrometry to study the reactivity of mass-selected ionic intermediates in the gas phase. Thus, we can assess how single bound solvent molecules, different ligands, and different aggregation states affect the reactivity at the molecular level. Organometallics and Catalysis Current activities in the field of organometallics center on anionic ate complexes, such as organocuprates, -zincates, and -indates. The anionic character of these species enhances their nucleophilicity, thus making them synthetically valuable. We probe the aggregation and association equilibria of these reagents in solution and determine their reactivity by kinetic measurements in solution and in the gas phase. We are also interested in elucidating the mechanism of transition-metal mediated reactions, such as cross-coupling and C-H activation processes. For example, we have been able to observe and characterize a series of elusive Cu(III) intermediates. Non-Covalently Bound Complexes of Biomolecules Using ESI mass spectrometry, we probe DNA-stabilized silver nanoclusters and the association of biomolecules.

近期论文

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Catalyst Activation, Deactivation, and Degradation in Palladium-Mediated Negishi Cross-Coupling Reactions K. Böck, J. E. Feil, K. Karaghiosoff, K. Koszinowski, Chem. Eur. J. 2015, 21, 5548-5560. Triostin A Derived Cyclopeptide as Architectural Template for the Alignment of Four Recognition Units U. M. Kotyrba, K. Pröpper, E.-F. Sachs, A. Myanovska, T. Joppe, F. Lissy, G. M. Sheldrick, K. Koszinowski, U. Diederichsen, Chem. Open 2014, 3, 152-160. Structural and reactivity insights in Mg-Zn hybrid chemistry: Zn-I exchange and Pd-catalysed cross-coupling applications of aromatic substrates T. D. Bluemke, W. Clegg, P. García-Alvarez, A. R. Kennedy, K. Koszinowski, M. D. McCall, L. Russob, E. Hevia, Chem. Sci. 2014, 5, 3552-3562. Organozinc Pivalate Reagents: Segregation, Solubility, Stabilization, and Structural Insights A. Hernán-Gómez, E. Herd, E. Hevia, A. R. Kennedy, P. Knochel, K. Koszinowski, S. M. Manolikakes, R. E. Mulvey, C. Schnegelsberg, Angew. Chem. 2014, 126, 2744-2748; Angew. Chem. Int. Ed. 2014, 53, 2706-2710. Counter-ion and solvent effects in electrospray ionization of solutions of alkali metal and quaternary ammonium salts K. Koszinowski, F. Lissy, Int. J. Mass Spectrom. 2013, 354/355, 219-228. Ionic Aggregates of Lithium Organocuprates A. Putau, M. Wilken, K. Koszinowski, Chem. Eur. J. 2013, 19, 10992-10999. β-Hydrogen Elimination of Ionic Butylzinc Complexes K. Koszinowski, C. Müller, H. Brand, J. E. Fleckenstein, Organometallics 2012, 31, 7165-7170. InCl3-katalysierte Synthese von 1,2-dimetallierten Verbindungen durch direkte Insertion von Aluminium- oder Zinkpulver InCl3-Catalyzed Synthesis of 1,2-Dimetallic Compounds by Direct Insertion of Aluminum or Zinc Powder T. D. Blümke. T. Klatt, K. Koszinowski, P. Knochel, Angew. Chem. 2012, 124, 10064-10068; Angew. Chem. Int. Ed. 2012, 51, 9926-9930. Tetraalkylcuprates(III): Formation, Association, and Intrinsic Reactivity A. Putau, H. Brand, K. Koszinowski, J. Am. Chem. Soc. 2012, 134, 613-622. Lithium Organozincates LiRZnX2: Common Species in Organozinc Chemistry J. E. Fleckenstein, K. Koszinowski, Organometallics 2011, 30, 5018-5026. Association and Dissociation of Lithium Cyanocuprates in Ethereal Solvents A. Putau, K. Koszinowski, Organometallics 2011, 30, 4771-4778. Charged Tags as Probes for Analyzing Organometallic Intermediates and Monitoring Cross-Coupling Reactions by Electrospray-Ionization Mass Spectrometry M. A. Schade, J. E. Fleckenstein, P. Knochel, K. Koszinowski, J. Org. Chem. 2010, 75, 6848-6857. Probing Cyanocuprates by Electrospray Ionization Mass Spectrometry A. Putau, K. Koszinowski, Organometallics 2010, 29, 3593-3601. Addition/Correction: Organometallics 2010, 29, 6841-6842. Oxidation State, Aggregation, and Heterolytic Dissociation of Allyl Indium Reagents K. Koszinowski, J. Am. Chem. Soc. 2010, 132, 6032-6040. A Highly Charged Ag64+ Core in a DNA-Encapsulated Silver Nanocluster K. Koszinowski, K. Ballweg, Chem. Eur. J. 2010, 16, 3285-3290. Microsolvated and Chelated Butylzinc Cations: Formation, Relative Stability, and Unimolecular Gas-Phase Reactivity J. E. Fleckenstein, K. Koszinowski, Chem. Eur. J. 2009, 15, 12745-12753. Formation of Organozincate Anions in LiCl-Mediated Zinc Insertion Reactions K. Koszinowski, P. Böhrer, Organometallics 2009, 28, 771-779. Aggregation and Reactivity of Organozincate Anions Probed by Electrospray Mass Spectrometry K. Koszinowski, P. Böhrer, Organometallics 2009, 28, 100-110. Vibrationally inelastic H + D2 collisions are forward-scatterd N. T. Goldberg, J. Zhang, K. Koszinowski, F. Bouakline, S. C. Althorpe, R. N. Zare, Proc. Natl. Acad. Sci. USA 2008, 105, 18194-18199. Differential cross section for the H+D2 → HD (ν' = 1, j' = 2,6,10)+D reaction as a function of collision energy K. Koszinowski, N. T. Goldberg, J. Zhang, R. N. Zare, F. Bouakline, S. C. Althorpe, J. Chem. Phys. 2007, 127, 124315-1-10. The unexpected gas-phase reactivity of the CH3OH adduct of Michler?s hydrol blue: Proton-shuttle catalysis and stepwise radical expulsions D. Schröder, J. Roithová, P. Gruene, H. Schwarz, H. Mayr, K. Koszinowski, J. Phys. Chem. A 2007, 111, 8925-8933.