个人简介
严继舟，水产与生命学院生物学系教授。九三学社社员。
1980年至1988年就读武汉大学医学部医学系和病原生物学专业，先后获医学学士和硕士学位。1993年至1995年获中英科技合作项目资助在英国伦敦大学伦敦卫生和热带医学学院（London School of Hygiene and Tropical Medicine）进修血清流行病学和分子生物学。1996年-1999年攻读第二军医大学病原生物学博士获医学博士学位。2000年6月-2005年3月美国国立卫生研究院主要研究转基因技术和斑马鱼发育基因组学。2005年3月应聘美国宾夕法尼亚大学医学院 (University of Pennsylvania School of Medicine )，从事小鼠胚胎干细胞的培养和造血干细胞定向分化以及抑癌基因表观遗传学和信号转导研究。2009年3月回国就职于上海海洋大学水产与生命学院、上海海洋大学海洋科学研究院海洋生物系统和神经科学研究所。
教学工作
[1] 本科教学：主讲《生物化学》,《生物化学实验》和《营养与疾病》。
[2] 研究生教学：主讲《生物工程原理与技术》和《组织细胞培养理论与技术》
授权专利
严继舟，杜新路，郭会萍，王成辉。一种改良注射混合液制备及使用方法。ZL 2019 1 0133030.2. 发明专利。
代表性专著和教材
[1] Gene Regulatory Networks : Methods and Protocols (Editors: Bart Deplancke, Nele Gheldof). Jizhou Yan, Shawn Burgess. Using a yeast inverse one-hybrid system to identify functional binding sites of transcription factors. Methods Mol Biol. 2012;786:275-290
[2] 李志勇主编《细胞工程实验》（1）吕恺伦、严继舟*. 第三篇细胞工程综合实验-第六章动植物人工繁殖-实验二十鱼类**冻存与体外受精；(2）高思琪、严继舟* 第四篇前沿探索实验-实验四十三 用斑马鱼受精卵建立人类疾病模型。高教出版社，2016
[3]《健康与疾病的营养基因组学研究》，严继舟、王晓杰编著，学苑出版社，2018年，北京。
研究领域
淡水和海水生物在营养和生物医学研究的开发应用：水生生物组织再生和细胞可塑性的生理生化特征。目前研究课题：
[1] 海星和大闸蟹特色生物活性物质的营养基因组学研究;
[2] 斑马鱼心脏和下颌组织完全再生的细胞转分化及结构重建的细胞可塑性再生机制；
[3] 引导性腺细胞转分化和再生的sox9-信号通路调节。
近期论文
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[1] Xuelong Wang,Huiping Guo, Feifei Yu, Hui Zhang, Ying Peng, Chenghui Wang, Gang Wei, Jizhou Yan. Keratin 5-cytoskeleton-BMP network regulates cell phenotype conversions during cardiac regeneration. Experimental Cell Research 2022, 418:113272
[2] Xuelong Wang, Jizhou Yan, Zhao Ye, Zhiqiang Zhang,Sheng Wang, Shuang Hao, Baiyong Shen andGang Wei.Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells. Frontiers in Cell and Developmental Biology 2022, 10:974750
[3] Xuelong Wang, Jizhou Yan, Baiyong Shen and Gang Wei. Integrated Chromatin Accessibility and Transcriptome Landscapes of Doxorubicin-Resistant Breast Cancer Cells. Frontiers in Cell and Developmental Biology 2021, 9:708066
[4] Huiping Guo, Xinlu Du, Ying Zhang, Jiacheng Wu, Chenghui Wang, Mingyou Li, Xianxin Hua, Xin A. Zhang, Jizhou Yan*. Specific miRNA-G Protein-Coupled Receptor Networks Regulate Sox9a/Sox9b Activities to Promote Gonadal Rejuvenation in Zebrafish. Stem Cells 2019;37:1189–1199
[5 YaLan Wei, Ling Huang, Jinghui Cao, Chenghui Wang and Jizhou Yan. Dietary safety Assessment of lk1-Transgenic Fish. Frontiers in Physiology 2018 ； 9 | Article 8.
[6] Hui Zhang, Wen Wen, Jizhou Yan. Application of immunohistochemistry technique in hydrobiological studies. Aquaculture and Fisheries 2 (2017) 140e144
[7] Yancen Dai, Nagarajan Prithiviraj, Jianhong Gan, Xin A. Zhang，Jizhou Yan．Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regenerationof Zebrafish．Scientific Reports 2016, 6, 38693
[8] Xin He, Lei Wang, Jizhou Yan, Chaoxing Yuan, Eric S. Witze, and Xianxin Hua. Menin localization in cell membrane compartment. Cancer Biology & Therapy 2016;17 (1): 114-122.
[9] Jin Feng, Chao Huang, Jonathan D. Wren, Dao-Wen Wang, Jizhou Yan, Jiexin Zhang, Yujie Sun, Xiao Han, Xin A. Zhang. Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity. Cancer Metastasis Rev 2015; 34:619–633.
[10] Hui Zhang, Xuelong Wang, Kailun Lyu, Siqi Gao, Guan Wang , Chunxin Fan, Xin A. Zhang Jizhou Yan. Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw. Stem Cells 2015;33：806-8181
[11] Dongjie Sun, Ying Zhang, Chen Wang, Xianxin Hua, Xin A. Zhang, Jizhou Yan. Sox9-related signaling controls zebrafish juvenile ovary-testis transformation. Cell Death & Diseases 2013; 4, e930
[12] Xuelong Wang, Huihui He, Wenqiao Tang, Xin A. Zhang, Xianxin Hua, Jizhou Yan Two origins of blastemal progenitors define blastemal regeneration of zebrafish lower jaw. PloS One 2012;7（9）:e45380
[13] Huihui He, Xianxin Hua, Jizhou Yan. Epigenetic regulations in hematopoietic Hox code. Oncogene 2011;30:379-388
[14] Austin T. Thiel, Peter Blessington, Tao Zou, Danielle Feather, Xinjiang Wu, Jizhou Yan, Hui Zhang, Zuguo Liu, Patricia Ernst, Gary A. Koretzky, and Xianxin Hua. MLL-AF9-induced leukemogenesis requires co-expression of the wild type Mll allele. Cancer Cell 2010;17(2):148- 59
[15] Jizhou Yan, Yuqing Yang, Hui Zhang, Catrina King, H-M Kan, C-X Yuan, GS Bloom and X Hua. Menin interacts with IQGAP1 to enhance intercellular adhesion of beta cells. Oncogene 2009;28 (7):973.
[16] Jizhou. Yan, Xiang Yang, Mark A. Martin, Mohammed Shahabuddin. Malaria sporozoite antigen-directed genome-wide responses in transgenic Drosophila. Genesis 2009; 47（3）：196.
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