Education & Positions
Professor of Chemistry, The University of Chicago, 2016-
Assistant Professor, CPRIT Scholar for Cancer Research, University of Texas at Austin, 2011 – 2016
Camille and Henry Dreyfus Postdoctoral Fellow, California Institute of Technology, 2009 – 2011
Ph.D. in Chemistry, Stanford University, Stanford, California, 2004 – 2009
B.S. in Chemistry, Peking University, Beijing, China, 1999 – 2003
Arthur C. Cope Scholar Award 2017
American Cancer Society Research Scholar 2014
Amgen Young Investigators’ Award 2014
Dupont Young Professor Program Award 2014
Teaching Excellent Award, UT Austin 2014
CAPA Biomatik Distinguished Junior Faculty Award 2014
Sloan Research Fellow 2014
Searle Scholar Award 2013
National Science Foundation CAREER Award 2013
Thieme Synlett/Synthesis Journal Award 2012
1) C–C Bond Activation. Our long-term goal is to greatly extend the regime of C−C activation to a wide range of organic compounds and enable synthetically useful transformations.
2) Byproduct-Free Ketone Alkylation.
3) Non-Directed β-Functionalization of Carbonyl Compounds.
4) Exo-type Directing Group for Site-selective C−H Activation.
5) Palladium/Norbornene Catalysis.
6) Total Synthesis and Drug Discovery.
7) Polymer Chemistry.
Zhou, Xukai; Xu, Yan* and Dong, Guangbin* “Olefination via Cu-Mediated Dehydroacylation of Unstrained Ketones” J. Am. Chem. Soc. 2021, in press.
Xie, Jiaxin; Liu, Xin; Zhang, Nan; Choi, Shinyoung and Dong, Guangbin* “Bidirectional Total Synthesis of Phainanoid A via Strategic Use of Ketones” J. Am. Chem. Soc. 2021, 143, 19311-19316.
Wu, Zhao; Xu, Xiaolong; Wang, Jianchun and Dong, Guangbin* “Carbonyl 1,2-transposition through triflate-mediated α-amination” Science 2021, 374, 734-740.
Ashfeld, Brandon L.; Judd, Andrew S.; Xie, Jiaxin and Dong, Guangbin “Chloro(1,5-Cyclooctadiene)Rhodium(I) Dimer” Encyclopedia of Reagents for Organic Synthesis; John Wiley & Sons, Ltd: Hoboken, NJ, 2021.
Li, Renhe and Dong, Guangbin* “Redox-Neutral Vicinal Difunctionalization of Five-Membered Heteroarenes with Dual Electrophiles” Angew. Chem., Int. Ed. 2021, 60, 26184-26191.
Xie, Qiqiang and Dong, Guangbin* “Aza-Matteson Reactions via Controlled Mono- and Double-Methylene Insertions into Nitrogen–Boron Bonds” J. Am. Chem. Soc. 2021, 143, 14422-14427.
Zhou, Xukai.; Xu, Yan* and Dong, Guangbin* “Deacylation-aided C–H alkylative annulation through C–C cleavage of unstrained ketones” Nat. Catal. 2021, 4, 703-710.
Zhu, Jun‡.; Zhang, Rui‡ and Dong, Guangbin* “Orthogonal cross-coupling through intermolecular metathesis of unstrained C(aryl)–C(aryl) single bonds” Nat. Chem. 2021, 13, 836-842.
Zhou, Bo.; Qi, Xiaotian.;* Liu, Peng.* and Dong, Guangbin* “Development and Mechanistic Studies of the Iridium-catalyzed C−H Alkenylation of Enamides with Vinyl Acetates: A Versatile Approach for Ketone Functionalization” Angew. Chem., Int. Ed. 2021, 60, 20926-20934.
Zhang, Rui; Xia, Ying and Dong, Guangbin* “Intermolecular [5+2] Annulation between 1-Indanones and Internal Alkynes by Rh-catalyzed C−C Activation” Angew. Chem., Int. Ed. 2021, 60, 20476-20482.
Liu, Xin; Wang, Jianchun* and Dong, Guangbin* “Modular Entry to Functionalized Tetrahydrobenzo[b]azepines via the Palladium/Norbornene Cooperative Catalysis Enabled by a C7-Modified Norbornene” J. Am. Chem. Soc. 2021, 143, 9991–10004. [doi]
Xue, Yibin and Dong, Guangbin* “Total Synthesis of Penicibilaenes via C–C Activation-Enabled Skeleton Deconstruction and Desaturation Relay-Mediated C–H Functionalization” J. Am. Chem. Soc. 2021, ASAP.
Wu, Zhao; Fatuzzo, Nina and Dong, Guangbin* “Palladium/Norbornene-Catalyzed Distal Alkenyl C–H Arylation and Alkylation of cis-Olefins” Tetrahedron 2021, in press.
Tsogoeva, Svetlana B.* Dong, Guangbin* and Ackermann, Lutz* “Editorial: The Catalysis of Ring Synthesis” ChemCatChem 2021, 13, 1–4.
Rago, Alexander J. and Dong, Guangbin* “Synthesis of C3,C4-Disubstituted Indoles via the Palladium/Norbornene-Catalyzed ortho-Amination/ipso-Heck Cyclization” Org. Lett. 2021, in press.
Hairong Lyu; Kevlishvili, Ilia; Yu, Xuan; Liu, Peng* and Dong, Guangbin* “Boron insertion into alkyl ether bonds via zinc/nickel tandem catalysis” Science 2021, 372, 175-182.
Zhang, Rui and Dong, Guangbin* “Transfer hydroarylation of ketones using directing-group-free, unstrained alcohols” Chem 2021, 7, 841-842.
“Deconstructive Asymmetric Total Synthesis of Morphine‐Family Alkaloid (‐)‐Thebainone A” Hou, Si-Hua; Prichina, Adriana Y. and Dong, Guangbin* Angew. Chem. Int. Ed. 2021, In press.
Rago, Alexander J. and Dong, Guangbin* “Synthesis of indoles, indolines, and carbazoles via palladium-catalyzed C–H activation” Green Synth. Catal. 2021, in press.
Chen, Ming and Dong, Guangbin* “Platinum‐catalyzed α,β‐Desaturation of Cyclic Ketones through Direct Metal‐enolate Formation” Angew. Chem. Int. Ed. 2021, 60, 7956-7961.